How does the immune system keep tabs on the brain?

Alzheimer’s disease, multiple sclerosis, autism, schizophrenia and many other neurological and psychiatric conditions have been linked to inflammation in the brain. There’s growing evidence that immune cells and molecules play a key role in normal brain development and function as well. But at the core of the burgeoning field of neuroimmunology lies a mystery: How […]

For some, GI tract may be vulnerable to COVID-19 infection

No evidence so far indicates that food or drinks can transmit the virus that causes COVID-19, but new research at Washington University School of Medicine in St. Louis suggests that people with problems in the upper gastrointestinal (GI) tract may be vulnerable to infection after swallowing the virus.

Bateman, Diamond, Hultgren named to National Academy of Inventors

Neurologist Randall J. Bateman, MD, virologist and immunologist Michael S. Diamond, MD, PhD, and microbiologist Scott Hultgren, PhD – all faculty members at Washington University School of Medicine in St. Louis – have been named fellows of the National Academy of Inventors, the highest professional distinction accorded solely to academic inventors.

Faculty Member Featured in College of American Pathologists

Melanie Yarbrough, PhD, was recently featured in CAP Today. The article focuses on Dr. Yarbrough’s work implementing a urine reflex algorithm to help increase the odds for success in reducing the number of urine cultures.  

Lethal brain infections in mice thwarted by decoy molecule

Researchers at Washington University School of Medicine in St. Louis have identified a molecule that protects mice from brain infections caused by Venezuelan equine encephalitis virus (VEEV), a mosquito-borne virus notorious for causing fast-spreading, deadly outbreaks in Mexico, Central America and northern South America. As the climate changes, the virus is likely to expand its […]

Study: Respiratory failure in COVID-19 usually not driven by cytokine storm

The turning point for people with COVID-19 typically comes in the second week of symptoms. As most people begin to recover, a few others find it increasingly difficult to breathe and wind up in the hospital. It has been theorized that those whose lungs begin to fail are victims of their own overactive immune systems.

Duncavage and Heusel to Lead Two New Department Sections

In an effort to enhance clinical genomic services at Washington University School of Medicine, the Department of Pathology & Immunology is pleased to announce the formation of two new sections; Clinical Cancer Genomics and Constitutional Genomics. Eric Duncavage, MD will serve as the inaugural head of Clinical Cancer Genomics and Jonathon Heusel, MD, PhD will […]

Role of gut viruses in inflammatory bowel disease is focus of $8.5 million grant

The communities of bacteria that live in our digestive tracts help digest food and produce vitamins, protect against pathogens, and promote the healthy functioning of our immune system. But alongside gut bacteria thrives a vast community of viruses, and we know little about their impact on health and disease.

New discovery could help improve cancer vaccines

Cancer vaccines have shown promise in treating certain tumors, such as melanoma. But such vaccines have limitations. They often target normal proteins that may be more abundant in the tumor but also are present in healthy tissue, which can lead to off-target effects that cause autoimmune disorders and also reduce the effectiveness of the vaccines

Brian Edelson, MD, PhD Recognized for Contributions in Education

Brian Edelson, MD, PhD was recently inducted into the Washington University School of Medicine Academy of Educators. The ceremony was held on September 24 to coincide with Education Day sponsored by the School of Medicine. Edelson was acknowledged for his important and varied contributions to our ongoing educational programs, and roles in building the new Gateway Curriculum.  To be selected […]

Antibodies protect against wide range of influenza B virus strains

Researchers have identified two antibodies that protect mice against lethal infections of influenza B virus, report scientists at Washington University School of Medicine in St. Louis and Icahn School of Medicine at Mount Sinai. Together with an antibody that targets the other major kind of influenza viruses that infect people — influenza A — these […]

Immune system affects mind and body, study indicates

New research at Washington University School of Medicine in St. Louis helps illuminate a surprising mind-body connection. In mice, the researchers found that immune cells surrounding the brain produce a molecule that is then absorbed by neurons in the brain, where it appears to be necessary for normal behavior.

Study provides insight on how to build a better flu vaccine

Flu season comes around like clockwork every year, and sooner or later everyone gets infected. The annual flu shot is a key part of public health efforts to control the flu, but the vaccine’s effectiveness is notoriously poor, falling somewhere from 40% to 60% in a typical year.

Washington University develops COVID-19 saliva test

A new saliva test to detect the SARS-CoV-2 virus has been developed by researchers at Washington University School of Medicine in St. Louis. Results from the COVID-19 diagnostic test are available in a few hours and, ideally, able to be communicated to people tested within a day. Highly sensitive to detecting even tiny levels of […]

Nasal vaccine against COVID-19 prevents infection in mice

Scientists at Washington University School of Medicine in St. Louis have developed a vaccine that targets the SARS-CoV-2 virus, can be given in one dose via the nose and is effective in preventing infection in mice susceptible to the novel coronavirus. The investigators next plan to test the vaccine in nonhuman primates and humans to […]

New center to explore brain, immune system connections

As the brain reigns supreme over the human body, the immune system works 24/7 to defend the body from foreign invaders. For decades, however, the brain and the immune system were thought to operate independently of one another. But a growing body of evidence suggests the two are intimately connected in keeping the body healthy.

Immunotherapy-resistant cancers eliminated in mouse study

Immunotherapy has revolutionized cancer treatment by stimulating the patient’s own immune system to attack cancer cells, yielding remarkably quick and complete remission in some cases. But such drugs work for less than a quarter of patients because tumors are notoriously adept at evading immune assault.

ASCP’s 40 Under Forty List Includes P&I Faculty Member

The American Society for Clinical Pathology has named Suzie Thibodeaux as one of 40 high-achieving pathologists, pathology residents, and medical laboratory professionals under age 40. She joins many other pathology professionals on the prestigious 2020 ASCP 40 Under Forty list. “Being recognized by the ASCP in their 40 under forty list is an amazing honor. […]

Jeff Gordon Featured on 60 Minutes

On Sunday, 60 Minutes featured our own Jeff Gordon, who discussed the gut microbiome and its connection to nutritional health, including the use of probiotics. The possibility of improving health by manipulating the microbiome could provide many benefits to individuals suffering from a host of health conditions. Last year, Gordon’s team reported that a special […]

COVID-19 antibody tests evaluated as diagnostic test in low-resource settings

With Brazil leading the world in newly diagnosed COVID-19 cases, Latin America has become the epicenter of the coronavirus pandemic. Meanwhile, outbreaks continue to escalate in parts of Asia, Africa and the Middle East. Public health authorities worldwide desperately need to expand testing so they can track the spread of the infection, but molecular diagnostic […]

COVID-19 mouse model will speed search for drugs, vaccines

The global effort to quickly develop drugs and vaccines for COVID-19 has been hampered by limited numbers of laboratory mice that are susceptible to infection with SARS-CoV-2, the virus that causes COVID-19. Now, researchers at Washington University School of Medicine in St. Louis report they have developed a mouse model of COVID-19 that replicates the […]

Abstract Receives Award from Society for Pediatric Pathology

An abstract co-authored and entitled, “PD-L1/PD-1 Expression in Wilms Tumor: Analysis of 52 cases” has won the Gordon F. Vawter Pathologist-in-Training Award at the Society for Pediatric Pathology 2020 at its Spring Meeting in Los Angeles, CA. The award recognizes meritorious work presented by Jeff Chen, MD based on research conducted by a group of […]

Experts urge caution in interpreting COVID-19 antibody tests

As stay-at-home orders are lifted around the country and public life begins to return, health experts continue to emphasize the importance of testing for COVID-19 to prevent a second – and potentially worse – wave of infections.

Pathology Faculty Member Selected as Loeb Teaching Fellow

Ian Hagemann, MD, PhD has been selected as the Carol B. and Jerome T. Loeb Teaching Fellow for the term July 1, 2020 through June 30, 2022. “Ian’s contributions to education in pathology and to the medical school are truly outstanding. Among his accomplishments are numerous Distinguished Service Teaching Awards, selection as a chair for […]

Trainee Research Award Day 2020

On Tuesday, the culmination of weeks of work for this year’s Trainee Research Day was put on full display via Zoom. Although different than past events, this year still had the air of excitement as trainees presented their research. This year, the department had 24 individuals present. As per the tradition, the Trainee Research Day […]

LGM Faculty Member Receives Award from ASM

On May 4, the 2020 American Academy of Microbiology announced awards for research, education, and leadership. Among those receiving awards was Carey-Ann Burnham, PhD, from the Division of Laboratory and Genomic Medicine. “For Dr. Burnham to receive the American Society for Microbiology (ASM) Award for Research and Leadership in Clinical Microbiology is a tremendous honor. This […]

Obesity prevented in mice treated with gene-disabling nanoparticles

Disabling a gene in specific mouse cells, researchers at Washington University School of Medicine in St. Louis have prevented mice from becoming obese, even after the animals had been fed a high-fat diet. The researchers blocked the activity of a gene in immune cells. Because these immune cells — called macrophages — are key inflammatory […]

A Letter to Laboratory professionals dedicated to fighting virus

Originially posted on stltoday. com. Click the button to be taken to the article. Until the cornonavirus outbreak, most people never gave much thought to laboratory testing. When your doctor says, “we’ll send it to the lab,” you rightly expect to get timely and accurate test results back. But this year’s pandemic spotlights that what […]

Office of Education Names Vice Chair

Dr. Erika Crouch recently accepted the position of Vice Chair of the Office of Education in the Department of Pathology and Immunology. Erika is one of the most celebrated and honored faculty in the entire school of medicine for her outstanding work in medical education. It is entirely fitting and appropriate that she be the […]

Clinical Chemistry Journal Highlights Mitch Scott, PhD

The American Academy for Clinical Chemistry has published it’s the most recent version of the Clinical Chemistry journal and it features a familiar face. The department’s own Mitchell Scott, PhD graces the cover, in addition, the series presents the achievements of distinguished clinical chemists. Scott joins an illustrious and short list of clinical pathologists to […]

Welcome New Trainees Starting July 2020

Pathology & Immunology is excited and proud to welcome the newest members of our department. These new residents and fellows will begin the next chapter of their medical education journey this July. To see a list of all the new trainees click here.

Brunt receives award from liver pathology society

Elizabeth M. Brunt, MD, a professor emeritus of pathology and immunology at Washington University School of Medicine in St. Louis, has received a Lifetime Achievement Award for Contributions to Liver Pathology from the Hans Popper Hepatopathology Society.

Gronowski given clinical chemistry award

Recognized for contributions to reproductive medicine diagnostics Ann M. Gronowski, PhD, a professor and vice-chair of faculty affairs and development in the Department of Pathology and Immunology at Washington University School of Medicine in St. Louis, has received the Academy Award for Outstanding Contributions to Clinical Chemistry in a Selected Area of Research from the […]

Brian T. Edelson honored for His Dedication to Teaching Immunology

Brian T. Edelson

Brian T. Edelson, MD, PhD, assistant professor of pathology and immunology, was presented with the Samuel R. Goldstein Leadership Award in Medical Student Education award.  Edelson has also received four Distinguished Service Teaching awards from Washington University and awards from the Burroughs Wellcome Fund and the Edward Mallinckrodt, Jr. Foundation. Recognizing outstanding teaching, the Samuel […]

Ann Gronowski Recognized by AACC

Ann Gronowski has been selected as the 2020 AACC Academy Award for Outstanding Contributions to Clinical Chemistry in a Selected Area of Research. This award recognizes especially meritorious research contributions by an individual in a specific area of clinical chemistry. The clinical chemists who have received this award have achieved national and international status for […]

Department Recognizes LGMTrainee Presentations

The department recently announced Outstanding Laboratory and Genomic Medicine Grand Rounds Presentation for the 2018-19 season. This year’s award includes a tie between Kaitlin Mitchell and Ivan Gonzalez. The award is given to a trainee or trainees giving their first-time LGM Grand Rounds presentation, with the winner(s) decided by Laboratory Genomic Medicine faculty. Winning presentations […]

Health Professions Fair Intoduces High School Students to Medicine

The Health Professions Fair, sponsored by the Office of Diversity Programs, was held on the Washington University School of Medicine campus on Tuesday, February 4. This career fair for area high school students is designed to expose them to different professions and disciplines within medicine. Fellows, Caroline Franks and Melissa Budelier attended the Health Professions […]

Jack Ladenson elected to the National Academy of Inventors

Washington University in St. Louis this year celebrates two new fellows of the National Academy of Inventors, the highest professional distinction accorded solely to academic inventors. The distinction recognizes their prolific and innovative work and their contributions, which have had tangible, positive impacts on society.

Trainees & Faculty Heading to USCAP

Trainees and faculty from the Pathology & Immunology department will soon be heading to the United States & Canadian Academy of Pathology (USCAP) annual meeting. The meeting will be held from February 29 – March 5, 2020, in Los Angeles, CA.  Click here to see a list of presenters at the event. Click here to see the […]

Grants & Notables – November and December

$60,000 in grants awarded to faculty in Pathology & Immunology Grants Rafa Sanguinetti Czepielewski, PhD, Postdoc Research Associate in the Randolph Lab, received a one-year $60,000 grant from the Lawrence C. Pakula, MD IBD Education, and Innovation Fund, entitled “Role of Mesenteric Tertiary Lymphoid Organs in Inflammatory Bowel Disease Progression and Anti-TNF Resistance”. Noteworthy Jack […]

Gordon Lab Featured in Science Magazine

Work from the lab of Jeffery Gordon, MD was recently featured in Science as a runner up for Breakthrough of The Year. This title is awarded yearly by the journal Science to recognize significant discoveries or developments in scientific research. The journal highlighted work by Arjun Raman, MD, PhD (PGY3 Clinical Pathology Resident) and others […]

Our Trainees Have the Opportunity to Attend a Multitude of Conferences

In the Department of Pathology and Immunology, we strongly support our trainees and any opportunities that come along to further their knowledge and experiences.  Recently some of our trainees had the opportunity to attend the AABB and AMP conferences.

Grants & Notables Update: September-October 2019

Over $3 million in grants awarded to faculty in Pathology & Immunology. GRANTS Cole John Ferguson, MD, Instructor in Pathology and Immunology, received a five-year $164,015 grant from The National Institutes of Health, entitled “Ubiquitin Signaling in Epigenetic Regulation of Neuronal Development”. Chang Liu, MD, PhD, Assistant Professor of Pathology and Immunology, received a two-year […]

Kipnis named BJC Investigator

Jonathan Kipnis, PhD, an internationally recognized scientific leader in how the nervous and immune systems interact in neurodegenerative, neuroinflammatory and neurodevelopmental disorders, has been named a BJC Investigator at Washington University School of Medicine in St. Louis. He will join the Department of Pathology and Immunology, with secondary appointments in the neurology, neuroscience  and neurosurgery  departments.

Clues to improve cancer immunotherapy revealed

Cancer immunotherapy drugs trigger the body’s immune system to attack tumors and have revolutionized the treatment of certain cancers, such as lymphoma, lung cancer and melanoma. Yet, while some patients respond well to the drugs, others don’t respond at all. Cancer immunologists want to change that.