18th International Workshop of Langerhans Cells
and Related Myeloid Cells of the Skin #LC2025

8:00–9:00 – Registration and Breakfast

9:00–9:15 – Opening Remarks
Eynav Klechevsky (Chair)

Session 1: Development and Subsets

Co-Chairs: James Young and Niroshana Anandasabapathy

9:15–9:45 – Ken Murphy
“DCs, poor little LC wannabes”

9:45–10:15 – Herbert Strobl
TGF-beta family signaling in Langerhans cell differentiation during health and disease

10:15–10:30 – Selected talk: Alon Raviv “GAS6 Shapes the Langerhans Cell Network in the Oral Mucosa”

10:30-11:00 – Coffee Break

11:00–11:30 – Clare L. Bennett
“Defining Langerhans cell identity”

11:30 – 11:45 – Selected Talk: Qing-Sheng Mi “Single-Cell Profiling Reveals Functionally Distinct Subsets of Murine Epidermal Langerhans Cells”

11:45 – 12:15 – Florent Ginhoux “Ontogeny of Dendritic Cells”

12:15–13:30 – Lunch Break and Poster Viewing

Session 2: LC Workshop

Co-Chairs: Balan Sreekumar and Kodi Ravichandran

13:30–15:15 – Selected Abstract Short Talks

13:30 – 13:45 – Anjelika Gasilina “Myo10-dependent leading edge coordination maintains physical coherence of migrating dendritic cells”

13:45 – 14:00 – Nirmal Parajuli – “TAK1 Controls Langerhans Cell Maintenance through MAPK-Mediated Autophagic Pathways”

14:00 – 14:15 – Sangbum Park “Dual lineages of Langerhans cells cooperate for immune barrier recovery after skin injury”

14:15 – 14:30 – Botond Igyarto “Langerhans Cells Drive Tfh and B Cell Responses Independent of Canonical Cytokine Signals” 

14:30 – 14:45 – Artem Kiselev “Identification of a pre-migratory activated Langerhans cell state and its role in skin Immunity”

14:45 – 15:00 – Haiting Wang “Disrupted cDC2 subsets balance contribute to lupus pathogenesis”

15:00 – 15:15 – Yosuke Kumamoto “CD301b+ DC-derived IL-2 dictates effector CD4T cell fate”

15:15–15:45 PM – Coffee Break and Poster Viewing

Session 3: Retention and Migration

Co-Chair: Björn Clausen and Gwen Randolph

15:45–16:15 – Björn Clausen “Cellular anchors and microtubules: Regulation of Langerhans cells by E-cadherin and post-translational tubulin modifications”

16:15–16:30 – Selected Talk: Eric Peterman “Microtubule-dependent cell polarity regulates Langerhans cell phagocytosis and directed cell migration”

16:30–17:00 – Vincent Flacher
“Epidermal maintenance of Langerhans cells relies on autophagy-regulated lipid metabolism”

17:00–17:30 – Juliana Idoyaga “Decoding the Complexity and Plasticity of Dendritic Cell Subsets”

17:30–18:00 – Gwen Randolph
“Cellular and molecular trafficking from the skin to lymph nodes and beyond”

19:00–22:00 – Welcome reception and networking at the Maryland House

8:00–9:00 – Registration and Breakfast

Session 4: Cutaneous Responses

Co-Chairs: Kenji Kabashima and Dan Kaplan 

9:00–9:30 – Marco Colonna
 “Immune tolerance: a role for Rorγt DC”

9:30–10:00 – Franca Ronchese
“Allergy induction by dermal dendritic cells”

10:00–10:15 – Selected Talk: Alexandria Wells 
“Retroelement-specific tissue resident T cells control tissue maintenance and predisposition to inflammation”

10:15–10:45 – Coffee Break

10:45-11:15 – Kodi Ravichandran
“Dendritic cells, efferocytosis, and wound repair”

11:15–11:45 – Kenji Kabashima
“Immune–nonimmune cell interaction in the development of inducible skin-associated lymphoid tissue (iSALT)”

12:00-13:00 – Lunch Break and Poster Viewing

Session 5: Neuroimmunology and related Myeloid Cells of the brain

Chair: Jonathan Kipnis and Yonatan Ganor

13:00–13:30 – Avi-Hai Hovav
“Regulation of Oral Intraepithelial Innervation by Langerhans Cells”

13:30-14:00 – Yonatan Ganor
“Neuroimmune interactions between LCs and nociceptors in health and disease”                                                                                                                           

14:00–14:30 – Dan Kaplan “Neuroimmune regulatory circuits in skin”

14:30-15:00 – Sourav Ghosh “Engineering microglial receptors to improve immunoresilience in Alzheimer’s Disease”

15:00–15:30 – Jonathan Kipnis “Diversity and function of myeloid cells of the brain’s skin”

15:30–16:00 – Coffee Break and Poster Viewing

Session 6: Infections and Skin Responses to Pathogens

Chair: Robert Modlin

16:00–16:30 – Robert Modlin 
“CD1a presents canonical peptide antigens from mycobacteria: redefining the role of Langerhans cells in skin immunity”

16:30–17:00 – Diana Dudziac 
“DC and Langerhans cell subset variations in murine skin define response to Leishmania major infection״

17:00–17:30 – Andrew Harman
“Epithelial Langerhans cells vs dendritic cells in antigen presentation and viral transmission”

17:30–17:45 – Selected Talk: Kirstie Bertram 
“Heterogeneity of LCs, DCs and macrophages in the stratified squamous epithelium of human genital tissue”

17:45-18:00 – Selected Talk: Graham Brogden 
“Langerhans cells play a key role in viral pathogenesis and immunomodulation in salivary glands”

19:00–22:00 – Conference dinner at the Missouri Botanical Garden

8:00–9:00 – Registration and Breakfast

Session 7: Myeloid Cells in Cutaneous Tumor Immunology and Immunotherapy

Co-Chairs: Eynav Klechevsky and Michael Lotze

9:00–9:30 – Carl Allen “Langerhans Cell Histiocytosis: 2025 Update on Origins and Differentiation”

9:30–10:00 – Michael Lotze “The central defect in all human cancer is lack of dendritic cells”

10:00–10:15 – Selected Talk: Siqi Zhao “HPV susceptibility driven by PU.1 mutation”

10:15–10:45 – Coffee Break

10:45–11:15 – Christophe Caux “Dendritic cells and NK cells in tumor immune surveillance”

11:15–11:45 – Niroshana Anandasabapathy “Architecting DC maturation towards tolerance and immunity.”

11:45–12:00 – Selected Talk: Joanna Bandola-Simon “Defective removal of Invariant chain peptides from MHC-II in the skin-draining lymph node suppresses tumor-antigen presentation”

12:00–12:30 – Eynav Klechevsky “Fine-Tuning Tumor Immunity by Specialized Langerhans Cells and Dendritic Cell Subsets”

12:30–12:45 – Awards Ceremony and Closing Remarks – Eynav Klechevsky *Björn Clausen to present The Niki Romani Abstract Presenter Award

Afternoon Networking Activities

13:30–16:30 – Guided Tour at the St. Louis Art Museum and Informal Closing Gathering Happy Hour with Light Hors d’Oeuvres

Join us at The Maryland House with an open bar, appetizers and networking from 7:00 – 11:00pm. Registration is required to attend. 

Join us for dinner and drinks at the Spink Pavilion at the Missouri Botanical Garden overlooking the award-winning Garden grounds, Lily Ponds and Milles sculpture garden. This is a worldwide destination location and a crowned jewel of St Louis. Registration is required to attend. 

Self-Guided Tours at the St. Louis Art Museum drinks and Hors d’oeures

*This event will take place on the last day and run from approximately 1:00pm – 3:00pm. The Saint Louis Art Museum collects, presents, interprets, and conserves works of art of the highest quality across time and cultures; educates, inspires discovery, and elevates the human spirit; preserves a legacy of artistic achievement for the people of St. Louis and the world; and engages, includes, and represents the full diversity of the St. Louis community supporting it. Registration is required to attend. 

We are asking you to join us in supporting this incredibly important workshop including both early-career and established researchers. Sponsors will be well publicized at the workshop by having their logo on our meeting website. In addition, exhibitor booths will be available to display your printed materials. Your support will directly contribute to the success of LC2025 and its mission to advance research and collaboration in this critical field.

Sponsorship tiers:

Patron Sponsor Level

• Silver Logo placement in during-event slideshow
• Silver Logo placement on in-person programs or signage
• Name listed on email invitations and event webpage

Silver Sponsor Level

• Silver Logo placement in during-event slideshow
• Silver Logo placement on in-person programs or signage
• Name listed on email invitations and event webpage
• Opportunity to host a table at the event

Gold Sponsor Level

• Gold Logo placement during-event slideshow
• Gold Logo placement on in-person programs or signage
• Name listed on email invitations and event webpage
• Opportunity to host a table at the event

Diamond Sponsor Level

• Distinguished-tier logo placement in during-event slideshow
• Recognition before featured scientific speaker as a sponsor of that segment
• Logo placement on in-person programs or signage
• Name listed on email invitations and the event webpage
• Opportunity to host a table at the event

Please contact our Events Manager Randi Lee for more information at lee.r@wustl.edu