Jonathan Kipnis, PhD

BJC Investigator, Alan A. and Edith L. Wolff Distinguished Professor of Pathology and Immunology

Additional Titles

  • Professor of Neurology, Neuroscience and Neurosurgery
  • Director, Center for Brain Immunology and Glia (BIG)

Lab Links

Education

  • BSc, Biology: Tel Aviv University, Ramat Aviv, Israel (1995-1998)
  • MSc, Neurobiology: Weizmann Institute of Science, Rehovot, Israel (1998-1999)
  • PhD, Neuroimmunology: Weizmann Institute of Science, Rehovot, Israel (1999-2004)

Recognition

  • Sir Charles Clore scholarship and award of excellence in doctoral studies, 2002
  • Representative of Israeli Student Delegation for the International Summit of the American Academy of Achievement (Dublin, Ireland), 2002
  • Representative of Israeli Student Delegation, International Summit for Nobel Prize Laureates in Medicine (Lindau), 2003
  • Distinguished Prize for excellence in doctoral studies awarded by the Israeli Parliament (Knesset), 2004
  • Prize of excellence for doctoral studies awarded by the Feinberg Graduate School, Weizmann Institute of Science, 2004
  • Vada Kinman Oldfield Alzheimer’s Research Award, University of Nebraska Medical Center, 2006
  • Robert Ader New Investigator Award, 2011
  • PsychoNeuroImmunology Research Society (PNIRS), 2011
  • Jordi Folch-Pi award, American Society for Neurochemistry, 2012
  • Distinguished Research Career Development Award, University of Virginia, 2014
  • Gutenberg Research College (GRC) fellowship, Johannes Gutenberg University of Mainz, 2015
  • Harrison Foundation Distinguished Teaching Professorship in Neuroscience, 2016
  • NIH Director’s Pioneer Award, 2018

Research Interests

Dr. Jonathan (Jony) Kipnis’s research group focuses on the complex interactions between the immune system and the central nervous system (CNS). The goal is to elucidate the cellular and molecular mechanisms underlying these interactions in neurodegenerative, neurodevelopmental, and mental disorders as well as in physiology (including healthy aging).

DBBS Affiliation

  • Immunology
  • Neuroscience

Publications

PubMed

Derecki N.C., Cardani A.N., Yang C.H., Quinnies K.M., Crihfield A., Lynch K.R., and Kipnis J (2010) Regulation of learning and memory by meningeal immunity: A key role for IL-4. J Exp Med. May 10;207(5):1067-80. Epub 2010 May 3.
Lu Z., Elliott M.R., Chen Y., Walsh J.T., Klibanov, A.I., Ravichandran K.S. and Kipnis J. (2011) Phagocytic activity of neuronal progenitors regulates adult neurogenesis. Nat Cell Biol. Jul 31;13(9):1076-83.
Walsh JT, Hendrix S, Boato F, SmirnovI, ZhengJ, LukensJR, Gadani SP, HechlerD, GölzG, RosenbergerK, Kammertöns T, Vogt J, Vogelaar C, Siffrin V, Radjavi A, Fernandez-Castaneda A, Gaultier A, Gold R, Kanneganti TD, Nitsch R, Zipp Z, and Kipnis J. (2015) MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4. J Clin Invest Feb;125(2):699-714. doi: 10.1172/JCI76210.
Gadani SP, Walsh JT, Smirnov I, Zheng J and Kipnis J. (2015) The glia-derived alarmin IL-33 orchestrates the post CNS injury immune response and promotes recovery. Neuron. Feb 18;85(4):703-9. doi: 10.1016/j.neuron.2015.01.013.
Cronk JC, Derecki NC, Ji E, Xu Y, LampanoA, Smirnov I, Baker W, Norris GT, Coddington N, Wolf Y, Klibanov AL, HarrisTH, Jung S, Litvak V, and Kipnis J. (2015) Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli. Immunity, 42, 679-691, April 21.
Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, Derecki NC, Castle D, Mandell JW, Lee KS, Harris TH, Kipnis J. (2015) Structural and functional features of central nervous system lymphatics. Nature, Jul 16;523(7560):337-41. doi: 10.1038/nature14432.
Filiano AJ, Xu Y, Tustison NJ, Marsh RL, Baker W, Smirnov I, Overall CC, Gadani SP, Turner SD, Weng Z, Peerzade SN, Chen H, Lee KS, Scott MM, Beenhakker MP, Litvak V, Kipnis J. (2016) Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour. Nature. Jul 21;535(7612):425-9.
Gadani SP, Smirnov I, Smith AT, Overall CC and Kipnis J (2017) Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury. J Exp Med., Feb;214(2):285-296. doi: 10.1084/jem.20161982.
Louveau A, Herz J, Alme MN, Salvador AF, Dong MQ, Viar KE, Herod SG, Knopp J, Setliff JC, Lupi AL, Da Mesquita S, Frost EL, Gaultier A, Harris TH, Cao R, Hu S, Lukens JR, Smirnov I, Overall CC, Oliver G, Kipnis J. (2018) CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature. Nat Neurosci. Oct;21(10):1380-1391. doi: 10.1038/s41593-018-0227-9. Epub 2018 Sep 17.
Da Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison RC, Kingsmore KM, Contarino C, Onengut-Gumuscu S, Farber E, Raper D, Viar KE, Powell RD, Baker W, Dabhi N, Bai R, Cao R, Hu S, Rich SS, Munson JM, Lopes MB, Overall CC, Acton ST, Kipnis J. (2018) Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease. Nature. Aug;560(7717):185-191. doi: 10.1038/s41586-018-0368-8. Epub 2018 Jul 25.