Jonathan Kipnis, PhD

BJC Investigator, Alan A. and Edith L. Wolff Distinguished Professor of Pathology and Immunology

Additional Titles

  • Professor of Neurology, Neuroscience and Neurosurgery
  • Director, Brain Immunology and Glia (BIG) Center

Lab Links


  • BSc, Biology: Tel Aviv University, Ramat Aviv, Israel (1995-1998)
  • MSc, Neurobiology: Weizmann Institute of Science, Rehovot, Israel (1998-1999)
  • PhD, Neuroimmunology: Weizmann Institute of Science, Rehovot, Israel (1999-2004)


  • Sir Charles Clore scholarship and award of excellence in doctoral studies, 2002
  • Representative of Israeli Student Delegation for the International Summit of the American Academy of Achievement (Dublin, Ireland), 2002
  • Representative of Israeli Student Delegation, International Summit for Nobel Prize Laureates in Medicine (Lindau), 2003
  • Distinguished Prize for excellence in doctoral studies awarded by the Israeli Parliament (Knesset), 2004
  • Prize of excellence for doctoral studies awarded by the Feinberg Graduate School, Weizmann Institute of Science, 2004
  • Vada Kinman Oldfield Alzheimer’s Research Award, University of Nebraska Medical Center, 2006
  • Robert Ader New Investigator Award, 2011
  • PsychoNeuroImmunology Research Society (PNIRS), 2011
  • Jordi Folch-Pi award, American Society for Neurochemistry, 2012
  • Distinguished Research Career Development Award, University of Virginia, 2014
  • Gutenberg Research College (GRC) fellowship, Johannes Gutenberg University of Mainz, 2015
  • Harrison Foundation Distinguished Teaching Professorship in Neuroscience, 2016
  • NIH Director’s Pioneer Award, 2018
  • NIH/NIA MERIT Award, 2020
  • Member, National Academy of Medicine, 2022

Research Interests

Dr. Jonathan (Jony) Kipnis’s research group focuses on the complex interactions between the immune system and the central nervous system (CNS). The goal is to elucidate the cellular and molecular mechanisms underlying these interactions in neurodegenerative, neurodevelopmental, and mental disorders as well as in physiology (including healthy aging).

DBBS Affiliation

  • Immunology
  • Neuroscience

Selected Publications


Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, Derecki NC, Castle D, Mandell JW, Lee KS, Harris TH, Kipnis J. (2015) Structural and functional features of central nervous system lymphatics. Nature, Jul 16; 523(7560): 337-41. doi: 10.1038/nature14432.
Filiano AJ, Xu Y, Tustison NJ, Marsh RL, Baker W, Smirnov I, Overall CC, Gadani SP, Turner SD, Weng Z, Peerzade SN, Chen H, Lee KS, Scott MM, Beenhakker MP, Litvak V, Kipnis J. (2016) Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour. Nature. Jul 21; 535(7612): 425-9.
Louveau A, Herz J, Alme MN, Salvador AF, Dong MQ, Viar KE, Herod SG, Knopp J, Setliff JC, Lupi AL, Da Mesquita S, Frost EL, Gaultier A, Harris TH, Cao R, Hu S, Lukens JR, Smirnov I, Overall CC, Oliver G, Kipnis J. (2018) CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature. Nat Neurosci. Oct; 21(10):1380-1391. doi: 10.1038/s41593-018-0227-9. Epub 2018 Sep 17.
Da Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison RC, Kingsmore KM, Contarino C, Onengut-Gumuscu S, Farber E, Raper D, Viar KE, Powell RD, Baker W, Dabhi N, Bai R, Cao R, Hu S, Rich SS, Munson JM, Lopes MB, Overall CC, Acton ST, Kipnis J. (2018) Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease. Nature. Aug;560(7717):185-191. doi: 10.1038/s41586-018-0368-8. Epub 2018 Jul 25.
Alves de Lima K, Rustenhoven J, Da Mesquita S, Wall M, Salvador AF, Smirnov I, Martelossi Cebinelli G, Mamuladze T, Baker W, Papadopoulos Z, Lopes MB, Cao WS, Xie XS, Herz J, Kipnis J. (2020) Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons. Nat Immunol. 2020 Nov; 21(11):1421-1429. doi: 10.1038/s41590-020-0776-4. Epub 2020 Sep 14. PMID: 32929273
Rustenhoven J, Drieu A, Mamuladze T, de Lima KA, Dykstra T, Wall M, Papadopoulos Z, Kanamori M, Salvador AF, Baker W, Lemieux M, Da Mesquita S, Cugurra A, Fitzpatrick J, Sviben S, Kossina R, Bayguinov P, Townsend RR, Zhang Q, Erdmann-Gilmore P, Smirnov I, Lopes MB, Herz J, Kipnis J. (2021) Functional characterization of the dural sinuses as a neuroimmune interface. Cell. Feb 18; 184(4):1000-1016.e27. doi: 10.1016/j.cell.2020.12.040. Epub 2021 Jan 27
Da Mesquita S, Papadopoulos Z, Dykstra T, Brase L, Farias FG, Wall M, Jiang H, Kodira CD, de Lima KA, Herz J, Louveau A, Goldman DH, Salvador AF, Onengut-Gumuscu S, Farber E, Dabhi N, Kennedy T, Milam MG, Baker W, Smirnov I, Rich SS; Dominantly Inherited Alzheimer Network, Benitez BA, Karch CM, Perrin RJ, Farlow M, Chhatwal JP, Holtzman DM, Cruchaga C, Harari O, Kipnis J. (2021) Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy. Nature. Apr 28. doi: 10.1038/s41586-021-03489-0. Online ahead of print.
Cugurra A, Mamuladze T, Rustenhoven J, Dykstra T, Beroshvili G, Greenberg ZJ, Baker W, Papadopoulos Z, Drieu A, Blackburn S, Kanamori M, Brioschi S, Herz J, Schuettpelz LG, Colonna M, Smirnov I, Kipnis J. (2021) Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma. Science. Jun 3: eabf7844. doi: 10.1126/science.abf7844. Online ahead of print.
Mazzitelli JA, Smyth LCD, Cross KA, Dykstra T, Sun J, Du S, Mamuladze T, Smirnov I, Rustenhoven J, Kipnis J. (2022) Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels. Nat Neurosci. 2022 May;25(5):555-560. doi: 10.1038/s41593-022-01029-1. Epub 2022 Mar 17. PMID: 35301477
Drieu A, Du S, Storck SE, Rustenhoven J, Papadopoulos Z, Dykstra T, Zhong F, Kim K, Blackburn S, Mamuladze T, Harari O, Karch CM, Bateman RJ, Perrin R, Farlow M, Chhatwal J; Dominantly Inherited Alzheimer Network, Hu S, Randolph GJ, Smirnov I, Kipnis J. (2022) Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid. Nature Nov 9. doi: 10.1038/s41586-022-05397-3. Online ahead of print. PMID: 36352225

Tracy Duckett