Jonathan Kipnis, PhD

BJC Investigator, Alan A. and Edith L. Wolff Distinguished Professor of Pathology and Immunology

Additional Titles

  • Professor of Neurology, Neuroscience and Neurosurgery
  • Director, Center for Brain Immunology and Glia (BIG)

Lab Links


  • BSc, Biology: Tel Aviv University, Ramat Aviv, Israel (1995-1998)
  • MSc, Neurobiology: Weizmann Institute of Science, Rehovot, Israel (1998-1999)
  • PhD, Neuroimmunology: Weizmann Institute of Science, Rehovot, Israel (1999-2004)


  • Sir Charles Clore scholarship and award of excellence in doctoral studies, 2002
  • Representative of Israeli Student Delegation for the International Summit of the American Academy of Achievement (Dublin, Ireland), 2002
  • Representative of Israeli Student Delegation, International Summit for Nobel Prize Laureates in Medicine (Lindau), 2003
  • Distinguished Prize for excellence in doctoral studies awarded by the Israeli Parliament (Knesset), 2004
  • Prize of excellence for doctoral studies awarded by the Feinberg Graduate School, Weizmann Institute of Science, 2004
  • Vada Kinman Oldfield Alzheimer’s Research Award, University of Nebraska Medical Center, 2006
  • Robert Ader New Investigator Award, 2011
  • PsychoNeuroImmunology Research Society (PNIRS), 2011
  • Jordi Folch-Pi award, American Society for Neurochemistry, 2012
  • Distinguished Research Career Development Award, University of Virginia, 2014
  • Gutenberg Research College (GRC) fellowship, Johannes Gutenberg University of Mainz, 2015
  • Harrison Foundation Distinguished Teaching Professorship in Neuroscience, 2016
  • NIH Director’s Pioneer Award, 2018

Research Interests

Dr. Jonathan (Jony) Kipnis’s research group focuses on the complex interactions between the immune system and the central nervous system (CNS). The goal is to elucidate the cellular and molecular mechanisms underlying these interactions in neurodegenerative, neurodevelopmental, and mental disorders as well as in physiology (including healthy aging).

DBBS Affiliation

  • Immunology
  • Neuroscience



Cugurra, A., Mamuladze, T., Rustenhoven, J., Dykstra, T., Beroshvili, G., Greenberg, Z. J., Baker, W., Papadopoulos, Z., Drieu, A., Blackburn, S., Kanamori, M., Brioschi, S., Herz, J., Schuettpelz, L. G., Colonna, M., Smirnov, I., & Kipnis, J. (2021). Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma. Science (New York, N.Y.)373(6553), eabf7844.
Da Mesquita, S., Papadopoulos, Z., Dykstra, T., Brase, L., Farias, F. G., Wall, M., Jiang, H., Kodira, C. D., de Lima, K. A., Herz, J., Louveau, A., Goldman, D. H., Salvador, A. F., Onengut-Gumuscu, S., Farber, E., Dabhi, N., Kennedy, T., Milam, M. G., Baker, W., Smirnov, I., … Kipnis, J. (2021). Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy. Nature593(7858), 255–260.
Rustenhoven, J., Drieu, A., Mamuladze, T., de Lima, K. A., Dykstra, T., Wall, M., Papadopoulos, Z., Kanamori, M., Salvador, A. F., Baker, W., Lemieux, M., Da Mesquita, S., Cugurra, A., Fitzpatrick, J., Sviben, S., Kossina, R., Bayguinov, P., Townsend, R. R., Zhang, Q., Erdmann-Gilmore, P., … Kipnis, J. (2021). Functional characterization of the dural sinuses as a neuroimmune interface. Cell184(4), 1000–1016.e27.
Alves de Lima, K., Rustenhoven, J., Da Mesquita, S., Wall, M., Salvador, A. F., Smirnov, I., Martelossi Cebinelli, G., Mamuladze, T., Baker, W., Papadopoulos, Z., Lopes, M. B., Cao, W. S., Xie, X. S., Herz, J., & Kipnis, J. (2020). Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons. Nature immunology21(11), 1421–1429.
Da Mesquita, S., Louveau, A., Vaccari, A., Smirnov, I., Cornelison, R. C., Kingsmore, K. M., Contarino, C., Onengut-Gumuscu, S., Farber, E., Raper, D., Viar, K. E., Powell, R. D., Baker, W., Dabhi, N., Bai, R., Cao, R., Hu, S., Rich, S. S., Munson, J. M., Lopes, M. B., … Kipnis, J. (2018). Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease. Nature560(7717), 185–191.
Louveau, A., Herz, J., Alme, M. N., Salvador, A. F., Dong, M. Q., Viar, K. E., Herod, S. G., Knopp, J., Setliff, J. C., Lupi, A. L., Da Mesquita, S., Frost, E. L., Gaultier, A., Harris, T. H., Cao, R., Hu, S., Lukens, J. R., Smirnov, I., Overall, C. C., Oliver, G., … Kipnis, J. (2018). CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature. Nature neuroscience21(10), 1380–1391.
Filiano, A. J., Xu, Y., Tustison, N. J., Marsh, R. L., Baker, W., Smirnov, I., Overall, C. C., Gadani, S. P., Turner, S. D., Weng, Z., Peerzade, S. N., Chen, H., Lee, K. S., Scott, M. M., Beenhakker, M. P., Litvak, V., & Kipnis, J. (2016). Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour. Nature535(7612), 425–429.
Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., Harris, T. H., & Kipnis, J. (2015). Structural and functional features of central nervous system lymphatic vessels. Nature523(7560), 337–341.
Cronk, J. C., Derecki, N. C., Ji, E., Xu, Y., Lampano, A. E., Smirnov, I., Baker, W., Norris, G. T., Marin, I., Coddington, N., Wolf, Y., Turner, S. D., Aderem, A., Klibanov, A. L., Harris, T. H., Jung, S., Litvak, V., & Kipnis, J. (2015). Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli. Immunity42(4), 679–691.
Gadani SP, Walsh JT, Smirnov I, Zheng J and Kipnis J. (2015) The glia-derived alarmin IL-33 orchestrates the post CNS injury immune response and promotes recovery. Neuron. Feb 18;85(4):703-9.

Tracy Duckett