Kenneth Murphy, MD, PhD

Eugene Opie First Centennial Professor, Pathology & Immunology

Additional Titles

  • Investigator, Howard Hughes Medical Institute

Related Links

Education

  • BA, Summa Cum Laude, Chemistry: Rice University, Houston, TX (1978)
  • MD, PhD: Johns Hopkins University School of Medicine, Baltimore, MD (1984)
  • Resident-in-Training, Department of Pathology: Washington University, Barnes Hospital, St. Louis, MO (1988)
  • Chief Resident, Anatomic Pathology: Washington University, St. Louis, MO (1998)
  • Postdoctoral Training (with Dennis Y. Loh): Washington University, St. Louis, MO (1990)

Recognition

  • 1975-1977: Board of Governors Scholar, Rice University, Houston, TX
  • 1977: Phi Beta Kappa
  • 1978: B.A. Summa Cum Laude, Rice University, Houston, TX
  • 1978: Z.W. Salsburg Memorial Award, Department of Chemistry, Rice University, Houston, TX
  • 1978-1984: Medical Scientist Training Program Award, Johns Hopkins University School of Medicine, Baltimore, MD
  • 1984: D.I. Macht Memorial Prize, Johns Hopkins University School of Medicine, Baltimore, Maryland
  • 1988-1990: Juvenile Diabetes Foundation Career Development Award
  • 2009: Distinguished Investigator Award, Washington University School of Medicine
  • 2012: William B. Coley Award for Distinguished Research in Basic Immunology, Cancer Research Institute
  • 2016: AAI-Thermo Fisher Meritorious Career Award, Thermo Fisher Scientific
  • 2016: National Academy of Sciences

Clinical Interests

Anatomic and Molecular Pathology – Autopsy Pathology

Research Interests

Selecting the correct immune response to pathogens – development of dendritic cells and lymphocyte subsets.

My laboratory examines how specialized lineages of the immune system develop to anticipate various types of infections and to generate the correct quality of immune response. Our initial focus examined the basis of CD4 T cell development into the function helper subsets, such as TH1, TH2,TH17, and so on. Our work defined the physiological basis of instructive differentiation that occurs in response to pathogens and defined the signaling pathways and transcriptional circuits involved. Our early discovery that dendritic cells and macrophages determined the direction of T cell differentiation, by their production of cytokines such as IL-12, led us to examine how myeloid cells evolved to be the decision makers for T cell differentiation in immunity. We are currently focused on defining the developmental basis for dendritic cell diversification into the functional subsets that control induction of the various types of lymphocyte effector responses. This work has practical implications for improved immunotherapy, including vaccine design. Ongoing projects can be found by reading our recently published work and review articles.

Editorial Responsibilities

2016 – Present Executive Committee, Senior Editorial Board European Journal of Immunology
2005 – Present Lead Author Janeway’s Immunobiology, Garland Science
2001 – Present Transmitting Editor International Immunology
2001 – Present Editorial Board European Journal of Immunology
2000 – Present Associate Editor Immunity
1997 – 2000 Editor Immunity

Service to the Department

2015 – Present Center for Human Immunology and Immunotherapy Program (CHiiPs) Member
2015 – Present Inaugural Siteman Investment Program Review Committee
2011 – 2012 Course master, Immunobiology I 5052 & Immunobiology II 5053
2010 – 2013 Animal Studies Committee
2009 – Present Selection Committee for Faculty Affairs
2009 – 2011 Course master, Lymphoid Organogenesis Immunology 5161
2008 – Present DBBS Evaluation Committee, Pathology and Immunology
2008 – Present Faculty Search Committee, Immunobiology
2008 – 2011 Cell Biology Search Committee
2003 – 2012 Course Master, Foundations Immunology 5051
2000 – 2007 Barnes Hospital Medical Staff, Department of Pathology
2000 – Present Immunology Student Admissions Committee
1997 – 2000 American Association of Immunologist Nominating Committee
1992 – Present Speaker Committee, Pathology and Immunology
1992 – Present Steering Committee, Immunology Program
1992 – Present DBBS Admissions Committee
1992 – 1995 Graduate School Admissions Committee

Service to the University

1997 – Present Investigator, Howard Hughes Medical Institute

DBBS Graduate Program Affiliation

  • DBBS Admissions Committee (1992-Present)
  • Director, DBBS Immunology Program (2008-2012)
  • DBBS Evaluation Committee, Pathology and Immunology (2008-2012)

Publications

PubMed Search

Haldar M, Kohyama M, So AY, KC W, Wu X, Briseno CG, Satpathy AT, Kretzer NM, Arase H, Rajasekaran NS, Wang L, Egawa T, Igarashi K, Baltimore D, Murphy TL, Murphy KM.. Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages.. Cell ;156(6):1223-34, 2014 Abstract
Wumesh KC, Satpathy AT, Rapaport AS, Briseno CG, Wu X, Albring JC, Russler-Germain EV, Kretzer NM, Durai V, Persaud SP, Edelson BT, Loschko J, Cella M, Allen PM, Nussenzweig MC, Colonna M, Sleckman BP, Murphy TL, Murphy KM. L-Myc expression by dendritic cells is required for optimal T-cell priming. Nature ;507(7491):243-7, 2014 Abstract
Satpathy AT, Briseno CG, Lee JS, Ng D, Manieri NA, KC W, Wu X, Thomas SR, Lee WL, Turkoz M, McDonald KG, Meredith MM, Song C, Guidos CJ, Newberry RD, Ouyang W, Murphy TL, Stappenbeck TS, Gommerman JL, Nussenzweig MC, Colonna M, Kopan R, Murphy KM.. Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.. Nat.Immunol.14(9):937-48., 2013 Abstract
Satpathy AT, Wu X, Albring JC, Murphy KM.. Re(de)fining the dendritic cell lineage.. Nat.Immunol.13(12):1145-54., 2012 Abstract
Tussiwand R, Lee WL, Murphy TL, Mashayekhi M, Wumesh KC, Albring JC, Satpathy AT, Rotondo JA, Edelson BT, Kretzer NM, Wu X, Weiss LA, Glasmacher E, Li P, Liao W, Behnke M, Lam SS, Aurthur CT, Leonard WJ, Singh H, Stallings CL, Sibley LD, Schreiber RD, Mur. Compensatory dendritic cell development mediated by BATF-IRF interactions.. Nature ;490(7421):502-7., 2012Abstract
Murphy TL, Tussiwand R, Murphy KM.. Specificity through cooperation: BATF-IRF interactions control immune-regulatory networks.. Nat.Rev.Immunol.13(7):499-509., 2012 Abstract
Ise W, Kohyama M, Schraml BU, Zhang T, Schwer B, Basu U, Alt FW, Tang J, Oltz EM, Murphy TL, Murphy KM.. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells.. Nat.Immunol.12(6):536-43., 2011 Abstract
Ise W, Kohyama M, Nutsch KM, Lee HM, Suri A, Unanue ER, Murphy TL, Murphy KM.. CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms.. Nat.Immunol.11(2):129-35., 2010 Abstract
Kohyama M, Ise W, Edelson BT, Wilker PR, Hildner K, Mejia C, Frazier WA, Murphy TL, Murphy KM. Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis.. Nature ;457(7227):318-21., 2009 Abstract
Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon B, Sahota G, Sim J, Mukasa R, Cemerski S, Hatton RD, Stormo GD, Weaver CT, Russell JH, Murphy TL, Murphy KM.. The AP-1 transcription factor Batf controls T(H)17 differentiation.. Nature ;460(7253):405-9., 2009 Abstract
Hildner K, Edelson BT, Purtha WE, Diamond M, Matsushita H, Kohyama M, Calderon B, Schraml BU, Unanue ER, Diamond MS, Schreiber RD, Murphy TL, Murphy KM.. Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity.. Science ;322(5904):1097-100, 2008 Abstract

Administrative Coordinator
Teresa Page
314-747-2437
paget@wustl.edu

Lab Phone: 314-362-2004
Office Location: CSRB, Room 7766