Eynav Klechevsky, PhD
Associate Professor, Pathology & Immunology
Contact
- Email: eklechevsky@wustl.edu
- Phone: 314-747-6688
Division: Immunobiology
Titles
Office of Faculty Development Representative
Education
BSc, Molecular Biochemistry (Magna Cum laude), Technion – Israel Institute of Technology, Haifa, Israel
MSc, awarded during the direct PhD program – Technion – Israel Institute of Technology, Haifa, Israel
PhD, (excellence direct PhD program) – Immunology Technion – Israel Institute of Technology, Haifa, Israel and The Baylor Institute for Immunology Research; Dallas, TX
DBBS Affiliations
Immunology Program Co-Director
Cancer Biology Program
Molecular Microbiology and Microbial Pathogenesis Program
Computational and Systems Biology Program
Research Interests
The ability to distinguish between physiological and pathogenic antigens and to make decisions about how to respond to particular pathogens or a disease condition signifies a properly functioning adaptive immune system. Dendritic cells (DCs), a diverse family of antigen-presenting cells, are required to explain how these specific responses are initiated and controlled. Our work on the immune system is focused on fundamental and translational aspects of dendritic cell biology in healthy tissue, and their aberrant functions and distribution in disease. Leveraging our broad and deep expertise in human immunology, we are addressing using human patient samples and disease models longstanding questions related to basis for the functional specialization of human DC subtypes including, the selective co-receptor and cytokine production during immune responses, T cell skewing, differentiation and involvement in disease. Our work has revealed the discovery of a new inflammatory dendritic cell type and mechanisms we have exploited to enhance immune-based treatment efficiency in cancer and autoimmunity, ultimately with the goal of harnessing these mechanisms for the development of new vaccines and immunotherapies for some of the challenging human diseases.
Selected Publications
Dendritic cells function beyond antigen presentation
Publication
Characterization of TLR9 responsiveness in cell subsets derived from in vitro pDC differentiation of hematopoietic stem and progenitor cells
Publication
Corrigendum: Characterization of TLR9 responsiveness in cell subsets derived from in vitro pDC differentiation of hematopoietic stem and progenitor cells (Frontiers in Immunology, (2025), 16, (1550397), 10.3389/fimmu.2025.1550397)
Publication
Efferocytic remodelling of pancreatic islet macrophages by limited β-cell death
Publication
Assistant
