Tom Hannan, DVM, PhD

Instructor, Pathology & Immunology

Division

  • Immunobiology

Education

  • B.S. Biology, 1989, Georgetown University
  • D.V.M. Veterinary Medicine, 1995, Tufts University Cummings School of Veterinary Medicine
  • Ph.D. Molecular Microbiology and Microbial Pathogenesis, 2008, Washington University in St. Louis

Affiliations

  • Chief Scientific Officer, Fimbrion Therapeutics, St. Louis, MO (2016-present)

Additional Links

Research Interests

  • Mucosal Immune Defense Mechanisms of the Urinary Bladder in the Context of Recurrent Urinary Tract Infections

Selected Publications

Worby CJ, Schreiber HL 4th, Straub TJ, van Dijk LR, Bronson RA, Olson BS, Pinkner JS, Obernuefemann CLP, Muñoz VL, Paharik AE, Azimzadeh PN, Walker BJ, Desjardins CA, Chou WC, Bergeron K, Chapman SB, Klim A, Manson AL, Hannan TJ, Hooton TM, Kau AL, Lai HH, Dodson KW, Hultgren SJ, Earl AM. Longitudinal multi- omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women. Nat Microbiol. 2022 May;7(5):630-639. https://pubmed.ncbi.nlm.nih.gov/35505248/
Lu Y, O’Brien VP, Livny J, Dorsey D, Bandyopadhyay N, Colonna M, Caparon MG, Roberson EDO, Hultgren SJ, Hannan TJ. Mucosal infection rewires TNFα signaling dynamics to skew susceptibility to recurrence. eLife 2019;8:e46677 https://pubmed.ncbi.nlm.nih.gov/31429405/.
O’Brien VP, Dorsey DA, Hannan TJ, Hultgren SJ. Host restriction of Escherichia coli recurrent urinary tract infection occurs in a bacterial strain-specific manner. PLoS Pathog. 2018: 14(12): e1007457. https://www.ncbi.nlm.nih.gov/pubmed/30543708
O’Brien VP, Hannan TJ, Yu L, Livny J, Roberson ED, Schwartz DJ, Souza S, Mendelsohn CL, Colonna M, Lewis AL, Hultgren SJ. A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease. Nat Microbiol. 2016: 2:16196. https://www.ncbi.nlm.nih.gov/pubmed/27798558
Goneau LW, Hannan TJ, MacPhee RA, Schwartz DJ, Macklaim JM, Gloor GB, Razvi H, Reid G, Hultgren SJ, Burton JP. Subinhibitory antibiotic therapy alters recurrent urinary tract infection pathogenesis through modulation of bacterial virulence and host immunity. MBio. 2015; 6(2):e00356-15. https://www.ncbi.nlm.nih.gov/pubmed/25827417
Nagamatsu K, Hannan TJ, Guest RL, Kostakioti M, Hadjifrangiskou M, Binkley J, Dodson K, Raivio TL, Hultgren SJ. Dysregulation of Escherichia coli α-hemolysin expression alters the course of acute and persistent urinary tract infection. Proc Natl Acad Sci U S A 2015: 112:E871-80. https://www.ncbi.nlm.nih.gov/pubmed/25675528
Hannan TJ, Roberts PL, Riehl TE, van der Post S, Binkley JM, Schwartz DJ, Miyoshi H, Mack M, Schwendener RA, Hooton TM, Stappenbeck TS, Hansson GC, Stenson WF, Colonna M, Stapleton AE, Hultgren SJ. Inhibition of cyclooxygenase-2 prevents chronic and recurrent cystitis. EBioMedicine 2014: 1(1):46-57 https://pubmed.ncbi.nlm.nih.gov/26125048/.
Totsika M*, Kostakioti M*, Hannan TJ*, Upton M, Beatson SA, Janetka JW, Hultgren SJ, Schembri MA. A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug resistant uropathogenic Escherichia coli ST131. J Infect Dis 2013: 208(6):921-8. *Contributed equally to the work. https://www.ncbi.nlm.nih.gov/pubmed/23737602
Hannan TJ, Totsika M, Mansfield KJ, Moore KH, Schembri MA, Hultgren SJ. Host-pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection. FEMS Microbiol Rev 2012: 36(3):616-48. https://www.ncbi.nlm.nih.gov/pubmed/22404313
Hannan TJ, Mysorekar IU, Hung CS, Isaacson-Schmid M, Hultgren SJ. Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection. PLoS Pathogens 2010 August: 6(8) e1001042. https://www.ncbi.nlm.nih.gov/pubmed/20811584
Hannan TJ, Mysorekar IU, Chen SL, Walker JN, Jones JM, Pinkner JS, Hultgren SJ, Seed PC. LeuX tRNA-dependent and -independent mechanisms of Escherichia coli pathogenesis in acute cystitis. Mol Microbiol 2008: 67: 116-128. https://www.ncbi.nlm.nih.gov/pubmed/18036139