Theresa Murphy, PhD

Professor, Pathology & Immunology

Education

  • BS, Summa Cum Laude, Chemistry, University of Arizona, Tucson, AZ (1978)
  • PhD, Johns Hopkins University School of medicine, Baltimore, MD (1983)
  • Postdoctoral Training (J. Thomas August), Johns Hopkins University School of medicine (1983-1984)

Recognition

  • Phi Beta Kappa, University of Arizona 1978 Summa Cum Laude, University of Arizona, 1978
  • American Institute of Chemists Award for Scholastic Achievement, American Institute of Chemists, 1978
  • American Institute of Chemists Award for Scholastic Achievement, American Institute of Chemist, 1977

Research Interests

I work in collaboration with Dr. Kenneth Murphy in the Pathology and Immunology Department at Washington University School of Medicine. Our current emphasis is on the development of dendritic cells and lymphocyte subsets. We study how the immune system selects the correct immune response to pathogens and how dendritic cells function in tumor rejection.

Publications

cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity. Ferris ST, Durai V, Wu R, Theisen DJ, Ward JP, Bern MD, Davidson JT 4th, Bagadia P, Liu T, Briseño CG, Li L, Gillanders WE, Wu GF, Yokoyama WM, Murphy TL, Schreiber RD, Murphy KM. Nature. 2020 Aug;584(7822):624-629. doi: 10.1038/s41586-020-2611-3. Epub 2020 Aug 12. PMID: 32788723 Free PMC article.
WDFY4 is required for cross-presentation in response to viral and tumor antigens. Theisen DJ, Davidson JT 4th, Briseño CG, Gargaro M, Lauron EJ, Wang Q, Desai P, Durai V, Bagadia P, Brickner JR, Beatty WL, Virgin HW, Gillanders WE, Mosammaparast N, Diamond MS, Sibley LD, Yokoyama W, Schreiber RD, Murphy TL, Murphy KM. Science. 2018 Nov 9;362(6415):694-699. doi: 10.1126/science.aat5030. PMID: 30409884 Free PMC article.
Cryptic activation of an Irf8 enhancer governs cDC1 fate specification. Durai V, Bagadia P, Granja JM, Satpathy AT, Kulkarni DH, Davidson JT 4th, Wu R, Patel SJ, Iwata A, Liu TT, Huang X, Briseño CG, Grajales-Reyes GE, Wöhner M, Tagoh H, Kee BL, Newberry RD, Busslinger M, Chang HY, Murphy TL, Murphy KM. Nat Immunol. 2019 Sep;20(9):1161-1173. doi: 10.1038/s41590-019-0450-x. Epub 2019 Aug 12. PMID: 31406378 Free PMC article.
Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Hildner K, Edelson BT, Purtha WE, Diamond M, Matsushita H, Kohyama M, Calderon B, Schraml BU, Unanue ER, Diamond MS, Schreiber RD, Murphy TL, Murphy KM. Science. 2008 Nov 14;322(5904):1097-100. doi: 10.1126/science.1164206. PMID: 19008445 Free PMC article.
High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity. Kim S, Bagadia P, Anderson DA 3rd, Liu TT, Huang X, Theisen DJ, O’Connor KW, Ohara RA, Iwata A, Murphy TL, Murphy KM. Immunity. 2020 Oct 13;53(4):759-774.e9. doi: 10.1016/j.immuni.2020.07.018. Epub 2020 Aug 13. PMID: 32795402 Free PMC article.
An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development. Bagadia P, Huang X, Liu TT, Durai V, Grajales-Reyes GE, Nitschké M, Modrusan Z, Granja JM, Satpathy AT, Briseño CG, Gargaro M, Iwata A, Kim S, Chang HY, Shaw AS, Murphy TL, Murphy KM. Nat Immunol. 2019 Sep;20(9):1174-1185. doi: 10.1038/s41590-019-0449-3. Epub 2019 Aug 12. PMID: 31406377 Free PMC article.
Compensatory dendritic cell development mediated by BATF-IRF interactions. Tussiwand R, Lee WL, Murphy TL, Mashayekhi M, KC W, Albring JC, Satpathy AT, Rotondo JA, Edelson BT, Kretzer NM, Wu X, Weiss LA, Glasmacher E, Li P, Liao W, Behnke M, Lam SS, Aurthur CT, Leonard WJ, Singh H, Stallings CL, Sibley LD, Schreiber RD, Murphy KM. Nature. 2012 Oct 25;490(7421):502-7. doi: 10.1038/nature11531. Epub 2012 Sep 19. PMID: 22992524 Free PMC article.
Batf3-Dependent Genes Control Tumor Rejection Induced by Dendritic Cells Independently of Cross-Presentation. Theisen DJ, Ferris ST, Briseño CG, Kretzer N, Iwata A, Murphy KM, Murphy TL. Cancer Immunol Res. 2019 Jan;7(1):29-39. doi: 10.1158/2326-6066.CIR-18-0138. Epub 2018 Nov 27. PMID: 30482745

Lab Phone: 314-362-8640
Office Location: CSRB, Room 7762