Takeshi Egawa, MD, PhD

Associate Professor, Pathology & Immunology

Education

  • MD, Osaka University, Japan PhD Osaka University, Japan
  • PhD, Medical Science & Immunology: Osaka University Graduate School of Medicine, Suita, Osaka, Japan (2002)
  • Postdoctoral fellowship (Dan Littman Lab): Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY

Recognition

  • Leukemia and Lymphoma Society Scholar, 2017

Research Interests

Our laboratory has a long-standing interest in genetic and epigenetic regulation of the development and functions of lymphocytes. We are studying gene regulatory network in T cells and B cells that drives requisite clonal expansion for protection against pathogen infection and cancers, support their durable long-term immunity, and protects proliferating lymphocytes and their progenitors from cancerous transformation. Specifically, we focused our research on the characterization of hierarchical dynamics of T and B cell subpopulations that support long-lasting immune responses and roles of gene expression programs initiated by the transcription factor c-MYC that drives both lymphocyte clonal expansion required for normal immune responses and tumorigenesis. In our recent studies, we have identified subpopulations of exhausted CD4 and CD8 T cells in chronic viral infection models and also the presence of a c-MYC-induced tumor suppression pathway that protects developing B cells from transformation.

Subspecialty

  • Gene Regulation during development and function of T and B lymphocytes

Twitter Handle

  • @FW14B_Red5

Service to the University

2010-presentImmunology Program, Division of Biology and Biomedical Sciences
2010-presentDevelopmental, Regenerative and Stem Cell Biology, Division of Biology and Biomedical Sciences
2011-presentImmunology Program, Qualifying examination committee
2015-presentCourse Director, Foundations in Immunology BIO5053
2015-presentCo-organizer, Immunology Work-in-progress

DDBS Affiliation

  • Immunology Developmental
  • Regenerative and Stem Cell Biology Program

Publications

Xia Y., Sandor K., Pai J.A., Daniel B., Raju S., Wu R., Hsiung S., Qi Y., Yangdon T., Okamoto M., Schreiber R.D., Murphy K.M., Satpathy A.T., Egawa T. (2021). BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4 T cell responses to persistent antigen. bioRxiv. doi: https://doi.org/10.1101/2021.08.06.455141.
Ganaie SS, Schwarz MM, McMillen CM, Price DA, Feng AX, Albe JR, Wang W, Miersch S, Orvedahl A, Cole AR, Sentmanat MF, Mishra N, Boyles DA, Koenig ZT, Kujawa MR, Demers MA, Hoehl RM, Moyle AB, Wagner ND, Stubbs SH, Cardarelli L, Teyra J, McElroy A, Gross ML, Whelan SPJ, Doench J, Cui X, Brett TJ, Sidhu SS, Virgin HW, Egawa T, Leung DW, Amarasinghe GK, Hartman AL. Lrp1 is a host entry factor for Rift Valley fever virus. Cell, 2021, 184(20), 5163-5178 Tonc E, Takeuchi Y, Chou C, Xia Y, Holmgren M, Fujii C, Raju S, Chang GS, Iwamoto M, Egawa T: Unexpected suppression of tumorigenesis by c-MYC via TFAP4-dependent restriction of stemness in B lymphocytes. Blood, 2021, Jul 20;. doi: 10.1182/blood.2021011711. [Epub ahead of print] PubMed PMID: 34283887.
Raju S, Xia Y, Daniel B, Yost KE, Bradshaw E, Tonc E, Verbaro DJ, Kometani K, Yokoyama WM, Kurosaki T, Satpathy AT, Egawa T: Identification of a T-bethi quiescent exhausted CD8 T cell subpopulation that can differentiate into TIM3+ CX3CR1+ effectors and memory-like cells. J Immunol. 2021, Jun 4;. doi: 10.4049/jimmunol.2001348. [Epub ahead of print] PubMed PMID: 34088768; NIHMSID:NIHMS1695122.
Zegarra-Ruiz DF, Kim D, Norwood K, Majumdar S, Wu W-J, Hill AA, Saldana-Morales FB, Egawa T, Longman RS, Kim M, Bettini ML, Diehl GE: Thymic development of gut microbiota-specific T cells. Nature, 2021 Jun;594(7863):413-417. doi: 10.1038/s41586-021-03531-1. Epub 2021 May 12. PubMed PMID: 33981034; PubMed Central PMCID: PMC8323488. Bartleson JM, Viehmann Milam AA, Donermeyer DL, Horvath S, Xia Y, Egawa T, Allen PM: Strength of tonic T cell receptor signaling instructs T follicular helper cell-fate decisions. Nat Immunol. 2020; 21(11):1384-1396. doi: 10.1038/s41590-020-0781-7. PMID: 32989327. PMCID: PMC7578106.
Raju S, Verbaro DJ, Egawa T: PD-1 Signaling Promotes Control of Chronic Viral Infection by Restricting Type-I-Interferon-Mediated Tissue Damage. Cell Rep. 2019;29(9):2556-2564.e3. PMID: 31775026. PMCID: PMC6894421. Raju S, Kometani K, Kurosaki T, Shaw AS, Egawa T: The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection. PLoS Pathogen. 2018;14(5):e1007053.doi:10.1371/journal.ppat.1007053. eCollection 2018 May. PMID: 29734372. PMCID: PMC5957453.
Inoue T, Shinnakasu R, Ise W, Kawai C, Egawa T, Kurosaki T: The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help. J Exp Med. 2017;214(4):1181-1198. PMID: 28351982. PMCID: PMC5379976.
Chou C, Verbaro DJ, Tonc E, Holmgren M, Cella M, Colonna M, Bhattacharya D, Egawa T: The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses. Immunity. 2016;20;45(3):570-582. PMID: 27566940. PMCID: PMC5037962.

Assistant
Jennifer Schwierjohn
314-362-3056
j.schwierjohn@wustl.edu

Lab Phone: 314-362-8776
Office Location: CSRB, Room 7719