Education

Research Interests

Early and throughout my research career, I have focused on generating genetically engineered mice. Much of this work has involved gene targeting in embryonic stem cells, including the generation of germline competent embryonic stem cells from C57BL/6J mice. Like most, our lab is now primarily using CRISPR technology to genetically engineer mice in collaboration with GEiC and the Pathology Transgenic, Knockout and Microinjection core. We also generate bacterial artificial chromosome as well as conventional transgenic mice and routinely obtain mice from other laboratories, repositories, and commercial sources. Given this, the main emphasis of my current work in the lab is to design and implement genotyping protocols as well as to plan/carry out breeding programs that yield experimental cohorts of mice with the required genotypes, adequately controlled for environmental factors, particularly the microbiota. Breeding projects encompass collaborations with companies and distribution of mice to the community. In addition, I help write grant proposals involving design, generation and use of knockout mice, reporter mice and mouse models of diseases.

Selected Publications

Assistant

Elizabeth Moore

Administrative Office Supervisor