Simone Brioschi, PhD

Division

• Immunobiology

Education

• MS: Biotechnology, University of Milano-Bicocca, Italy
• PhD: Biology, University of Freiburg, Germany

Specialization

• Neuroimmunology

Research Lab Website

• Colonna Lab

Research Interest

My overall goal is to characterize the phenotype and functions of brain immune cells, under healthy and diseased conditions. My research has been mainly focused on brain resident macrophages (microglia), especially in the context of Alzheimer’s Disease. More recently, I started to explore the origin and functions of meningeal immune cells, located at the brain border regions.

Selected Publications

Simone Brioschi, Julia A. Belk, Vincent Peng, Martina Molgora, Patrick Fernandes Rodrigues, Khai M. Nguyen, Shoutang Wang, Siling Du, Wei-Le Wang, Gary E. Grajales-Reyes, Jennifer M. Ponce, Carla M. Yuede, Qingyun Li, John M. Baer, David G. DeNardo, Susan Gilfillan, Marina Cella, Ansuman T. Satpathy, Marco Colonna. A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages. Immunity (2023); doi: 10.1016/j.immuni.2023.01.028

Shoutang Wang, Raki Sudan, Vincent Peng, Yingyue Zhou, Siling Du, Carla M. Yuede, Tingting Lei, Jinchao Hou, Zhangying Cai, Marina Cella, Khai Nguyen, Pietro L. Poliani, Wandy L. Beatty, Yun Chen, Siyan Cao, Kent Lin, Cecilia Rodrigues, Ali H. Ellebedy, Susan Gilfillan, Gordon D. Brown, David M. Holtzman, Simone Brioschi, Marco Colonna. TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways. Cell (2022); doi: 10.1016/j.cell.2022.09.033

Simone Brioschi, Wei-Le Wang, Vincent Peng, Meng Wang, Irina Shchukina, Zev J Greenberg, Jennifer K Bando, Natalia Jaeger, Rafael S Czepielewski, Amanda Swain, Denis A Mogilenko, Wandy L Beatty, Peter Bayguinov, James AJ Fitzpatrick, Laura G Schuettpelz, Catrina C Fronick, Igor Smirnov, Jonathan Kipnis, Virginia S Shapiro, Gregory F Wu, Susan Gilfillan, Marina Cella, Maxim N Artyomov, Steven H Kleinstein, Marco Colonna. Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders. Science (2021); doi: 10.1126/science.abf9277. PMCID: PMC8448524

Marco Colonna, Simone Brioschi. Neuroinflammation and neurodegeneration in human brain at single-cell resolution. Nat Rev Immunol. (2020); doi: 10.1038/s41577-019-0262-0; Simone Brioschi, Yingyue Zhou, Marco Colonna. Brain parenchymal and extraparenchymal macrophages in development, homeostasis, and disease. J Immunol. (2020); doi.org/10.4049/jimmunol.1900821. PMCID: PMC7034672

Sabine Hellwig, Simone Brioschi, Sandra Dieni, Lars Frings, Annette Masuch, Thomas Blank, Knut Biber. Altered microglia morphology and higher resilience to stress-induced depression-like behavior in CX3CR1-deficient mice. Brain Behav. Immun. (2016); doi: 10.1016/j.bbi.2015.11.008.

Simone Brioschi, Yingyue Zhou, Marco Colonna. Brain parenchymal and extraparenchymal macrophages in development, homeostasis, and disease. J Immunol. (2020); doi.org/10.4049/jimmunol.1900821. PMCID: PMC7034672