
Scott Handley, PhD
Professor, Pathology & Immunology
Contact
- Email: shandley@wustl.edu
Division: Laboratory & Genomic Medicine
Lab Phone: 314-479-3830
Office Location: CSRB, Room 8851
Education
BS: Missouri State University, Springfield, MO (1998)
PhD: Washington University, St. Louis, MO (2006)
Research Interests
For the past 15 years, I have been involved in projects devoted to the advanced understanding of how microbial ecology and invasive pathogens operate and impact human health. My view of how microbial ecology can contribute to disease comes in two forms. The first is more traditional in which the introduction of an invasive organism (pathogen) negatively impacts either the host or the other members of the microbial community. The second form is when an imbalance in the community itself leads to disease (dysbiosis). My overall research goal is to better classify and test how alterations in community membership and function contribute to disease. To do this, I utilize high-throughput sequencing technologies, computational tools and community ecology analysis. Most of this research occurs in the mammalian gastrointestinal tract, however, lessons learned should be broadly applicable to studies at other sites.
Selected Publications
Dengue virus surveillance in Nepal yields the first on-site whole genome sequences of isolates from the 2022 outbreak
Publication
HIV-associated gut microbial alterations are dependent on host and geographic context
Publication
Genomic surveillance of SARS-CoV-2 in Nepal
Publication
Type I interferon signaling in dendritic cells limits direct antigen presentation and CD8<sup>+</sup> T cell responses against an arthritogenic alphavirus
Publication
Assistant

Lori Scantlan
Administrative Coordinator III
Contact
- Email: llscantlan@wustl.edu
- Phone: 314-747-8071