Richard J. Perrin, MD, PhD

Richard J. Perrin, MD, PhD

Associate Professor, Pathology & Immunology


  • Neuropathology

Related Links


  • BS: Yale College, New Haven, CT (1992)
  • PhD: University of Illinois Urbana-Champaign, Champaign, IL (2001)
  • Medical Degree: University of Illinois – Chicago, Chicago, IL (2004)
  • Anatomic Pathology Residency: Washington University School of Medicine, St. Louis, MO (2006)
  • Neuropathology Fellowship: Washington University School of Medicine, St. Louis, MO (2008)

Board Certifications

  • Neuropathology: Board Certified
  • Anatomic Pathology: Board Certified


  • Robert Terry Award, American Association of Neuropathologists, 2013
  • Alpha Omega Alpha Medical Honor Society, 2003

Clinical Interests

  • Neuropathology

Research Interests

Novel fluid proteomic biomarkers for early diagnosis, prognosis, and staging of neurodegenerative diseases

Richard Perrin’s laboratory studies the proteomes of cerebrospinal fluid and blood to identify new biomarkers for early diagnosis, prognosis, staging and monitoring of neurodegenerative diseases.  Such biomarkers will be essential for maximizing the efficiency, shortening the duration and reducing the cost of clinical trials, and should therefore accelerate the evaluation and discovery of effective treatments.  Additionally, they may provide novel insights into neurodegenerative pathophysiology and suggest unanticipated candidate targets for therapy.


Selected Publications

The status of digital pathology and associated infrastructure within Alzheimer’s Disease Centers. Scalco R, Hamsafar Y, White CL, Schneider JA, Reichard RR, Prokop S, Perrin RJ, Nelson PT, Mooney S, Lieberman AP, Kukull WA, Kofler J, Keene CD, Kapasi A, Irwin DJ, Gutman DA, Flanagan ME, Crary JF, Chan KC, Murray ME, Dugger BN.J Neuropathol Exp Neurol. 2023 Jan 24:nlac127. doi: 10.1093/jnen/nlac127. Online ahead of print.PMID: 36692179
Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer’s disease. Wheelock MD, Strain JF, Mansfield P, Tu JC, Tanenbaum A, Preische O, Chhatwal JP, Cash DM, Cruchaga C, Fagan AM, Fox NC, Graff-Radford NR, Hassenstab J, Jack CR, Karch CM, Levin J, McDade EM, Perrin RJ, Schofield PR, Xiong C, Morris JC, Bateman RJ, Jucker M, Benzinger TLS, Ances BM, Eggebrecht AT, Gordon BA; Dominantly Inherited Alzheimer Network.Brain. 2023 Jan 10:awac498. doi: 10.1093/brain/awac498. Online ahead of print.PMID: 36625756
Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study. Millar PR, Gordon BA, Luckett PH, Benzinger TLS, Cruchaga C, Fagan AM, Hassenstab J, Perrin RJ, Schindler SE, Allegri RF, Day GS, Farlow MR, Mori H, Nübling G; Dominantly Inherited Alzheimer Network; Bateman RJ, Morris JC, Ances BM.Elife. 2023 Jan 6;12:e81869. doi: 10.7554/eLife.81869. Online ahead of print.PMID: 36607335 

First presentation with neuropsychiatric symptoms in autosomal dominant Alzheimer’s disease: the Dominantly Inherited Alzheimer’s Network Study.
O’Connor A, Rice H, Barnes J, Ryan NS, Liu KY, Allegri RF, Berman S, Ringman JM, Cruchaga C, Farlow MR, Hassenstab J, Lee JH, Perrin RJ, Xiong C, Gordon B, Levey AI, Goate A, Graff-Radford N, Levin J, Jucker M, Benzinger T, McDade E, Mori H, Noble JM, Schofield PR, Martins RN, Salloway S, Chhatwal J, Morris JC, Bateman R, Howard R, Reeves S, Fox NC; Dominantly Inherited Alzheimer Network.J Neurol Neurosurg Psychiatry. 2022 Dec 15:jnnp-2022-329843. doi: 10.1136/jnnp-2022-329843. Online ahead of print.PMID: 36522155 
Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer’s disease: a cross-sectional study. Boerwinkle AH, Gordon BA, Wisch J, Flores S, Henson RL, Butt OH, McKay N, Chen CD, Benzinger TLS, Fagan AM, Handen BL, Christian BT, Head E, Mapstone M, Rafii MS, O’Bryant S, Lai F, Rosas HD, Lee JH, Silverman W, Brickman AM, Chhatwal JP, Cruchaga C, Perrin RJ, Xiong C, Hassenstab J, McDade E, Bateman RJ, Ances BM; Alzheimer’s Biomarker Consortium-Down Syndrome; Dominantly Inherited Alzheimer Network.Lancet Neurol. 2023 Jan;22(1):55-65. doi: 10.1016/S1474-4422(22)00408-2.PMID: 36517172
Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes. Yang C, Fagan AM, Perrin RJ, Rhinn H, Harari O, Cruchaga C.Genome Med. 2022 Dec 12;14(1):140. doi: 10.1186/s13073-022-01140-9.PMID: 36510323 
CSF tau microtubule-binding region identifies pathological changes in primary tauopathies. Horie K, Barthélemy NR, Spina S, VandeVrede L, He Y, Paterson RW, Wright BA, Day GS, Davis AA, Karch CM, Seeley WW, Perrin RJ, Koppisetti RK, Shaikh F, Lago AL, Heuer HW, Ghoshal N, Gabelle A, Miller BL, Boxer AL, Bateman RJ, Sato C.Nat Med. 2022 Dec;28(12):2547-2554. doi: 10.1038/s41591-022-02075-9. Epub 2022 Nov 24.PMID: 36424467 
Neocortical Lewy Body Pathology Parallels Parkinson’s Dementia, but Not Always. Martin WRW, Younce JR, Campbell MC, Racette BA, Norris SA, Ushe M, Criswell S, Davis AA, Alfradique-Dunham I, Maiti B, Cairns NJ, Perrin RJ, Kotzbauer PT, Perlmutter JS.Ann Neurol. 2023 Jan;93(1):184-195. doi: 10.1002/ana.26542. Epub 2022 Nov 22.PMID: 36331161 

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