Molly Schroeder, PhD, FACMG

Molly Schroeder, PhD, FACMG

Associate Professor, Pathology & Immunology
Associate Division Chief, Genomic and Molecular Pathology
Medical Director, Clinical Genomics Laboratory
Section Head, Molecular Pathology
Associate Director, Laboratory Genetics and Genomics Fellowship

Division

  • Laboratory & Genomic Medicine

Additional Titles

  • Associate Division Chief, Genomic and Molecular Pathology
  • Medical Director, Clinical Genomics Laboratory
  • Section Head, Molecular Pathology
  • Associate Director, Laboratory Genetics and Genomics Fellowship

Education

  • PhD: Baylor College of Medicine, Houston, TX (2012)
  • Fellowship, Clinical Cytogenetics: Case Western Reserve University, Cleveland, OH (2015)
  • Fellowship, Clinical Molecular Genetics: Case Western Reserve University, Cleveland, OH (2015)

Board Certifications

  • American Board of Medical Genetics and Genomics, Diplomate in Clinical Cytogenetics
  • American Board of Medical Genetics and Genomics, Diplomate in Clinical Molecular Genetics

Recognition

  • Fellow, American College of Medical Genetics and Genomics

Clinical Interests

  • Cytogenomics
  • Molecular diagnostics
  • Genome-scale sequencing
  • Assay development

Selected Publications

PubMed Search
Chen C.*, Schroeder M.C.*, Kango-Singh M., Tao C., Halder G. Tumor suppression by cell competition through regulation of the Hippo pathway. Proceedings of the National Academy of Sciences USA 2012:109(2):484-489.  *Equal contribution
Schroeder M.C., Halder G. Regulation of Hippo signaling by cellular architecture and mechanical signals.  Seminars in Cell and Developmental Biology 2012:23(7):803-11.
Schroeder M.C.*, Chen C.*, Gajewski K., Halder G. A non-cell-autonomous tumor suppressor role for STAT in eliminating oncogenic scribble cells.  Oncogene 2013:32(38):4471-4479.  *Equal contribution
Deeb K.K., Bedoyan J.K., Wang R., Sremba L., Schroeder M.C., Grahame G.J., Boyer M., McCandless S.E., Kerr D.S., Zhang S. Somatic mosaicism for a novel PDHA1 mutation in a male with severe pyruvate dehydrogenase complex deficiency.  Molecular Genetics and Metabolism Reports 2014:1(1):362-367
McNulty S.N., Evenson M., Corliss M., Love-Gregory L., Schroeder M.C., Cao Y., Lee Y., Drolet B.A., Neidich J., Cottrell C.E., Heusel J.W.  Diagnostic Utility of Next Generation Sequencing for Disorders of Somatic Mosaicism- A Five-Year Cumulative Cohort. American Journal of Human Genetics, 2019:105(4):734-746.
Malinowski J., Miller D.T., Demmer L., Gannon J., Pereira E.M., Schroeder M.C., Schneuner M.T., Tsai A.C., Hickey S.E., Shen J., ACMG Professional Practice and Guidelines Committee.  Systematic evidence-based review: outcomes from exome and genome sequencing for pediatric patients with congenital anomalies or intellectual disability. Genetics in Medicine, 2020:3:1-19.
Duncavage E.J., Schroeder M.C., O’Laughlin M., Wilson R., MacMillan S., … Walter M.J., Westervelt P., DiPersio J.F., Ley T.J., Spencer D.H. Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers. New England Journal of Medicine, 2021:384:924-935
This paper was the topic of three letters to the editor, responded to in Duncavage E.J., Schroeder M.C., Spencer D.H. “Genome Sequencing in Myeloid Cancers. Reply.” New England Journal of Medicine, 2021:384:25
Cochran M., East K., Greve V., Kelly M., Kelley W., Moore T., Myers R.M., Odom K., Schroeder M.C., Bick D.  A study of elective genome sequencing and pharmacogenetic testing in an unselected population. Molecular Genetics & Genomic Medicine, 2021:9(9):e1766.
Sun L., Schroeder M.C., Hagemann I.S., Pfeifer J.D., Schwarz J.K., Grigsby P.W., Markovina S., Lin A.J. Expression of Potential Biomarker Targets by Immunohistochemistry in Cervical Carcinomas. International Journal of Gynecological Pathology, 2022:41(6);628-635.
Java A., Pozzi N., Schroeder M.C., Hu Z., Huan T., Seddon J., Atkinson J. Functional analysis of rare genetic variants in complement factor I in advanced age-related macular degeneration. Human Molecular Genetics, 2022:31(11):3683-3693.
Hou Y.C., Neidich J.A., Duncavage E.J., Spencer D.H., Schroeder M.C. Clinical whole-genome sequencing in cancer diagnosis. Human Mutation 2022:43(11)1519-1530.
Dehner C.A., Schroeder M.C., Lyu Y., Bell R., Borcherding D.C., Moon T., Hirbe A., Chrisinger J.S.A. Molecular Characterization of Multifocal Granular Cell Tumors. The American Journal of Surgical Pathology, 2023:47(3):326-332.
Hou Y.C., Evenson M.J., Corliss M.M., Mahapatra L., Aldawood A., …Krysiak K., Schroeder M.C., Heusel J.W., Neidich J.A., Cao Y. A Comparative Analysis of RAS Variants in Patients with Disorders of Somatic Mosaicism. Genetics in Medicine. Published online ahead of print November 2022.
Starosta R.T., Hou Y.C., Leestma K., Singh P., Viehl L., Manwaring L., Granadillo J.L., Schroeder M.C., Colombo J.N., Whitehead H., Dickson P.I., Hulbert M.L., Nguyen H.T. Infantile-onset Pompe disease complicated by sickle cell anemia: Case report and management considerations. Frontiers in Pediatrics 2022: Sep 28;10:944178. doi: 10.3389/fped.2022.94417

Assistant
Dani Salazar
314-362-2975
sdaniela@wustl.edu