Education

MD, University of Genova, Italy, Medicine and Surgery, 1989

University of Genova, Italy, specialization in Medical Microbiology and Virology, 1993

DBBS Affiliation

Immunology Program

Editorial Responsibilities

Service to the Department

Research Interests

My interest in the last 20 years has been to study how innate immune cells, in particular Dendritic Cells (DCs), NK cells and emerging subsets of Innate Lymphoid Cells (ILCs), respond to pathogens and how these responses are altered or can be manipulated in human diseases. My research focuses on 3 fields: 1) plasmacytoid DCs (pDCs) as a primary source of Type I interferon in response to viruses and implication of pDCs in human autoimmune diseases; 2) regulation of NK cell function by activating and inhibitory receptors; 3) ILC diversity in mucosal tissues.

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Selected Publications

WashU Medicine Profile

• Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens

  Publication

• Tissue-resident CCR2⁺ macrophage TREM-1/3 signaling is necessary for monocyte and neutrophil recruitment to injured hearts

  Publication

• Mapping of RORγt⁺ dendritic cells in human tissues establishes their preferential niche in adult lymph nodes

  Publication

• Mucosal Single-Cell Profiling of Crohn's-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets

  Publication

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Assistant

Teresa Page

Administrative Professional

Lab Phone: 314-362-0368
Office Location: BJC-IH Building, Office Suite B 8210