
Kyunghee Choi, PhD
Professor, Pathology & Immunology
Contact
- Email: kchoi@wustl.edu
- Phone: 314-362-8716
Division: Immunobiology
Education
BS, Seoul National University, Korea
MS, Seoul National University, Korea
PhD, University of Illinois at Chicago, Chicago, IL
DBBS Affiliations
Developmental, Regenerative and Stem Cell Biology Program
Immunology Program
Cancer Biology Program
Molecular Cell Biology Program
Research Interests
Hematopoietic and endothelial development
We study hematopoietic and endothelial cell development. We focus on the molecular mechanisms that control mesoderm commitment to the hematopoietic and endothelial cell lineages. Particularly, we investigate the interaction among VEGF, Flk1, and an ETS transcription factor ETV2, as these three factors play a deterministic role in the formation of hematopoietic and endothelial cells. We have expertise in hematopoietic, vascular, and stem cell biology and stem cell applications.
Hematopoiesis and angiogenesis in cancer
We study hematopoiesis and angiogenesis in the context of cancer. Particularly, we investigate mechanisms that lead to hematopoietic stem and progenitor changes in the tumor. We also investigate mechanisms by which tumor angiogenesis affects tumor immunity. We hope to apply the knowledge obtained from these studies to ultimately modulate tumor immunity and tumor growth.
Selected Publications
Enhancing tumor immunity via in vivo cDC1 reprogramming
Publication
ZBTB46 coordinates angiogenesis and immunity to control tumor outcome
Publication
Baf155 controls hematopoietic differentiation and regeneration through chromatin priming
Publication
Extramedullary hematopoiesis in cancer
Publication
Assistant

Lab Phone: 314-362-9045
Office Location: BJC-IH Building, Room 8215