Kyunghee Choi, PhD

Professor, Pathology & Immunology

Divisions

Immunobiology

Division: Immunobiology

Research Interests

Hematopoietic and endothelial development 
We study hematopoietic and endothelial cell development. We focus on the molecular mechanisms that control mesoderm commitment to the hematopoietic and endothelial cell lineages. Particularly, we investigate the interaction among VEGF, Flk1, and an ETS transcription factor ETV2, as these three factors play a deterministic role in the formation of hematopoietic and endothelial cells. We have expertise in hematopoietic, vascular, and stem cell biology and stem cell applications.

Hematopoiesis and angiogenesis in cancer
We study hematopoiesis and angiogenesis in the context of cancer. Particularly, we investigate mechanisms that lead to hematopoietic stem and progenitor changes in the tumor.  We also investigate mechanisms by which tumor angiogenesis affects tumor immunity. We hope to apply the knowledge obtained from these studies to ultimately modulate tumor immunity and tumor growth.

• Enhancing tumor immunity via in vivo cDC1 reprogramming

  Publication

• ZBTB46 coordinates angiogenesis and immunity to control tumor outcome

  Publication

• Baf155 controls hematopoietic differentiation and regeneration through chromatin priming

  Publication

• Extramedullary hematopoiesis in cancer

  Publication

Assistant

Randi Lee

Administrative Professional

Lab Phone: 314-362-9045
Office Location: BJC-IH Building, Room 8215