Katherine Schwetye, MD, PhD

Associate Professor, Pathology & Immunology

Additional Titles

  • Neuropathologist, Translational Human Neurodegenerative Research (THuNDR) Laboratory

Education

  • BA: Physics and Philosophy, Washington University 2000-2001
  • MD, PhD: Washington University 2002-2011
  • Dissertation: “Dynamic measurement of soluble human Aβ in a combined microdialysis-experimental traumatic brain injury mouse model” Mentor: David L. Brody
  • Anatomic Pathology Residency – Washington University School of Medicine, 2011-2013
  • Selective Pathology Fellowship – Washington University School of Medicine, 2013-2014
  • Neuropathology Fellowship – Washington University School of Medicine, 2014-2016

Board Certifications

  • Anatomic Pathology Board Certification, 2014-2024
  • Neuropathology Board Certification, 2016-2026

Clinical Interests

  • Neurodegenerative disease
  • Neuropathology

Publications

Hartman RE, Shah A, Fagan AM, Schwetye KE, Parsadanian M, Schulman RN, Finn MB, Holtzman DM. Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer’s disease. Neurobiol Dis. 2006 Dec; 24(3):506-15.
Brody DL, Mac Donald C, Kessens CC, Yuede C, Parsadanian M, Spinner M, Kim E, Schwetye KE, Holtzman DM, Bayly PV. Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injury. J Neurotrauma. 2007 Apr; 24(4):657-73.
Brody DL, Magnoni S, Schwetye KE, Spinner ML, Esparza TJ, Stocchetti N, Zipfel GJ, Holtzman DM. Amyloid-beta dynamics correlate with neurological status in the injured human brain. Science. 2008 Aug 29; 321(5893):1221-4.
Schwetye KE, Cirrito JR, Esparza TJ, Mac Donald CL, Holtzman DM, Brody DL. Traumatic brain injury reduces soluble extracellular amyloid-β in mice: a methodologically novel combined microdialysis-controlled cortical impact study. Neurobiol Dis. 2010 Dec; 40(3):555-64.
Miller-Thomas M, Sipe A, Connolly S, Benzinger T, McConathy J, Schwetye KE. Multimodality review of amyloid-related diseases of the central nervous system. Radiographics. 2016 Jul-Aug;36(4):1147-1163.
O’Keefe E, Schwetye KE, Nazarian J, Perrin R, Schmidt RE, Bucelli R. A 66-year-old woman with a progressive, longitudinally extensive, tract specific, myelopathy. Case Rep Neurol Med. 2016;2016:4125294. Epub 2016 Nov 21.
Soleimani-Meigooni DN, Schwetye KE, Angeles MR, Ryschkewitsch CF, Major EO, Dang X, Koralnik IJ, Schmidt RE, Clifford DB, Kuhlmann FM, Bucelli RC. JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7. J Neurovirol. 2017 Feb;23(1):141-146.
Guzmán Pérez-Carrillo GJ, Owen C, Schwetye KE, McFarlane S, Vellimana AK, Mar S, Miller-Thomas MM, Shimony JS, Smyth MD, Benzinger TLS. The use of hippocampal volumetric measurements to improve diagnostic accuracy in pediatric patients with mesial temporal sclerosis. J Neurosurg Pediatr. 2017 Jun;19(6):720-728.
Day GS, Gordon BA, Perrin RJ, Cairns NJ, Beaumont H, Schwetye K, Ferguson C, Sinha N, Bucelli R, Musiek ES, Ghoshal N, Ponisio MR, Vincent B, Mishra S, Jackson K, Morris JC, Benzinger TLS, Ances BM. In vivo [18F]-AV-1451 tau-PET imaging in sporadic Creutzfeldt-Jakob disease. Neurology. 2018 Mar 6;90(10):e896-e906.
Hassert M, Wolf KJ, Schwetye KE, DiPaolo RJ, Brien JD, Pinto AK. CD4+T cells mediate protection against Zika associated severe disease in a mouse model of infection. PLoS Pathog. 2018 Sep 13;14(9):e1007237.