Joseph P. Gaut, MD, PhD

Ladenson Professor, Pathology & Immunology
Division Chief, Anatomic and Molecular Pathology
Section Head, Genitourinary Pathology, Renal Pathology, Donor Organ Evaluation

Additional Titles

  • Associate Professor, Department of Medicine Nephrology
  • Medical Director, BJC Histology Lab
  • Section Head, Renal Pathology
  • Section Head, Genitourinary Pathology
  • Section Head, Donor Organ Evaluation

Clinical Interests

  • Autopsy
  • Electron Microscopy
  • Molecular Genetic Pathology
  • Renal Pathology

Research Interests

My research interest is in the area of acute kidney injury biomarkers. We recently identified the protein myo-inositol oxygenase (MIOX) as a renal specific, cytoplasmic protein that is abundant within the proximal renal tubules. We developed a double monoclonal sandwich immunoassay to measure MIOX in plasma, serum, and urine. Current studies are underway characterizing the utility of this unique biomarker as an early indicator of renal tubular injury.

My clinical research interests pertain to medical and transplant-related renal disease.

Selected Publications

PubMed Search

Gaut JP, Crimmins DL, Ohlendorf, MF, Lockwood CM, Griest TA, Brada NA, Hoshi M, Sato B, Hotchkiss RS, Jain S, and Ladenson JH. Development of an immunoassay for the kidney specific protein myo-inositol oxygenase, a potential biomarker of acute kidney injury. Clin Chem. 60(5):747-57, 2014
Gaut JP, Hoshi M, Jain S, Liapis H. Claudin 1 and nephrin label cellular crescents in diabetic glomerulosclerosis. Hum Pathol. 45(3):628-35, 2014
Angaswamy N, Klein C, Tiriveedhi V, Gaut J, Anwar S, Rossi A, Phelan D, Wellen JR, Shenoy S, Chapman WC, and Mohanakumar T. Immune responses to collagen-IV and fibronectin in renal transplant recipients with transplant glomerulopathy. Am J Transplant. 14(3):685-93, 2014
*Takasu O, *Gaut JP, Watanabe E, To K, Fagley E, Sato B, Jarman S, Efimov IR, Janks DL, Srivastava A, Bhayani SB, Drewry A, Swanson PE, and Hotchkiss RS. Mechanisms of cardiac and renal dysfunction in patients dying of sepsis. Am. J. Respir. Crit. Care Med. 187(5): 509-517. *co-first authors, 2013
Liapis H & Gaut JP. The renal biopsy in the genomic era. Pediatr. Nephrol. 28(8): 1207-1219, 2013
Gaut JP, Crimmins DL, Lockwood, CM, McQuillan JJ, & Ladenson JH. Expression of the Na+/K+-transporting ATPase gamma subunit FXYD2 in renal tumors. Mod. Pathol. 25(5): 716-724, 2013

Assistant
Billie Charlton
314-273-1742
billie.charlton@wustl.edu
BJCIH Room 3405