Jeffrey Gordon, MD

Dr. Robert J. Glaser Distinguished University Professor
Professor, Pathology & Immunology
Professor, Developmental Biology
Professor, Molecular Microbiology

Additional Titles

  • Director, Edison Family Center for Genome Sciences and Systems Biology

Education

  • AB: Oberlin College, Oberlin, OH
  • MD: University of Chicago, Chicago, IL

Recognition

  • Member, Association of American Physicians,1989
  • Member, National Academy of Sciences, 2001
  • Member, American Academy of Arts and Sciences, 2004
  • Member, Institute of Medicine of the National Academies, 2008
  • Association of American Medical Colleges Award for Distinguished Research in the Biomedical Sciences, 2012
  • Selman A. Waksman Award in Microbiology, National Academy of Sciences, 2013
  • Robert Koch Award, 2013
  • Passano Laureate Award, 2014
  • Member, American Philosophical Society, 2014
  • Dickson Prize in Medicine, 2014
  • King Faisal International Prize in Medicine, 2015
  • Keio Medical Science Prize, 2015
  • Steven C. Beering Award, 2016
  • Jacobaeus Prize, Novo Nordisk Foundation, 2017
  • Massry Prize, 2017
  • Sanofi-Institut Pasteur International Award for Biomedical Research, 2017
  • Louisa Gross Horwitz Prize, 2017
  • Copley Medal, The Royal Society, 2018

Research Interests

Members of my lab have developed gnotobiotic animal models, and new experimental and computational approaches to characterize the assembly, dynamic operations, functional properties, and biological effects of human gut microbial communities. We has combined these models with human studies involving twins as well as members of birth cohorts living in low-, middle-  and high-income countries representing diverse geographic locations and cultural traditions. My group is focused on addressing the global health challenges of obesity and childhood undernutrition through new understanding of the interactions between diets and the gut microbiome and new ways of promoting healthy development of the gut community during the first several years of postnatal life.


DBBS Affiliation:

  • Molecular Microbiology and Microbial Pathogenesis Program Computational and Systems
  • Biology Program Molecular Cell Biology Program Plant and Microbial Biosciences Program

Publications

Pub Med Search

Green, J.M., Barrat, M.J., Kinch, M., and Gordon, J.I. Food and microbiota in the FDA regulatory network, Science, 357: 39-40 (2017) Hibberd, M.C., Wu, M., Rodionov, D.A., Li, X., Cheng, J., Griffin, N.W., Barratt, M.J., Giannone, R.J., Hettich, R.L., Osterman, A.L., and Gordon, J.I. The effects of micronutrient deficiencies on bacterial species from the human gut microbiota. Science Translational Medicine, 9: eaal4069 (2017).
Blanton, L.V., Barratt, M.J., Charbonneau, M.R., Ahmed, T., and Gordon, J.I. Childhood undernutrition, the gut microbiota, and microbiota-directed therapeutics. Science, 352: aad9359 (2016).
Blanton, L.V., Charbonneau, M.R., Salih, T., Barratt, M.J., Venkatesh, S., Ilkaveya, O., Subramanian, S., Manary, M.J., Trehan, I., Jorgensen, J.M., Fan, Y., Henrissat, B., Leyn, S.A., Rodionov, D.A., Osterman, A.L., Maleta, K.M., Newgard, C.B., Ashorn, P., Dewey, K.G., and Gordon, J.I. Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children, Science, 351: aad3311 (2016).
Charbonneau, M.R., O’Donnell, D., Blanton, L.V., Totten, S.M., Davis, J.C.C., Barratt, M. J., Cheng, J., Guruge, J., Talcott, M., Bain, J., Muehlbauer, M.J., Ilkayeva, O., Wu, C., Struckmeyer, T., Barile, D., Mangani, C., Jorgensen, J., Fan, Y-M., Maleta, K., Dewey, K.G., Ashorn, P., Newgard, C.B., Lebrilla, C., Mills, D.A., and Gordon, J.I. Sialylated milk oligosaccharides promote microbiota-dependent growth in models of infant undernutrition. Cell, 164: 859-871 (2016).
Planer, J.D., Peng, Y., Kau, A.L., Blanton, L.V., Ndao, I.M., Tarr, P.I., Warner, B.B., and Gordon, J.I. Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice. Nature, 534: 263-266 (2016).
Wu, M., McNulty, N.P., Rodionov, D.A., Khoroshkin, M.S., Griffin, N.W., Cheng, J., Latreille, P., Kerstetter, R.A., Terrapon, N., Henrissat, B., Osterman, A.L., and Gordon, J.I. Genetic determinants of in vivo fitness and diet responsiveness in multiple human gut Bacteroides, Science, 350: aac5992 (2015).
Subramanian, S., Yatsunenko, T., Huq, S., Haque, R., Mahfuz, M., Alam, M.A., Benezra, A., DeStefano, J., Meier, M.F., Muegge, B.D., Barratt, M.J., Zhang, Q., Province, M.A., Petri, W.A., Ahmed, T., and Gordon, J.I. Persistent gut microbiota immaturity in malnourished Bangladeshi children. Nature 509: 417-421 (2014).
Ridaura, V.K., Faith, J.J., Rey, F.E., Cheng, J., Duncan, A.E., Kau, A.L., Lombard, V., Henrissat, B., Bain, J.R., Muehlbauer, M.J., Ilkayeva, O., Ursell, L.K., Clemente, J.C., Van Treuren, W., Walters, W.A., Newgard, C.B., Knight, R., Heath, A.C., and Gordon, J.I. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 341:1241214 (2013).

Assistant:

Stephanie Amen
314-362-0269
samen@wustl.edu


Lab Phone: 314-362-5443
Office Location: Couch Building, 4515 McKinley Ave., Room 4211A