Jacqueline Payton, MD, PhD

Jacqueline Payton, MD, PhD

Associate Professor, Pathology & Immunology
Co-Director, Physician Scientist Training Program


  • Laboratory & Genomic Medicine

Additional Titles

  • Co-Director, Pathology Physician Scientist Training Program
  • Associate Medical Director, Molecular Diagnostics Laboratory


  • BS: Bradley University, Peoria, IL (1996)
  • PhD: University of Illinois Urbana-Champaign, Urbana, IL (2002)
  • MD with Honors: University of Illinois Chicago College of Medicine (2004)
  • Clinical Pathology Residency: Washington University and Barnes-Jewish Hospital, St. Louis, MO (2008)

Board Certifications

  • Diplomate, American Board of Pathology, Clinical Pathology, 2008


  • Ellis Benson Award, Academy of Clinical Laboratory Physicians and Scientists (ACLPS), 2017
  • Distinguished Investigator Award, Washington University School of Medicine, 2016
  • College of American Pathologists Foundation Research Scholar Award, 2008
  • Paul E. Strandjord Young Investigator Award, Academy of Clinical Laboratory Physicians & Scientists, 2007
  • American Medical Women’s Association Janet M. Glasgow Memorial Citation, University of Illinois at Chicago College of Medicine at Urbana-Champaign, 2004
  • Scholar Award from P.E.O. Sisterhood, a philanthropic educational organization, 2003
  • Otto Saphir Award for Excellence in Pathology, University of Illinois at Chicago College of Medicine, 2003
  • Summa Cum Laude, Bradley University, Peoria, IL, 1996

Clinical Interests

  • Molecular Genetics
  • Molecular Pathology

Research Interests

The Payton Lab is a “damp” lab that integrates ‘omics level discovery with cellular, molecular, and animal experimental models to elucidate novel mechanisms of pathogenesis in hematologic malignancy and response to infection. The foundation of these efforts is the development of bioinformatic approaches and novel informatic tools to accelerate translational epigenomic studies. These efforts have led to research in three independent, yet related areas, 1) epigenomic mechanisms that drive transcriptional dysregulation in hematologic malignancy, 2) pathogen-mediated disruption of host transcriptional immune response, and 3) the role of inhibitory immune receptors in cutaneous lymphoma and bacterial infection.

DBBS Affiliation

  • Molecular Genetics and Genomics Program

Selected Publications

PubMed Search

Koues OI, Kowalewski RA, Chang LW, Pyfrom SC, Schmidt JA, Luo H, Sandoval LE, Hughes TB, Bednarski JJ, Cashen AF, Payton JE, Oltz EM. Enhancer Sequence Variants and Transcription Factor Deregulation Synergize to Construct Pathogenic Regulatory Circuits in B Cell Lymphoma. Immunity. 2015 Jan 20;42(1):186-98. PMCID: PMC4302272 *Co-corresponding authors
Luo H, Schmidt JA, Lee YS, Oltz EM, Payton JE. Targeted repression of BCL6 expression by sequence-specific chromatin modifiers kills lymphoma B cells. Leuk Lymphoma. 2017 Feb;58(2):445-456. doi: 10.1080/10428194.2016.1190973. PMID: 27268204
Huang Y, Koues OI, Zhao JY, Liu R, Pyfrom SC, Payton JE, and Oltz EM. Cis-Regulatory Circuits Regulating NEK6 Kinase Overexpression in Transformed B Cells Are Super-Enhancer-Independent. 2017. Cell Rep. 2017 Mar 21;18(12):2918-2931. doi: 10.1016/ j.celrep.2017.02.067. PMID: 28329684 *Co-corresponding authors
Andrews JA, El-Alawi M, Payton JE. Genotify: Fast, lightweight gene lookup and summarization. The Journal of Open Source Software. August 2018. 3(28):885 DOI: 10.21105/joss.00885. https://github.com/j-andrews7/Genotify PMID: 31080942
Pyfrom SC, Luo H, Payton JE. PLAIDOH: A Novel Method for Functional Prediction of Long Non-Coding RNAs Identifies Cancer-Specific LncRNA Activities. BMC Genomics. 2019. 20:137 https://github.com/sarahpyfrom/PLAIDOH. https://doi.org/10.1186/s12864-019-5497-4. PMID: 30767760.
Andrews JM, Schmidt JA, Carson KR, Musiek AC, Mehta-Shah N, Payton JE. Novel cell adhesion/migration pathways are predictive markers of HDAC inhibitor resistance in cutaneous T cell lymphoma. EBioMedicine 2019 Jul 26. pii: S2352-3964(19)30495-5. doi: 10.1016/j.ebiom.2019.07.053. PMID: 31358475.
Pyfrom SC, Quinn CC, Dorando HK, Luo H, and Payton JE. BCALM (AC099524.1) is a human B lymphocyte-specific lncRNA that modulates B cell receptor-mediated calcium signaling. Journal of Immunology. Aug 1;205(3):595-607. Epub June 22, 2020 doi: 10.4049/jimmunol.2000088. PMID: 32571842
Lay L, Stroup B, and Payton JE*. Validation and Interpretation of IGH and TCR Clonality Testing by Ion Torrent S5 NGS for Diagnosis and Disease Monitoring in B and T Cell Cancers. Practical Laboratory Medicine. doi: 10.1016/j.plabm.2020.e00191. PMID: 33304977. * Co-Guest Editor of this 2020 Special Issue on Precision Oncology
Andrews JM, Pyfrom SC, Schmidt JA, Koues OI, Kowalewski RA, Grams NR, Sun JJ, Berman LR, Duncavage EJ, Lee Y-S, Cashen AF, Oltz EM, Payton JE. Loss of synergistic transcriptional feedback loops drives diverse B-cell cancers. EBioMedicine. Sept. 2021; 71: 103559. ePub ahead of print. https://doi.org/10.1016/j.ebiom.2021.103559. PMID: 34461601
Jingjing Pei, Nina Beri, Angela J. Zou, Jared Andrews, Philipp Hubel, Valter Bergant, Rebecca D. Andrews, Kathleen C. F. Sheehan, Andreas Pichlmair, Gaya K. Amarasinghe, Jacqueline E. Payton†, and Daisy W. Leung†. Human Respiratory Syncytial Virus Non-Structural Protein NS1 enters the nucleus to modulate gene transcription. Cell Reports 2021 Oct 12;37(2):109803. doi: 10.1016/j.celrep.2021.109803. PMID: 34644581. *contributed equally to this work †Co-corresponding authors.

Jennifer Schwierjohn