Eric J. Duncavage, MD

Associate Professor, Pathology & Immunology
Section Head, Hematopathology

Education

  • Hematopathology Fellow: University of Utah/ARUP lab, Salt Lake City, UT (2009-2010)
  • Molecular Genetic Pathology Fellow: Washington University, St. Louis, MO (2008-2009)
  • Resident Physician, Anatomic and Clincal Pathology: Washington Univeristy/Barnes-Jewish Hospital, St. Louis, MO (2004-2008)
  • Medical Degree: University of Tennessee College of Medicine, Memphis, TN (1999-2004)
  • Cum Laude, Majors in Physics and Chemistry: Vanderbilt University, Nashville, TN (1994-1998)
  • Tennessee Honors Deploma: Brentwood High School, Brentwood, TN (1990-1994)

Board Certifications

  • Board Certified in Anatomic and Clinical Pathology 2008-2018
  • Board Certified in Molecular Pathology 2009-2017
  • Board Certified in Hematopathology 2010-2018
  • NY State Certificate of Qualification (Histology and Molecular) 2014-present

Recognition

  • Harry Hill Departmental Research Grant, University of Utah, 2009
  • College of American Pathologists (CAP) Research Training Grant, 2009
  • Pulmonary Pathology Society Trainee Research Award, USCAP 2009
  • American Medical Association Resident Research Grant, 2008
  • CAP Fall Informatics Meeting (APIII) Travel Grant, 2007
  • CAP Spring Informatics Meeting Travel Grant, 2007
  • University of Tennessee Alumni Achievement Research Award, 2004
  • Howard Hughes Medical Institute Predoctoral Fellowship, 2001
  • NIH Summer Medical Student Research, Fellowship Recipient, 2000
  • Honorable Mention–Tennessee Biomedical Research Fair, 1998

Clinical Interests

  • Autopsy
  • Hematopathology
  • Molecular Genetic Pathology

Research Interests

Eric’s primary research interest is the pathogenesis of myelodysplastic syndromes (MDS) including how sub-clonal hematopoiesis shapes treatment response and the use of molecular methods to monitor and risk-stratify MDS patients. He is the principal investigator on several translational science grants in MDS.

Publications

Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, Chang GS, Fulton R, O’Laughlin M, Fronick C, Magrini V, Demeter RT, Larson DE, Kulkarni S, Ozenberger BA, Welch JS, Walter MJ, Grauber TA, Westervelt P, Radich JP, Link DC, Mardis ER, DiPersio JF, Wilson RK, Ley TJ. Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia. JAMA. 2015 Aug 25;314(8):811-22
Sehn JK, Spencer DH, Pfeifer JD, Bredemeyer AJ, Cottrell CE, Abel HJ, Duncavage EJ. Occult Specimen Contamination in Routine Clinical Next-Generation Sequencing Testing. Am J Clin Pathol. 2015 Oct;144(4):667-74.
Sufficool KE, Lockwood CM, Abel HJ, Hagemann IS, Schumacher JA, Kelley TW, Duncavage EJ. T-cell clonality assessment by next-generation sequencing improves detection sensitivity in mycosis fungoides. J Am Acad Dermatol. 2015 Jun 2. pii: S0190-9622(15)01601-1.
Duncavage EJ, Tandon B. The utility of next-generation sequencing in diagnosis and monitoring of acute myeloid leukemia and myelodysplastic syndromes. Int J Lab Hematol. 2015 May;37 Suppl 1:115-21.
Shirai CL, Ley JN, White BS, Kim S, Tibbitts J, Shao J, Ndonwi M, Wadugu B, Duncavage EJ, Okeyo-Owuor T, Liu T, Griffith M, McGrath S, Magrini V, Fulton RS, Fronick C, O’Laughlin M, Graubert TA, Walter MJ. Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo. Cancer Cell. 2015 May 11;27(5):631-43.Hirbe A, Dahiya SM, Miller C, Li T, Fulton R, Zhang X, McDonald S, DeSchryver K, Duncavage E, Walrath J, Reilly KM, Abel HJ, Pekmezci M, Perry A, Ley TJ, Gutmann DH. Whole exome sequencing reveals the order of genetic changes during malignant transformation and metastasis in a single patient with NF1-plexiform neurofibroma. Clin Cancer Res. 2015 Apr 29.
Cimino PJ, Bredemeyer A, Abel HJ, Duncavage EJ. A wide spectrum of EGFR mutations in glioblastoma is detected by a single clinical oncology targeted next-generation sequencing panel. Exp Mol Pathol. 2015 Jun;98(3):568-73.
Goyal B, Duncavage EJ, Martinez D, Lewis JS Jr, Chernock RD. Next-generation sequencing of salivary high-grade neuroendocrine carcinomas identifies alterations in RB1 and the mTOR pathway. Exp Mol Pathol. 2014 Dec;97(3):572-Hagemann IS, Devarakonda S, Lockwood CM, Spencer DH, Guebert K, Bredemeyer AJ, Al-Kateb H, Nguyen TT, Duncavage EJ, Cottrell CE, Kulkarni S, Nagarajan R,Seibert K, Baggstrom M, Waqar SN, Pfeifer JD, Morgensztern D, Govindan R.Clinical next-generation sequencing in patients with non-small cell lung cancer.Cancer. 2014 Oct 24.
Xu X and Duncavage EJ. Blasts-more than meets the eye: evaluation of post-induction day 21 bone marrow in CBFB rearranged acute leukemia. Int J Clin Exp Pathol 2014;7(7).
Sehn JK, Abel HJ, and Duncavage EJ. Copy number variants in clinical next-generation sequencing data can define the relationship between simultaneous tumors in an individual patient. Exp Mol Pathol. June 1, 2014.
Chastain, E and Duncavage EJ. Clinical Prognostic Biomarkers in Chronic Lymphocytic Leukemia and Diffuse Large B-cell Lymphoma. Archives of Pathology, 2014 Sep 23.
Abel HJ AlKateb H, Cottrell CE, Bredemeyer AJ, Pritchard CC, Grossman AH, Wallender ML, Pfeifer JD, Lockwood CM and, Duncavage EJ. Detection of Gene Rearrangements in Targeted Clinical Next Generation Sequencing. J Mol Diagn. 2014 May 9. pii: S1525-1578.
Prakash V, Batanian JR, Guzman MA, Duncavage EJ, Geller TJ. MalignantTransformation of a Desmoplastic Infantile Ganglioglioma in an Infant Carrier ofa Nonsynonymous TP53 Mutation. Pediatr Neurol. 2014 Feb 22.
Cimino PJ, Zhao G, Wang D, Sehn JK, Lewis JS Jr, Duncavage EJ. Detection ofviral pathogens in high grade gliomas from unmapped next-generation sequencing data. Exp Mol Pathol. 2014 Apr 1;96(3):310-315.
Klein JL, Nguyen TT, Bien-Willner GA, Chen L, Foyil KV, Bartlett NL, Duncavage EJ, Hassan A, Frater JL, Kreisel F. CD163 Immunohistochemistry Is Superior to CD68 in Predicting Outcome in Classical Hodgkin Lymphoma. Am J Clin Pathol. 2014 Mar;141(3):381-7.
 Cimino PJ, Robirds DH, Tripp RS, Pfeifer JD, Abel HJ, and Duncavage EJ. Retinoblastoma gene mutations detected by whole exome sequencing of Merkel cell carcinoma. Modern Pathology 2014 Jan 10. Winner of F. Stephen Vogel Award for best paper published in Modern Pathology by a pathology resident.
Schumacher JA, Duncavage EJ, Mosbruger TL, Szankasi PM, Kelley TW. A Comparison of Deep Sequencing of TCRG Rearrangements vs Traditional Capillary Electrophoresis for Assessment of Clonality in T-Cell Lymphoproliferative Disorders. Am J Clin Pathol. 2014 Mar;141(3):348-59.
 Sandoval GJ, Graham DB, Gmyrek GB, Akilesh HM, Fujikawa K, Sammut B,Bhattacharya D, Srivatsan S, Kim A, Shaw AS, Yang-Iott K, Bassing CH, Duncavage E, Xavier RJ, Swat W. Novel Mechanism of Tumor Suppression by Polarity Gene Discs Large 1 (DLG1) Revealed in a Murine Model of Pediatric B-ALL. Cancer Immunol Res. 2013 Dec;1(6):426-37.
 Abel HJ, Duncavage EJ. Detection of structural DNA variation from next generation sequencing data: a review of informatic approaches. Cancer Genet. 2013 Dec;206(12):432-440
 Spencer DH, Tyagi M, Vallania F, Bredemeyer AJ, Pfeifer JD, Mitra RD,Duncavage EJ. Performance of common analysis methods for detecting low-frequency single nucleotide variants in targeted next-generation sequence data. J Mol Diagn. 2014 Jan;16(1):75-88.
Sharma MK, Phillips J, Agarwal S, Wiggins WS, Shrivastava S, Koul SB, Bhattacharjee M, Houchins CD, Kalakota RR, George B, Meyer RR, Spencer DH,Lockwood CM, Nguyen TT, Duncavage EJ, Al-Kateb H, Cottrell CE, Godala S, Lokineni R, Sawant SM, Chatti V, Surampudi S, Sunkishala RR, Darbha R, Macharla S,Milbrandt JD, Virgin HW, Mitra RD, Head RD, Kulkarni S, Bredemeyer A, Pfeifer JD, Seibert K, Nagarajan R. Clinical genomicist workstation. AMIA Summits Transl Sci Proc. 2013 Mar 18;2013:156-7.
Katherine E. Schwetye, John D. Pfeifer, Eric J. Duncavage. MED12 exon 2 mutations in uterine and extrauterine smooth muscle tumors. Human Pathology. 4 November 2013.
Cottrell CE, Al-Kateb H, Bredemeyer AJ, Duncavage EJ, Spencer DH, Abel HJ, Lockwood CM, Hagemann IS, O’Guin SM, Burcea LC, Sawyer CS, Oschwald DM, Stratman JL, Sher DA, Johnson MR, Brown JT, Cliften PF, George B, McIntosh LD, Shrivastava S, Nguyen TT, Payton JE, Watson MA, Crosby SD, Head RD, Mitra RD, Nagarajan R,Kulkarni S, Seibert K, Virgin HW 4th, Milbrandt J, Pfeifer JD. Validation of a next-generation sequencing assay for clinical molecular oncology. J Mol Diagn. 2014 Jan;16(1):89-105.
Gru AA, Kreisel F, Duncavage E, Nguyen TT, Hassan A, Frater JL . Acute EBV infection masquerading as “In-situ Follicular Lymphoma”: a pitfall in the differential diagnosis of this entity. Diagnostic Pathology. 2013 Jun 19;8(1):100.
 ames Mathews, Eric J. Duncavage, John D. Pfeifer . Characterization of translocations in mesenchymal hamartoma and undifferentiated embryonal sarcoma of the liver. Experimental and Molecular Pathology, Volume 95, Issue 3, December 2013, Pages 319-324
Spencer DH, Sehn JK, Abel HJ, Watson MW, Pfeifer PJ and Duncavage EJ. Comparison of Clinical Targeted Next-Generation Sequence Data from Formalin-Fixed and Fresh-Frozen Tissue Specimens. The Journal of Molecular Diagnostics. Volume 15, Issue 5, September 2013, Pages 623-633
Hudson J, Duncavage EJ, and Chernock R. Over expression of miR-10a and miR-375 and down regulation of YAP1 in medullary thyroid carcinoma. Exp Mol Pathol, Aug 2013.
Cimino PJ Jr, Bahler DW, Duncavage EJ. Detection of Merkel Cell Polyomavirus in Chronic Lymphocytic Leukemia T-cells. Experimental and Molecular Pathology. 2012 Sep 28.
Spencer DH, Abel HJ, Lockwood CM, Payton JE, Szankasi P, Kelley TW, Kulkarni S, Pfeifer JD, Duncavage EJ. Detection of FLT3 Internal Tandem Duplication in Targeted Short Read Length Next Generation Sequencing Data. The Journal of Molecular Diagnostics., Jan 2013.
 Herrero P, Laforest R, Shoghi K, Zhou D, Ewald G, Pfeifer J, Duncavage E, Krupp K, Mach R, Gropler R. Feasibility and Dosimetry Studies for 18F-NOS as a Potential PET Radiopharmaceutical for Inducible Nitric Oxide Synthase in Humans. Journal of Nuclear Medicine. 2012 Jun;53(6):994-1001.
Duncavage EJ, Abel HJ, Szankasi P, Kelley TW, Pfeifer JD. Targeted Next Generation Sequencing of Clinically Significant Gene Mutations and Translocations in Leukemia. Modern Pathology, 2012 Mar 16.
Duncavage EJ and Pfeifer, JD. Human Polyomaviruses 6 and 7 are not detectable in Merkel Cell Polyomavirus Negative Merkel Cell Carcinoma. Journal of Cutaneous Pathology. 2011 Oct;38(10).
Chernock RD, Duncavage EJ, Gnepp DR, El-Mofty SK, Lewis JS Jr. Absence of Merkel cell polyomavirus in primary parotid high-grade neuroendocrine carcinomas regardless of cytokeratin 20 immunophenotype. American Journal of Surgical Pathology. 2011 Dec;35(12):1806-11.
Teman CJ, Tripp SR, Perkins SL, Duncavage EJ. Merkel cell polyomavirus (MCPyV) n chronic lymphocytic leukemia/small lymphocytic lymphoma. Leukemia Resarch. 2011 May;35(5):689-92. Epub 2011 Mar 16.
Duncavage EJ, Magrini V, Becker N, Armstrong JR, Demeter RT, Wylie T, Abel HJ, Pfeifer JD. Hybrid capture and next-generation sequencing identify viral integration sites from formalin-fixed, paraffin-embedded tissue. The Journal of Molecular Diagnostics. 2011 May;13(3):325-33.
Abel HJ, Duncavage EJ, Becker N, Armstrong JR, Magrini VJ, Pfeifer JD. SLOPE: A quick and accurate method for locating non-SNP structural variation from targeted next-generation sequence data. Bioinformatics. 2010 Sep 27
Martin MG, Welch JS, Uy GL, Fehniger TA, Kulkarni S, Duncavage EJ, Walter MJ. Limited engraftment of low-risk myelodysplastic syndrome cells in NOD/SCID gamma-C chain knockout mice. Leukemia. 2010 Sep;24(9):1662-4
Duncavage EJ, Goodgame B, Sezhiyan A, Pfeifer JD, and Govindan R. MicroRNA Expression Levels to Predict Outcomes in Resected Stage I Non-small Cell Lung Cancer. Journal of Thoracic Oncology. 2010 Nov;5(11):1755-63.
Lewis JS, Duncavage EJ, Klonowski PM.   Oral Cavity Neuroendocrine Carcinoma – A Comparison Study with Cutaneous Merkel Cell Carcinoma and Other Mucosal-Based Head and Neck Neuroendocrine Carcinomas. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. 2010 Aug;110(2):209-17.
Duncavage EJ, Binh-Ming L, Wang D, Pfeifer JD. Merkel Cell Polyomavirus: A Specific Marker for Merkel Cell Carcinoma in Histologically Similar Tumors. American Journal of Surgical Pathology, 2009 Dec;33(12):1771-7.
Duncavage EJ, Zehnbauer BA, Pfeifer JD. Prevalence of Merkel cell polyomavirus in Merkel cell carcinoma. Modern Pathology. 2009 Apr;22(4):516-21.
Kuo ML, Duncavage EJ, Mathew R, den Besten W, Pei D, Naeve D, Yamamoto T, Cheng C, Sherr CJ, Roussel MF. Arf induces p53-dependent and -independent antiproliferative genes. Cancer Research 2003 Mar 1;63(5):1046-53. 

Office Location: BJH-OH Building, Room 3302