Drew Hughes, MD, PhD

Drew Hughes, MD, PhD

Assistant Professor, Pathology & Immunology


  • Anatomic & Molecular Pathology


  • BS, Mathematics, College of William & Mary
  • MD/PhD, Washington University School of Medicine
  • Residency, Clinical Pathology, Washington University School of Medicine
  • Fellowship, Molecular Genetic Pathology, Washington University School of Medicine

Clinical and Research Interests

My clinical interests are in molecular pathology, with an emphasis on molecular oncology. My research interests focus on the development of genomic technologies and machine learning to support the diagnosis and management of patients with cancer.

Board Certifications

  • Clinical Pathology
  • Molecular Genetic Pathology


Hughes AEO and Jackups R. Clinical Decision Support for Laboratory Testing. Clin Chem. 2022 Mar 4;68(3):402-412. PMID: 34871351.
Duncavage EJ, Schroeder MC, O’Laughlin M, Wilson R, MacMillan S, Bohannon A, Kruchowski S, Garza J, Du F, Hughes AEO, Robinson J, Hughes E, Heath SE, Baty JD, Neidich J, Christopher MJ, Jacoby MA, Uy GL, Fulton RS, Miller CA, Payton JE, Link DC, Walter MJ, Westervelt P, DiPersio JF, Ley TJ, Spencer DH. Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers. N Engl J Med. 2021 Mar 11;384(10):924-935. PMID: 33704937.
Perez-Cervantes C, Smith LA, Nadadur RD, Hughes AEO, Wang S, Corbo JC, Cepko C, Lonfat N, Moskowitz IP. Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types. Development. 2020 Feb 5;147(3):dev184432. PMID: 31915147.
Murphy DP, Hughes AEO, Lawrence KA, Myers CA, Corbo JC. Cis-regulatory basis of sister cell type divergence in the vertebrate retina. Elife. 2019 Oct 21;8:e48216. PMID: 31633482.
Hughes AEO, Myers CA, Corbo JC. A massively parallel reporter assay reveals context-dependent activity of homeodomain binding sites in vivo. Genome Res. 2018 Oct;28(10):1520-1531. PMID: 30158147.
Hughes AEO, Enright JM, Myers CA, Shen SQ, Corbo JC. Cell Type-Specific Epigenomic Analysis Reveals a Uniquely Closed Chromatin Architecture in Mouse Rod Photoreceptors. Sci Rep. 2017 Mar 3;7:43184. PMID: 28256534. 
Shen SQ, Myers CA, Hughes AEO, Byrne LC, Flannery JG, Corbo JC. Massively parallel cis-regulatory analysis in the mammalian central nervous system. Genome Res. 2016 Feb;26(2):238-55. PMID: 26576614.
Young AL, Wong TN, Hughes AEO, Heath SE, Ley TJ, Link DC, Druley TE. Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing. Leukemia. 2015 Jul;29(7):1608-11. PMID: 25644247.
Hughes AEO, Magrini V, Demeter R, Miller CA, Fulton R, Fulton LL, Eades WC, Elliott K, Heath S, Westervelt P, Ding L, Conrad DF, White BS, Shao J, Link DC, DiPersio JF, Mardis ER, Wilson RK, Ley TJ, Walter MJ, Graubert TA. Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing. PLoS Genet. 2014 Jul 10;10(7):e1004462. PMID: 25010716.

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