David Wang, PhD

Professor

Education

  • BS: Stanford University, Stanford, CA (1992)
  • PhD: Massachusetts Institute of Technology, Cambridge, MA (1998)

Research Interests

Research in the Wang laboratory is situated at the interface of molecular and cellular virology, genomics, and bioinformatics with the overall goal of exploiting novel viruses to elucidate fundamental biological processes and the etiologies of human disease. A major effort is dedicated to the identification of novel or unrecognized viral pathogens in both established and emerging infectious diseases. We have developed and applied state of the art NextGen sequencing platforms and bioinformatic tools for identifying novel viruses present in a variety of specimen types.

Ongoing research includes virus identification projects in respiratory tract infections, childhood diarrhea, transplant populations, and other diseases of unknown etiology. Identification of novel viral agents will serve as the launching point for additional studies focused on demonstrating disease causality and dissecting mechanisms of viral pathogenesis.  In parallel, we are leveraging our discovery of the first virus of the model organism C. elegans to identify evolutionarily conserved host factors critical for virus infection or antiviral immunity in both nematodes and mammals. 

DBBS Graduate Program Affiliation

  • Molecular Microbiology and Microbial Pathogenesis
  • Immunology
  • Computational and Systems Biology
  • Plant Microbial Biosciences

Publications

Pub Med Search

Krishnamurthy S and Wang D “Extensive conservation of prokaryotic ribosome binding site sequences in known and novel picobirnaviruses” Virology 2018 Jan 12;516:108-114. doi: 10.1016/j.virol.2018.01.006. Jiang H, Chen K, Sandoval L, Leung C, Wang D “An evolutionarily conserved pathway required for Orsay virus infection of C. elegans” mBio 2017: 8(5). pii: e00940-17. doi: 10.1128/mBio.00940-17 PMCID: PMC5587906
Zhao G, Vatanen T, Droit L, Park A, Kostic AD, Poon TW, Vlamakis H, Siljander H, Härkönen T, Hämäläinen A, Peet A, Tillman V, Ilonen J, Wang D, Knip M, Xavier RJ, Virgin HW “Intestinal Virome Changes Precede Autoimmunity in Type 1 Diabetes Susceptible Children” PNAS, 2017: 114(30):E6166-E6175. doi: 10.1073/pnas.1706359114 PMCID: PMC5544325
Janowski AB, Bauer I, Holtz L, Wang D “Propagation of astrovirus VA1, a neurotropic human astrovirus, in cell culture”. J. Virol. 2017: pii: JVI.00740-17. doi: 10.1128/JVI.00740-17. PMCID: PMC5599743
Zhao G, Wu G, Lim ES, Droit L, Krishnamurthy S, Barouch DH, Virgin HW, Wang D. VirusSeeker, a computational pipeline for virus discovery and virome composition analysis.” Virology 2017: 503:21-30. doi: 10.1016/j.virol.2017.01.005. PMCID: PMC5326578
Krishnamurthy S, Janowski AB, Zhao G, Barouch D, Wang D “Hyperexpansion of RNA bacteriophage diversity” PLoS Biology 2016: 14(3): e1002409. doi:10.1371/journal.pbio.1002409. PMCID: PMC4807089
Lim ES, Zhou Y, Zhao G, Bauer IK, Droit L, Ndao IM, Warner BB, Tarr PI, Wang D*, Holtz LR* “Early life dynamics of the human gut virome and bacterial microbiome in infants” Nature Medicine 2015: doi10.1038/nm.3950. PMCID: PMC4710368
Norman JM, Handley SA, Baldridge MT, Droit L, Liu C, Keller BC, Kambal A, Monaco, CL, Zhao G, Fleshner P, Stappenbeck TS, McGovern DPB., Keshavarzian A, Mutlu EA, Sauk J, Gevers D, Xavier R, Wang D, Parkes M, and Virgin HW “Disease-specific Alterations in the Enteric Virome in Inflammatory Bowel Disease” Cell 2015: 160: 447-60. doi: 10.1016/j.cell.2015.01.002. PMCID: PMC4312520
Felix MA, Ashe A, Pifaretti J, Wu G, Nuez I, Belicard T, Jiang Y, Zhao G, Franz CJ, Goldstein LD, Sanroman M, Miska EA, Wang D, “Natural and experimental infection of Caenorhabditis nematodes by novel viruses related to nodaviruses” PLoS Biology 2011: 9: e1000586. PMCID: PMC3026760

Lab Phone: 314-286-1124
Office Location: McDonnell Pediatric Research Building, Room 8250