Education

Recognition

Research Interests

Several poxvirus immune evasion proteins make use of a conserved β-sandwich-domain that we propose calling a “PIE scaffold”. PIE domain-containing proteins are abundant among chordopox. We estimate there may be as many as 20 separate PIE families. My current aim is to determine the function of as many PIEs as possible, to understand their role in immune evasion, and by x-ray crystallography understand how they bind so many disparate ligands.

Selected Publications

• Itaconate modulates immune responses via inhibition of peroxiredoxin 5

  Publication

• Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8

  Publication

• A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan

  Publication

• Antigen-guided depletion of anti-HLA antibody–producing cells by HLA-Fc fusion proteins

  Publication

Assistant

Jennifer Schwierjohn

Administrative Professional