Chang Liu, MD, PhD

Associate Professor, Pathology & Immunology

Additional Titles

  • Medical Director, Barnes-Jewish Hospital HLA Laboratory
  • Attending Physician, Barnes-Jewish Hospital Transfusion Medicine service


  • MD: Peking Union Medical College, Bejing, China (2004)
  • PhD, Cell & Developmental Biology: Vollum Institute, Oregon Health and Science University; Portland, OR (2010)
  • Residency, Clinical Pathology: Washington University School of Medicine; St. Louis, MO (2014)
  • Fellowship, Transfusion Medicine: Washington University School of Medicine; St. Louis, MO (2014)
  • Fellowship, Histocompatibility and Immunogenetic: Barnes-Jewish Hospital/Washington University School of Medicine, Department of Pathology and Immunology (2016)

Board Certifications

  • American Board of Pathology, Clinical Pathology, 2014
  • American Board of Pathology, Blood Banking and Transfusion Medicine, 2014
  • American Society for Histocompatibility and Immunogenetics, Laboratory Director, 2016


  • Heme Scholar, Clinical Hematology Research Career Development Program at Washington University in St. Louis, 2016
  • Best poster award, Resident Research Day, Department of Pathology and Immunology, Washington University School of Medicine, 2014
  • Abstract Achievement Award, the 53rd and 54th Annual Meeting of American Society of Hematology, 2012
  • AABB-Fenwal Transfusion Medicine Fellow Scholarship Award, the 65th Annual Meeting of AABB, 2012
  • Best grand round presentation award, Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, 2011
  • Paul E. Strandjord Young Investigator Award, the 46th Annual Meeting of Academy of Clinical Laboratory Physicians and Scientists, 2011
  • Vertex Scholar, Vertex Pharmaceuticals and Oregon Health & Science University, 2009

Clinical Interests

  • HLA testing
  • Pretransfusion testing
  • Antibody-mediated rejection
  • Alloimmunization after blood transfusion and organ transplantation

Research Interests

Methodology development in HLA typing and serology testing; HLA epitope mismatch and transplant outcome; novel therapies for HLA sensitization and antibody-mediated rejection; HLA and disease association


NCBI Bibliography

Liu C†, Xiao FZ, Hoisington-Lopez J, Lang K, Quenzel P, Duffy B, Mitra R† (2017). Accurate typing of class I Human Leukocyte Antigen class I genes by Oxford nanopore sequencing. J Mol Diagn. 2018 Apr 3. pii: S1525-1578(17)30430-0. doi:10.1016/j.jmoldx.2018.02.006. [Epub ahead of print] PubMed PMID: 29625249.
Persaud SP†, Duffy B, Phelan D, Mohanakumar T, Delos Santos R, Gaut JP, Liu C† (2017). Acute antibody-mediated rejection following kidney transplantation with development of antibodies to HLA-Bw6. Hum Immunol. 2017 Nov;78(11-12):692-698. doi:10.1016/j.humimm.2017.09.004. Epub 2017 Oct 9. PubMed PMID: 29024716.
Liu C†, Pang S, Phelan D, Brennan DC, Mohanakumar T. Quantitative evaluation of the impact of ethylenediaminetetraacetic acid treatment on single-antigen bead assay. Transplant Direct. 2017 Jul 11;3(8):e194. doi:10.1097/TXD.0000000000000709. PubMed PMID: 28795145; PubMed Central PMCID: PMC5540632.
Liu C, Schindler E, LeRoy M, Martin-Bredahl, K, Dino, M, Shah K, Dynis M, Eby CS, Grossman BJ. Effect of low hematocrit on buffy coat collection during extracorporeal photopheresis in patients with graft-versus-host disease. Vox Sang. 2017 May;112(4):379-387. doi:10.1111/vox.12504. Epub 2017 Mar 7. PubMed PMID: 28271523.
Liu C†, Duffy B, Bednarski JJ, Calhoun C, Lay L, Rundblad B, Payton JE, Mohanakumar T. Maternal T-cell engraftment interferes with HLA typing in severe combined immune deficiency. Am J Clin Pathol. 2016 Feb;145(2):251-7. doi: 10.1093/ajcp/aqv079. Epub 2016 Feb 1. PubMed PMID:26834123; PubMed Central PMCID: PMC4901308.
Liu C, Grossman BJ. Red blood cell transfusion for hematological disorders. Hematology Am Soc Hematol Educ Program. 2015;2015:454-61. doi:10.1182/asheducation-2015.1.454. Review. PubMed PMID: 26637758.
Liu C*, Yang X*, Duffy B, Mohanakumar T, Mitra RD, Zody MC, Pfeifer JD. ATHLATES: accurate typing of HLA through exome sequencing. Nucleic Acids Res. 2013 Aug;41(14):e142. doi: 10.1093/nar/gkt481. PubMed PMID: 23748956; PubMed Central PMCID: PMC3737559.
Liu C, Shah K, Dynis M, Eby CS, Grossman BJ. Linear relationship between lymphocyte counts in peripheral blood and buffy coat collected during extracorporeal photopheresis. Transfusion, 2013 Nov;53(11):2635-43. doi:10.1111/trf.12114. PubMed PMID: 23414109.
Liu C, Grossman BJ. Antibody of undetermined specificity: frequency, laboratory features and natural history. Transfusion, 2013 May;53(5):931-8. doi:10.1111/trf.12070. PubMed PMID: 23305295.
Liu C, Wetter L, Pang S, Phelan DL, Mohanakumar T, Morris GP. Cutoff values and data handling for solid-phase testing for antibodies to HLA: Effects on listing unacceptable antigens for thoracic organ transplantation. Hum Immunol. 2012 Jun;73(6):597-604. doi: 10.1016/j.humimm.2012.04.016. PubMed PMID: 22537756. (* Co-first author; † Correspondence author)

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