Laboratory Accomplishments and Spotlights
Our Hematopathology Coordinators specialize in complex and nuanced testing for the evaluation of lymph nodes, bone marrow, blood, and other hematolymphoid tissue. They assist in the mission to advance the communication and collaboration between laboratories and subspecialties that analyze hematolymphoid tissue.
The Clinical Genomics Laboratory provides clinically validated next-generation sequencing for cancer, somatic overgrowth, and a variety of constitutional diseases. With their extensive technological capabilities, they offer customized tests for clinical trials and clinical research.
With access to state-of-the-art technologies for chromosome analysis, karyotyping, chromosomal microarray analysis, and FISH testing the Cytogenomics Laboratory offers full laboratory services for prenatal, POC, constitutional, and cancer testing. The laboratory team is a dynamic group of compassionate, hard-working individuals who put their patients first.
The Dermatopathology Laboratory is a state-of-the-art histology lab that empowers healthcare providers with the tools to recommend the best treatment for their patients by delivering definitive diagnoses for skin, hair, and nail specimens. The laboratory team is a diverse, compassionate group that works hard in a high-volume, fast-paced environment.
The Pathology Assistants are highly trained, certified allied health professionals who are qualified by academic and practical training to provide services in anatomic pathology which includes comprehensive macroscopic examination and evaluation of surgical pathology specimens.
The Autopsy Technicians are trained and skilled professionals who work alongside our pathologists to assist in performing tests and examinations to determine the cause of death on deceased patients. This group of technicians is an enthusiastic and charismatic group who have a real passion for autopsy services.
Anatomical and Molecular Pathology Core Laboratory
The Anatomic and Molecular Pathology Core Laboratory provides clinical and research services in anatomic pathology with a focus in histology and immunohistochemistry. This team is made up of collaborative, hard-working, and innovative histology professionals.
A special note, one of their histology technicians, Julie Gutierrez welcomed a baby boy.
With decades of experience, the Hybridoma Center assists investigators in the generation of custom monoclonal antibody-producing B cell hybridomas.
Transgenic, Knockout, and Mico-Injection Center
The Transgenic, Knockout, and Micro-Injection Center offers a wide array of mouse embryo manipulation techniques, including cryopreservation of mouse lines, cryopreservation/storage of mouse sperm, embryo rederivation, embryos thawing, and IVF.
Electron Microscope Laboratory
The Electron Microscope Facility provides a variety of electron microscopy services for clinical and research use. These include tissue processing and embedding, preparation of one micron thick toluidine blue stained sections, and routine transmission electron microscopy for cell culture and tissue specimens. This team is small and mighty with a unique and uncommon skill set.
Clinical Support Office
The team of dedicated professionals in the Clinical Support Office are the face of Pathology & Immunology. They provide necessary customer service support and prepare all of the clinical cases received by WUSM P&I. They are a diverse group of thoughtful, detail-oriented individuals who consistently go above and beyond to provide the best customer service they can.
*Note this is list is not inclusive and just highlights some of the labs
Amarasinghe Research Laboratory
The Amarasinghe Research Laboratory’s overarching goal is to develop a mechanistic understanding of host-pathogen interactions with biological consequences to pathogenesis.
Artomov Research Laboratory
The Artomov Research Laboratory aims to discover novel fundamental biology in the areas of immunomtabolism, cancer immunology, and aging by using cross-disciplinary approaches to data generation and analysis together with in vitro and in vivo experimental biology. Most recently they have published eight papers with titles including, Immune aging at single-cell resolution, Itaconate confers tolerance to late NLRP3 inflammasome activation, Cellular and plasma proteomic determinants of COVID-19 and non-COVID-19 pulmonary diseases relative to healthy aging, and more.
Brestoff Research Laboratory
The Brestoff Research Laboratory focuses on understanding how immune cells and metabolic organs interact to maintain normal metabolism and to support adaptation to physiologic challenges such as high-fat diet feeding, changes in environmental temperature, and fasting.
Choi Research Laboratory
The Choi Research Laboratory studies the hematopoietic and endothelial cell development. They focus on the molecular mechanisms that control mesoderm commitment to the hematopoietic and endothelial cell lineages. They also study hematopoiesis and angiogenesis in the context of cancer. Particularly, they investigate mechanisms that lead to hematopoietic stem cell and progenitor changes in the tumor.
Colonna Research Laboratory
The Colonna Research Laboratory is broadly interested in innate immunity, focused on innate lymphoid cells in mucosal immunity, innate immune mechanisms in Alzheimer’s disease and neurodegeneration, and plasmacytoid dendritic cells and IFNα/β in host defense and autoimmunity.
Corbo Research Laboratory
The Corbo Research Laboratory focuses on understanding the molecular and genetic basis of color vision, focusing on how animals both see and produce colors, to elucidate the cis-regulatoy architecture of the retina and utilize this knowledge to treat blindness, and to decipher the role of cis-regulatory variation in human cognition and neuropsychiatric disease.
Edelson Research Laboratory
The Edleson Research Laboratory is a basic immunology research laboratory in the Division of Laboratory and Genomic Medicine within the Department of Pathology and Immunology. Over the last year, Dr. Brian Edleson was the recipient of the Research Distinguished Service Teaching Award for his work teaching immunology to first-year medical students. Melissa Cook, a graduate student in the Immunology program, presented her thesis work in the American Association of Immunologists Annual Meeting. Tara Bradstreet completed her 11th year in the lab and Ashlee Webber completed her 2nd.
Egawa Research Laboratory
The Egawa Research Laboratory has a long-standing interest in genetic and epigenetic regulation of the development and functions of lymphocytes. Specifically, they focused their research on the characterization of hierarchical dynamics of T and B cell subpopulations that support long-lasting immune responses and roles of gene expression programs initiated by the transcription factor c-MYC that drives both lymphocyte clonal expansion required for normal immune responses and tumorigenesis.
Ellebedy Research Laboratory
The Ellebedy Research Laboratory aims to define the cellular and molecular mechanisms that regulate humoral immune memory generation and maintenance, examine the heterogeneity of memory B cell responses that are elicited by vaccination and how do different memory B cell subsets contribute to protection, and determine the rules for eliciting broadly neutralizing B cell responses against rapidly evolving pathogens.
Fremont Research Laboratory
Fremont Research Laboratory is focused on understanding surveillance processes of the immune system, and the sabotage mechanisms used by pathogens to evade detection and host-mediated elimination. They use techniques of protein biochemistry, x-ray crystallography, and computational biology to determine the three-dimensional structures of proteins and investigate their macromolecular interactions.
Gordon Research Laboratory
The Gordon Research Laboratory aims to understand the nuances for the following question: What are the genomic and metabolic foundations of our relationships with the beneficial gut microbes? Their specific focus is on the role of the gut microbiota in defining our nutritional status. They are developing gut microbial community-targeted therapeutics to treat undernutrition in infants and children living in low-income countries, and obesity in Westernized countries.
Most recently, Dr. Gordon received the 2022 Senior Scientist Innovators in Science Award from the New York Academy of Sciences, in recognition of his outstanding contributions to the understanding of the gut microbiome.
Klechevsky Research Laboratory
The Klechevsky Research Laboratory’s goal is to integrate knowledge of human dendritic cell biology to develop novel effective immunotherapy approaches that harness dendritic cell properties to fight diseases.
Liu Research Laboratory
The Liu Research Laboratory studies the interactions of autophagy, mucosal innate immunity and diet on the physiology and pathology of the gastrointestinal system.
Mosammaparast Research Laboratory
The Mosammaparast Research Laboratory is broadly interested in understanding DNA repair mechanisms and signaling in human cells, and how these processes may be altered in tumors. The laboratory uses a variety of biochemical, cell biological, and animal model systems to answer these questions. Ultimately, their research will assist in improving diagnostic and therapeutic outcomes for cancer.
Between 2021 and 2022, the laboratory published 11 papers with titles such as, Mechanisms of damage tolerance and repair during DNA replication and Combining RNA immunoprecipitation with nucleoside mass spectrometry to analyze protein-RNA methylation dynamics.
Payton Research Laboratory
The Payton Research Laboratory focuses on the role of aberrant epigenomic patterns in cancer-specific gene dysregulation. They take an integrative approach to understanding the complex interplay of genomic and epigenomic mutations and their impact on gene regulation, employing translational, and basic biological approaches to understand the progression of hematopoietic cells from healthy to malignant.
Perrin Research Laboratory
The Perrin Research Laboratory studies the proteomes of cerebrospinal fluid and blood to identify new biomarkers for early diagnosis, prognosis, staging, and monitoring of neurodegenerative diseases.
They have recently added three new lab team members, and with new grant awards and projects, the lab continues to grow with positions coming available later this year.
A special note, one of the laboratory coordinators, Haley Bernhardt (and her husband Jared) welcomes a baby boy in June!
Randolph Research Laboratory
The Randolph Research Laboratory conducts research defining how transit cells and molecules out of tissues influences the inflammatory microenvironment. In this context, they focus on two chronic inflammatory disease settings, experimental atherosclerosis, and inflammatory bowel disease.
Schreiber Research Laboratory
The Schreiber Research Laboratory is focused on elucidating the cellular and molecular underlying natural and therapeutically induced immune responses to developing and established cancers.
This group pioneered the use of immunogenomics approaches to rapidly identify immunogenic tumor-specific neoantigens and target them therapeutically.
Van Dyken Research Laboratory
The Van Dyken Research Laboratory studies how the immune system integrates diverse signals from the external environment and host tissues to maintain homeostasis and organ health.
Watson Research Laboratory
The Watson Research Laboratory is interested in identifying the genomic alterations that contribute to tumor cell metastasis in breast and lung cancer, with the goal of developing advanced genome-based diagnostics to detect, classify, and eradicate metastatic tumor cells to improve long-term patient outcomes.