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Microbiology Update: Availability of Antimicrobial Susceptibility Testing for New Antimicrobial Agents

Infections due to antibiotic resistant bacteria are a global public health crisis. To help combat infections with multi-drug resistant bacteria, there has been a recent surge in the development of antimicrobial agents. The Barnes Jewish Hospital Microbiology Laboratory is now able to perform susceptibility testing for a number of these new antibiotics. Information regarding this testing is summarized below. Please feel free to contact Dr. Carey-Ann Burnham, Medical Director of Microbiology, or the senior microbiology fellow at 314-801-3108 with any questions.

Antibiotic (Trade Name) Antibiotic Class Testing Protocol Agent is Active Against Agent Lacks Activity Against
Ceftazidime/Avibactam (AVYCAZ®) beta-lactam/betalactamase
inhibitor
combination
CRE routinely tested,
otherwise by special
request
KPC-producing and
some OXA-producing
Enterobacteriaceae
NDM-1, other metallobeta-lactamases
Ceftolozane/
Tazobactam
(ZERBAXA®)
beta-lactam/betalactamase
inhibitor
combination
P. aeruginosa routinely
tested, otherwise by
special request
P. aeruginosa CRE, no additional
benefit against
Acinetobacter spp.
Meropenem/
Vaborbactam
(VABOMERE™)
carbapenem/betalactamase
inhibitor
combination
CRE routinely tested,
otherwise by special
request. NOTE: No P.
aeruginosa breakpoints
KPC-producing and
some OXA-producing
Enterobacteriaceae
NDM-1, other metallobeta-lactamases
no
additional benefit
against Acinetobacter
spp.
Delafloxacin
(BAXDELA™)
fluoroquinolone Special request only May be active against
ciprofloxacin-resistant S.
aureus (MRSA or MSSA); has
activity against many other
organisms
No additional benefit for
ciprofloxacin resistant P.
aeruginosa
Tedizolid
(SIVEXTRO™)
oxazolidinone Linezolid resistant
isolates or by special
request
Staphylococcus spp.,
Enterococcus spp.
Dalbavancin
(DALVANCE®
glycopeptide Vancomycin
intermediate MRSA or
by special request
Staphylococcus spp. VRE
Telavancin
(VIBATIV®)
lipoglycopeptide Vancomycin
intermediate MRSA or
by special request
Staphylococcus spp. VRE

CRE – carbapenem-resistant Enterobacteriaceae; P. aeruginosaPseudomonas aeruginosa; MRSA – methicillin-resistant
Staphylococcus aureus; methicillin-susceptible Staphylococcus aureus; S. aureus – Staphylococcus aureus; VRE- vancomycin resistant Enterococci

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