Infections due to antibiotic resistant bacteria are a global public health crisis. To help combat infections with multi-drug resistant bacteria, there has been a recent surge in the development of antimicrobial agents. The Barnes Jewish Hospital Microbiology Laboratory is now able to perform susceptibility testing for a number of these new antibiotics. Information regarding this testing is summarized below. Please feel free to contact Dr. Carey-Ann Burnham, Medical Director of Microbiology, or the senior microbiology fellow at 314-801-3108 with any questions.
| Antibiotic (Trade Name) | Antibiotic Class | Testing Protocol | Agent is Active Against | Agent Lacks Activity Against |
| Ceftazidime/Avibactam (AVYCAZ®) | beta-lactam/betalactamase inhibitor combination |
CRE routinely tested, otherwise by special request |
KPC-producing and some OXA-producing Enterobacteriaceae |
NDM-1, other metallobeta-lactamases |
| Ceftolozane/ Tazobactam (ZERBAXA®) |
beta-lactam/betalactamase inhibitor combination |
P. aeruginosa routinely tested, otherwise by special request |
P. aeruginosa | CRE, no additional benefit against Acinetobacter spp. |
| Meropenem/ Vaborbactam (VABOMERE™) |
carbapenem/betalactamase inhibitor combination |
CRE routinely tested, otherwise by special request. NOTE: No P. aeruginosa breakpoints |
KPC-producing and some OXA-producing Enterobacteriaceae |
NDM-1, other metallobeta-lactamases no additional benefit against Acinetobacter spp. |
| Delafloxacin (BAXDELA™) |
fluoroquinolone | Special request only | May be active against ciprofloxacin-resistant S. aureus (MRSA or MSSA); has activity against many other organisms |
No additional benefit for ciprofloxacin resistant P. aeruginosa |
| Tedizolid (SIVEXTRO™) |
oxazolidinone | Linezolid resistant isolates or by special request |
Staphylococcus spp., Enterococcus spp. |
|
| Dalbavancin (DALVANCE® |
glycopeptide | Vancomycin intermediate MRSA or by special request |
Staphylococcus spp. | VRE |
| Telavancin (VIBATIV®) |
lipoglycopeptide | Vancomycin intermediate MRSA or by special request |
Staphylococcus spp. | VRE |
CRE – carbapenem-resistant Enterobacteriaceae; P. aeruginosa – Pseudomonas aeruginosa; MRSA – methicillin-resistant
Staphylococcus aureus; methicillin-susceptible Staphylococcus aureus; S. aureus – Staphylococcus aureus; VRE- vancomycin resistant Enterococci