David Wang, PhD
Associate Professor, Pathology & Immunology
Associate Professor, Molecular Microbiology (dual)
Research in the Wang laboratory is situated at the interface of molecular and cellular virology, genomics and bioinformatics with the overall goal of understanding the causes of infectious diseases. As such, a major effort is dedicated to the identification of novel or unrecognized viral pathogens in both established and emerging infectious diseases. This is motivated by the fact that the etiologies of many human and animal syndromes remain cryptic; for example, ~70% of cases of viral encephalitis and ~30% of respiratory tract infections defy the most sophisticated diagnostic tests used today, suggesting that unknown agents are likely to be involved in the pathogenesis of these diseases. Furthermore, newly emerging viruses or ‘outbreaks’ such as sin nombre hantavirus (1992), nipah virus (1998) and SARS (2003) pose constant threats to public health and accentuate the need to develop novel methods for viral identification.
Toward this end, we develop and apply state of the art technologies for detection of viruses. These include pan-viral DNA microarrays and NextGen sequencing platforms aimed at identifying novel viruses present in a variety of specimen types. Ongoing research includes microarray and sequencing based pathogen identification projects in respiratory tract infections, childhood diarrhea, cancer, and acute human and animal diseases of unknown etiology. Identification of novel viral agents will serve as the launching point for additional studies focused on demonstrating disease causality and dissecting mechanisms of viral pathogenesis.
A new direction in our laboratory is the characterization of novel viruses infecting C. elegans, a robust model organism widely used in biology. Our goal is to capitalize upon our recent discovery of the first viruses known to infect C. elegans to systematically define modalities of antiviral immunity present in C. elegans.
Service to the Department
|2010 – Present||Associate Professor of Molecular Microbiology and Pathology & Immunology|
|2004 – 2010||Assistant Professor of Molecular Microbiology and Pathology & Immunology|
DBBS Graduate Program Affiliation
- Molecular Microbiology and Microbial Pathogenesis
- Computational Biology
Franz CJ, Renshaw H, Frezal L, Jiang Y, Felix MA, Wang D;. “Orsay, Santeuil and Le Blanc viruses primarily infect intestinal cells in Caenorhabditis nematodes” . Virology 2014: 448: 255, 2014
Lim ES, Reyes A, Antonio M, Saha D, Ikumapayi UN, Adeyemi M, Stine OC, Skelton R, Brennan DC, Mkakosya RS, Manary MJ, Gordon JI, Wang D;. “Discovery of STL polyomavirus, a polyomavirus of ancestral recombinant origin that encodes a unique middle T antigen by alternative splicing”. Virology 2013: 436: 295, 2013
Handley SA, Thackray LB, Zhao G, Presti R, Miller AD, Droit L, Abbink P, Maxfield LF, Kambal A, Duan E, Stanley K, Kramer J, Macri SC, Permar SC, Schmitz JE, Mansfield K, Brenchley JM, Veazey RS, Stappenbeck TS, Wang D, Barouch DH, Virgin HW;. “Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome”. Cell 151 (2012) 253, 2012
Allred AF, Renshaw H, Weaver S, Tesh RB, Wang D;. “VIPR HMM: A hidden Markov model for detecting recombination with microbial detection microarrays” . Bioinformatics 2012: 28: 2922, 2012
Siebrasse EA, Reyes A, Lim ES, Zhao G, Mkakosya RS, Manary MJ, Gordon JI, Wang D;. “Identification of MW polyomavirus, a novel polyomavirus in human stool.” . Journal of Virology 86 (2012) 10321, 2012
Felix, M.A.; Ashe A.; Pifaretti, J.; Wu, G.; Neuz, I.; Belicard, T.; Jiang, Y.; Zhao, G.; Franz, C.J.; Goldstein, L.J.; Sanroman, M.; Miska, E.A.; Wang, D.;. “Natural and experimental infection of Caenorhabditis nematodes by novel viruses related to nodaviruses”. PLoS Biology 9 (2011) e1000586, 2011
Lab Phone: 314-286-1124
Office Location: McDonnell Pediatric Research Building, Room 8250