Yi Wang, PhD

Yi Wang, PhD

Instructor, Pathology & Immunology


  • Laboratory & Genomic Medicine


  • BS: Peking University, China
  • PhD: University of Pennsylvania, Philadelphia, Pennsylvania


  • American Heart Association Research Excellence Award
  • Nachmias-Thimann Prize for Outstanding Graduate Student Research

Research Interest

I am interested in studying how microbiota-directed nutritional interventions benefit malnourished children by utilizing cutting-edge technologies including single-nuclei RNA sequencing and intestinal organoid culture.

Selected Publications

Wang Y, Chiang IL, Ohara TE, Fujii S, Cheng J, Muegge BD, Ver Heul A, Han ND, Lu Q, Xiong S, Chen F, Lai CW, Janova H, Wu R, Whitehurst CE, VanDussen K, Liu TC, Gordon JI, Sibley LD, Stappenbeck TS. Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells. Cell. 179(5):1144-1159, 2019
Wang Y, Morley MP, Lu MM, Zhou S, Lazar MA, Morrisey EE. HDAC3-Dependent Epigenetic Pathway Controls Lung Alveolar Epithelial Cell Remodeling and Spreading via miR-17-92 and TGF-β Signaling Regulation. Developmental Cell. 36(3):303-15, 2016
Wang Y, Tian Y, Morley MP, Lu MM, DeMayo FJ, Olson EN, Morrisey EE. Development and Regeneration of Sox2+ Endoderm Progenitors Is Regulated by a HDAC1/2-Bmp4/Rb1 Regulatory Pathway. Developmental Cell. 24(4):345–58, 2013
Wang X, Wang Y, Snitow ME, Stewart KM, Li S, Lu M, Morrisey EE. Expression of histone deacetylase 3 instructs alveolar type I cell differentiation by regulating a Wnt signaling niche in the lung. Developmental Biology. 414(2):161-9, 2016 *co-first authors
Wilke G, Wang Y, Ravindran S, Stappenbeck T, Witola WH, Sibley LD. In Vitro Culture of Cryptosporidium parvum Using Stem Cell-Derived Intestinal Epithelial Monolayers. Methods in Molecular Biology. 2052:351-372, 2020
Wilke G, Funkhouser-Jones LJ, Wang Y, Ravindran S, Wang Q, Beatty WL, Baldridge MT, VanDussen KL, Shen B, Kuhlenschmidt MS, Kuhlenschmidt TB, Witola WH, Stappenbeck TS, Sibley LD. A Stem-Cell-Derived Platform Enables Complete Cryptosporidium Development In Vitro and Genetic Tractability. Cell Host and Microbe. 26(1):123-134, 2019 *co-first authors
Miyoshi H, VanDussen KL, Malvin NP, Ryu SH, Wang Y, Sonnek NM, Lai CW, Stappenbeck TS.  Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. The EMBO Journal. 36(1):5-24, 2017 *co-first authors
Li S, Koziol-White C, Jude J, Jiang M, Zhao H, Cao G, Yoo E, Jester W, Morley MP, Zhou S, Wang Y, Lu MM, Panettieri RA Jr, Morrisey EE. Epithelium-generated neuropeptide Y induces smooth muscle contraction to promote airway hyperresponsiveness. Journal of Clinical Investigation. 126(5):1978-82, 2016
Li S, Wang Y, Zhang Y, Lu MM, DeMayo FJ, Dekker JD, Tucker PW, Morrisey EE. Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2. Development. 139, 2500-2509, 2012