Xinming Zhuo, PhD

Assistant Professor, Pathology and Immunology

Titles

Assistant Medical Director, Clinical Genomics Laboratory

Education

BS, Biological Science – Xiamen University

MS, Biochemistry and Molecular Biology – Xiamen University

PhD, Biochemistry and Molecular Biology – SUNY Upstate Medical University

Postdoctoral, Molecular and Human Genetics – Baylor College of Medicine

Fellowship: Laboratory Genetics and Genomics – Columbia University Medical Center

Research Interests

With a background in molecular biology technology and bioinformatics, I am passionate about leveraging these skills to enhance clinical diagnosis. My interests encompass variant classification, clinical phenotype prioritization, and the integration of multi-modal diagnostic methods that combine genomic, transcriptomic, epigenomic, and proteomic data. These efforts aim to improve diagnostic accuracy and support precision medicine. I am enthusiastic about contributing to the advancement of clinical diagnostics and introducing innovative solutions to healthcare.

Selected Publications

M. Gholampour, M. Basu, R. Swerdlow, X. Zhuo, M. Haeri, Cell-Specific Protein Expression in Alzheimer’s Disease Prefrontal Cortex. Alzheimer’s & Dementia, 2025, 21 (6), e70339

S. Leonard-Murali, C. Bhaskarla, G. Yadav, S. Maurya, C. Galiveti, J. Tobin, R. Kann, E. Ashwat, P. Murphy, A. Chakka, V. Soman, P. Cantalupo, X. Zhuo, G. Vyas, D. Kozak, L. Kelly, E. Smith, U. Chandran, Y. Hsu and U. Kammula. Uveal Melanoma Immunogenomics Predict Immunotherapy Resistance and Susceptibility. Nature Communications, 2024, 15 (1), 2863.

E. Shen, N. Leclair, K. Herlth, M. Soucy, N. Renzette, X. Zhuo, K. Kelly, G. Omerza, H. Onyiuke, I. McNeill, L. Wolansky, K. Becker, L. Li, Q. Wu, K. Bulsara, DNA Methylation Provides Diagnostic Value for Meningioma Recurrence in Clinical Practice. Acta Neurochirurgica, 2023, 165 (5):1323-1331.

D. Lee1, W. Chen1, H. Kaku1, X. Zhuo1, E. Chao, A. Soriano, A. Kuncheria, S. Flores, J. Kim, A. Rivera, F. Rigo, P. Jafar-nejad, A. Beaudet, M. Caudill, M. Xue. Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome. eLife, 2023, 12:e81892. (1 co-first author)

E. Riggs, T. Bingaman, C. Barry, A. Behlmann, K. Bluske, B. Bostwick, A. Bright, C. Chen, A. Clause, A. Dharmadhikari, M. Ganapathi, C. Gonzaga-Jauregui, A. Grant, M. Hughes, S. Kim, A. Krause, J. Liao, A. Lumaka, M. Mah, C. Maloney, S. Mohan, I. Osei-Owusu, E. Reble, O. Rennie, J. Savatt, H. Shimelis, R. Siegert, T. Sneddon, C. Thaxton, K. Toner, K. Tran, R. Webb, E. Wilcox, J. Yin, X. Zhuo, C. Martin, C. Betancur, J. Vorstman, D. Miller, C. Schaaf, Clinical validity assessment of genes frequently tested on intellectual disability/autism sequencing panels, Genetics in Medicine, 2022, 24 (9):1899-1908.

X. Zhuo, B. Knox, Interaction of human CRX and NRL in live HEK293T cells measured using fluorescence resonance energy transfer (FRET), Scientific Reports, 2022, 12, 6937.

S. Shi, C. Mahoney, P. Houdek, W. Zhao, M. Anderson, X. Zhuo, A. Beaudet, A. Sumova, T. Scammell, C. Johnson, Circadian rhythms and sleep are dependent upon expression levels of key ubiquitin ligase Ube3a, Frontiers in Behavioral Neuroscience, 2022 ,16, 837523.

X. Zhuo@, Q. Wang, L. Vossaert, R. Salman, A. Kim, I. Van den Veyver, A. Breman, A. Beaudet@, Use of amplicon-based sequencing for testing fetal identity and monogenic traits with Single Circulating Trophoblast (SCT) as one form of cell-based NIPT, Plos One, 2021, 16 (4), e0249695. (@ co-corresponding author)

X. Zhuo, K. Quann, K. Parr, R. Stewart, W. Shlomchik, S. Ito, A. Berndt, HLA-poll: an ensemble suite of human leukocyte antigen-prediction tools for whole-exome and whole-genome sequencing data, International Journal of Laboratory Hematology, 2020, 42 (5), e228-e230.

L. Vossaert, Q. Wang, R. Salman, X. Zhuo, C. Qu, D. Henke, R. Seubert, J. Chow, L. U’ren, B. Enright, J. Stilwell, E. Kaldjian, Y. Yang, C. Shaw, B. Levy, R. Wapner, A. Breman, I. Van den Veyver, A. Beaudet, Reliable detection of subchromosomal deletions and duplications using cell-based noninvasive prenatal testing, Prenatal Diagnosis, 2018,1-10.