Sadaf Amin, PhD

Assistant Professor, Pathology and Immunology

Education

BS: Tehran University

MS: Tehran University

PhD: Weill Cornell Medicine

Recognition

NIH K99/R00 Awardee, NIA 2023

Jumpstart Career Development Award, Weill Cornell Medicine 2022-2023

Alzheimer’s Disease Research postdoctoral fellowship, BrightFocus Foundation 2020-2022

Research Interests

Our research investigates the role of the innate immune system in the pathogenesis of neurodegenerative diseases and the processes of brain aging, employing stem cell–based platforms and transgenic mouse models to study mechanisms of neuroimmune interactions in the brain.

Selected Publications

A single-cell, long-read, isoform-resolved case–control study of frontotemporal dementia reveals cell-type specific and broad splicing dysregulation in post-mortem human brain.

Publication

Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.

Publication

Autophagy prevents microglial senescence.

Publication

Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.

Publication

Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy.

Publication

New insights and therapeutic opportunities for progranulin-deficient frontotemporal dementia.

Publication

Assistant

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Administrative Professional