
Richard J. Perrin, MD, PhD
Professor, Pathology & Immunology
Contact
- Email: rperrin@wustl.edu
- Phone: 314-362-7426
Education
BS: Yale College, New Haven, CT (1992)
PhD: University of Illinois Urbana-Champaign, Champaign, IL (2001)
Medical Degree: University of Illinois – Chicago, Chicago, IL (2004)
Anatomic Pathology Residency: Washington University School of Medicine, St. Louis, MO (2006)
Neuropathology Fellowship: Washington University School of Medicine, St. Louis, MO (2008)
Boards
Neuropathology: Board Certified
Anatomic Pathology: Board Certified
Recognition
Castle Connolly Top Doctor (2024-2026)
Alpha Omega Alpha Medical Honor Society, 2003
Robert Terry Award, American Association of Neuropathologists, 2013
Affiliations
Research Interests
Translational Human Neurodegenerative Disease Research to Advance Diagnostics, Understanding, and Treatments
I direct the Translational Human Neurodegenerative Disease Research (THuNDR) Laboratory, which serves as the Neuropathology Core of the Charles F. and Joanne Knight Alzheimer Disease Research Center, the Dominantly Inherited Alzheimer Network, the Dominantly Inherited Alzheimer Network – Trials Unit, the Alzheimer Disease Neuroimaging Initiative, and the Washington University Movement Disorders Center. In this role, I perform neuropathologic evaluations of research participant brain donations and support collaborative translational research projects with investigators domestic and international, with a focus on understanding and developing biomarkers and treatments for neurodegenerative diseases.
Selected Publications
Divergent white matter metabolic signature patterns indicate impending cognitive decline in aging and dementia
Publication
Early syndecan-4 upregulation predicts cognitive and pathological trajectories in Alzheimer disease
Publication
Circulating lipids are related to longitudinal changes of ATN biomarkers for Alzheimer’s disease
Publication
Author Correction: A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting (Nature Neuroscience, (2025), 28, 7, (1436-1445), 10.1038/s41593-025-01977-4)
Publication
Assistant
