Richard J. Perrin, MD, PhD

Richard J. Perrin, MD, PhD

Associate Professor, Pathology & Immunology

Division

  • Neuropathology

Related Link

Education

  • BS: Yale College, New Haven, CT (1992)
  • PhD: University of Illinois Urbana-Champaign, Champaign, IL (2001)
  • Medical Degree: University of Illinois – Chicago, Chicago, IL (2004)
  • Anatomic Pathology Residency: Washington University School of Medicine, St. Louis, MO (2006)
  • Neuropathology Fellowship: Washington University School of Medicine, St. Louis, MO (2008)

Board Certifications

  • Neuropathology: Board Certified
  • Anatomic Pathology: Board Certified

Recognition

  • Robert Terry Award, American Association of Neuropathologists, 2013
  • Alpha Omega Alpha Medical Honor Society, 2003

Clinical Interest

  • Neuropathology

Research Interests

Translational Human Neurodegenerative Disease Research to Advance Diagnostics, Understanding, and Treatments

I direct the Translational Human Neurodegenerative Disease Research (THuNDR) Laboratory, which serves as the Neuropathology Core of the Charles F. and Joann Knight Alzheimer Disease Research Center, the Dominantly Inherited Alzheimer Network, the Dominantly Inherited Alzheimer Network – Trials Unit, the Alzheimer Disease Neuroimaging Initiative, and the Washington University Movement Disorders Center. In this role, I perform neuropathologic evaluations of research participant brain donations and support collaborative translational research projects with investigators domestic and international, with a focus on understanding and developing biomarkers and treatments for neurodegenerative diseases.

Selected Publications

PubMed Search
Genetic architecture of cerebrospinal fluid and brain metabolite levels and the genetic colocalization of metabolites with human traits. 
Wang C, Yang C, Western D, Ali M, Wang Y, Phuah CL, Budde J, Wang L, Gorijala P, Timsina J, Ruiz A, Pastor P, Fernandez MV; Dominantly Inherited Alzheimer Network (DIAN); Alzheimer’s Disease Neuroimaging Initiative (ADNI); Panyard DJ, Engelman CD, Deming Y, Boada M, Cano A, Garcia-Gonzalez P, Graff-Radford NR, Mori H, Lee JH, Perrin RJ, Ibanez L, Sung YJ, Cruchaga C.
Nat Genet. 2024 Dec;56(12):2685-2695. doi: 10.1038/s41588-024-01973-7. Epub 2024 Nov 11.
PMID: 39528826
The Alzheimer’s Disease Neuroimaging Initiative Neuropathology Core: An update. 
Perrin RJ, Franklin EE, Bernhardt H, Burns A, Schwetye KE, Cairns NJ, Baxter M, Weiner MW, Morris JC; Alzheimer’s Disease Neuroimaging Initiative.
Alzheimers Dement. 2024 Nov;20(11):7859-7870. doi: 10.1002/alz.14253. Epub 2024 Oct 1.
PMID: 39351959 Free PMC article.
CSF proteomics identifies early changes in autosomal dominant Alzheimer’s disease. 
Shen Y, Timsina J, Heo G, Beric A, Ali M, Wang C, Yang C, Wang Y, Western D, Liu M, Gorijala P, Budde J, Do A, Liu H, Gordon B, Llibre-Guerra JJ, Joseph-Mathurin N, Perrin RJ, Maschi D, Wyss-Coray T, Pastor P, Renton AE, Surace EI, Johnson ECB, Levey AI, Alvarez I, Levin J, Ringman JM, Allegri RF, Seyfried N, Day GS, Wu Q, Fernández MV, Tarawneh R, McDade E, Morris JC, Bateman RJ, Goate A; Dominantly Inherited Alzheimer Network; Ibanez L, Sung YJ, Cruchaga C.
Cell. 2024 Oct 31;187(22):6309-6326.e15. doi: 10.1016/j.cell.2024.08.049. Epub 2024 Sep 26.
PMID: 39332414 Free PMC article.
A cross-sectional study of α-synuclein seed amplification assay in Alzheimer’s disease neuroimaging initiative: Prevalence and associations with Alzheimer’s disease biomarkers and cognitive function. 
Tosun D, Hausle Z, Iwaki H, Thropp P, Lamoureux J, Lee EB, MacLeod K, McEvoy S, Nalls M, Perrin RJ, Saykin AJ, Shaw LM, Singleton AB, Lebovitz R, Weiner MW, Blauwendraat C; Alzheimer’s Disease Neuroimaging Initiative.
Alzheimers Dement. 2024 Aug;20(8):5114-5131. doi: 10.1002/alz.13858. Epub 2024 May 21.
PMID: 38770829 Free PMC article.
α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer’s disease late in the disease course and dependent on Lewy pathology burden. 
Levin J, Baiardi S, Quadalti C, Rossi M, Mammana A, Vöglein J, Bernhardt A, Perrin RJ, Jucker M, Preische O, Hofmann A, Höglinger GU, Cairns NJ, Franklin EE, Chrem P, Cruchaga C, Berman SB, Chhatwal JP, Daniels A, Day GS, Ryan NS, Goate AM, Gordon BA, Huey ED, Ibanez L, Karch CM, Lee JH, Llibre-Guerra J, Lopera F, Masters CL, Morris JC, Noble JM, Renton AE, Roh JH, Frosch MP, Keene CD, McLean C, Sanchez-Valle R, Schofield PR, Supnet-Bell C, Xiong C, Giese A, Hansson O, Bateman RJ, McDade E; Dominantly Inherited Alzheimer Network; Parchi P.
Alzheimers Dement. 2024 Jun;20(6):4351-4365. doi: 10.1002/alz.13818. Epub 2024 Apr 26.
PMID: 38666355 Free PMC article.
Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue. 
Dhavale DD, Barclay AM, Borcik CG, Basore K, Berthold DA, Gordon IR, Liu J, Milchberg MH, O’Shea JY, Rau MJ, Smith Z, Sen S, Summers B, Smith J, Warmuth OA, Perrin RJ, Perlmutter JS, Chen Q, Fitzpatrick JAJ, Schwieters CD, Tajkhorshid E, Rienstra CM, Kotzbauer PT.
Nat Commun. 2024 Mar 29;15(1):2750. doi: 10.1038/s41467-024-46832-5.
PMID: 38553463 Free PMC article.
Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease. 
Johnson ECB, Bian S, Haque RU, Carter EK, Watson CM, Gordon BA, Ping L, Duong DM, Epstein MP, McDade E, Barthélemy NR, Karch CM, Xiong C, Cruchaga C, Perrin RJ, Wingo AP, Wingo TS, Chhatwal JP, Day GS, Noble JM, Berman SB, Martins R, Graff-Radford NR, Schofield PR, Ikeuchi T, Mori H, Levin J, Farlow M, Lah JJ, Haass C, Jucker M, Morris JC, Benzinger TLS, Roberts BR, Bateman RJ, Fagan AM, Seyfried NT, Levey AI; Dominantly Inherited Alzheimer Network.
Nat Med. 2023 Aug;29(8):1979-1988. doi: 10.1038/s41591-023-02476-4. Epub 2023 Aug 7.
PMID: 37550416 Free PMC article.
Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer’s disease. 
Sung YJ, Yang C, Norton J, Johnson M, Fagan A, Bateman RJ, Perrin RJ, Morris JC, Farlow MR, Chhatwal JP, Schofield PR, Chui H, Wang F, Novotny B, Eteleeb A, Karch C, Schindler SE, Rhinn H, Johnson ECB, Oh HS, Rutledge JE, Dammer EB, Seyfried NT, Wyss-Coray T, Harari O, Cruchaga C.
Sci Transl Med. 2023 Jul 5;15(703):eabq5923. doi: 10.1126/scitranslmed.abq5923. Epub 2023 Jul 5.
PMID: 37406134 Free PMC article.
Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid. 
Drieu A, Du S, Storck SE, Rustenhoven J, Papadopoulos Z, Dykstra T, Zhong F, Kim K, Blackburn S, Mamuladze T, Harari O, Karch CM, Bateman RJ, Perrin R, Farlow M, Chhatwal J; Dominantly Inherited Alzheimer Network; Hu S, Randolph GJ, Smirnov I, Kipnis J.
Nature. 2022 Nov;611(7936):585-593. doi: 10.1038/s41586-022-05397-3. Epub 2022 Nov 9.
PMID: 36352225 Free PMC article.
CSF tau microtubule-binding region identifies pathological changes in primary tauopathies. 
Horie K, Barthélemy NR, Spina S, VandeVrede L, He Y, Paterson RW, Wright BA, Day GS, Davis AA, Karch CM, Seeley WW, Perrin RJ, Koppisetti RK, Shaikh F, Lago AL, Heuer HW, Ghoshal N, Gabelle A, Miller BL, Boxer AL, Bateman RJ, Sato C.
Nat Med. 2022 Dec;28(12):2547-2554. doi: 10.1038/s41591-022-02075-9. Epub 2022 Nov 24.
PMID: 36424467 Free PMC article.
Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy. 
Da Mesquita S, Papadopoulos Z, Dykstra T, Brase L, Farias FG, Wall M, Jiang H, Kodira CD, de Lima KA, Herz J, Louveau A, Goldman DH, Salvador AF, Onengut-Gumuscu S, Farber E, Dabhi N, Kennedy T, Milam MG, Baker W, Smirnov I, Rich SS; Dominantly Inherited Alzheimer Network; Benitez BA, Karch CM, Perrin RJ, Farlow M, Chhatwal JP, Holtzman DM, Cruchaga C, Harari O, Kipnis J.
Nature. 2021 May;593(7858):255-260. doi: 10.1038/s41586-021-03489-0. Epub 2021 Apr 28.
PMID: 33911285 Free PMC article.
Multimodal techniques for diagnosis and prognosis of Alzheimer’s disease. 
Perrin RJ, Fagan AM, Holtzman DM.
Nature. 2009 Oct 15;461(7266):916-22. doi: 10.1038/nature08538.
PMID: 19829371 Free PMC article. Review.

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