Pavel Zakharov, PhD

Instructor, Pathology & Immunology

Education

  • MS: Biophysics, Lomonosov Moscow State University, School of Physics, Moscow, Russia (2010)
  • PhD: Biophysics, Lomonosov Moscow State University, School of Physics, Moscow, Russia (2016)

Twitter Handle

  • @PavelZa35400671

Research Interests

  • Autoimmune diabetes
  • Systems biology
  • Bioinformatics

Publications

Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes PN Zakharov, H Hu, X Wan, ER Unanue. Journal of Experimental Medicine 217 (6), 2020
Cytocidal macrophages in symbiosis with CD4 and CD8 T cells cause acute diabetes following checkpoint blockade of PD-1 in NOD mice. H Hu, PN Zakharov, OJ Peterson, ER Unanue. Proceedings of the National Academy of Sciences, 2020
Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides Xiaoxiao Wan, Bernd H Zinselmeyer, Pavel N Zakharov, Anthony N Vomund, Ruth Taniguchi, Laura Santambrogio, Mark S Anderson, Cheryl F Lichti, Emil R Unanue. Nature 560 (7716), 107-111, 2018
The islet-resident macrophage is in an inflammatory state and senses microbial products in blood. ST Ferris, PN Zakharov, X Wan, B Calderon, MN Artyomov, ER Unanue, JA Carrero. Journal of Experimental Medicine 214 (8), 2369-2385, 2017. *Equal contribution
Molecular and mechanical causes of microtubule catastrophe and aging. P Zakharov, N Gudimchuk, V Voevodin, A Tikhonravov, F Ataullakhanov, E Grishchuk. Biophysical journal 109 (12), 2574-2591, 2015