Nicholas Borcherding, MD, PhD

Division

• Laboratory and Genomic Medicine

Additional Titles

• Fellow, Histocompatibility and Immunogenetics

Education

• BS, Nutritional Sciences: Iowa State University (2012)
• MS, Pathology: University of Iowa (2014)
• PhD, Cancer Biology: University of Iowa (2020)
• MD: University of Iowa (2020)
• Clinical Pathology Residency: Washington University School of Medicine (2023)

Related Links

https://www.borch.dev/

Board Certifications

• Clinical Pathology

Recognition & Awards

• Emerging Generation Award, The American Society for Clinical Investigation (2022)
• Paul E. Strandjord Young Investigator Award, Academy of Laboratory Physicians and Scientists (2022)
• Williams L. Roberts Young Investigator Award with Distinction, Academy of Laboratory Physicians and Scientists (2021)
• Special Achievement in Pathology, Iowa Pathology Society (2020)
• Hancher-Finkbine Medallion, University of Iowa (2019)

Clinical Interests

• Human leukocyte antigen
• T and B cell receptor sequencing
• Immunology-based diagnostic testing
• Computational approaches for diagnostics

Research Interests

The adaptive immune system is a central node in the molecular pathogenesis across all diseases. Encoded within our genome is the ability to respond to the vast array of pathogens and, if improperly regulated, ourselves. My research has focused on developing computational approaches to distilling and deciphering adaptive immune receptor sequences and tracking immune cell interaction through intracellular mitochondria transfer.

Selected Publications

Irac, S., Soon, M., Borcherding, N., & Tuong, Z.K. (2024) Single-cell immune repertoire analysis. Nature Methods. PMID: 38637691.

Borcherding, N. & Brestoff, J. (2023). The Power and Potential of Mitochondria Transfer. Nature. PMID: 3798702.

Borcherding, N., Jia, W., Giwa, R., Field, R.L., Moley, J.R., Kopecky, B., Chan M., Yang, B., Sabio, J., Walker E., Osorio, O., Bredemeyer, A., Pietka, T., Alexander-Brett, J., Morley S.C., Artyomov, M., Abumrad, N., Schilling, J., Lavine, K., Crewe, C., & Brestoff, J.R. (2022) Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood. Cell Metabolism. PMID: 36070756.

Borcherding, N., Vishwakarma, A., Voigt, A.P., Nepple, K., Salem, A., Jenkins, R.W., Zhang, W., Zakharia, Y. (2021) Mapping the immune environment in clear cell renal carcinoma by single-cell genomics. Communications Biology. PMID: 33504936.

Borcherding, N.,* Bormann, N., & Kraus, G. (2020). scRepertoire: A R-based toolkit for single-cell immune receptor analysis. F1000Research. PMID: 32789006.

Assistant:
Shelley Cuervo
314-362-2207
cuervo@wustl.edu
IOH Room 5800