Maxim N. Artyomov, PhD

Associate Professor, Pathology & Immunology

Email: martyomov@wustl.edu

Additional Titles

Adjunct Professor, ITMO University, St. Petersburg, Russia

Education

BS, with honors: Moscow State University, Moscow, Russia (2004)
MS, University of Chicago, Chicago, IL (2005)
PhD, Massachusetts Institute of Technology, Cambridge, MA (2009)

Research Interests

We aim to discover novel fundamental biology in the areas of Immunometabolism, Cancer Immunology and Aging by using cross-disciplinary approaches to data generation and analysis together with in vitro and in vivo experimental biology.

In our laboratory, classically trained immunologists and molecular biologists work hand-in-hand with computational biologists and computer scientists to leverage the power of high-throughput omics datasets. Collectively, our approach can be characterized as Systems Immunology.

DBBS Graduate Program Affiliation

Immunology Program
Computational and Systems Biology Program
Computational and Molecular Biophysics Program

Publications

PubMed Search

Artyomov MN, Van den Bossche J. Immunometabolism in the Single-Cell Era. Cell Metab. 2020 Nov 3;32(5):710-725. doi: 10.1016/j.cmet.2020.09.013. Epub 2020 Oct 6. PMID: 33027638; PMCID: PMC7660984. https://pubmed.ncbi.nlm.nih.gov/33027638/

Mogilenko DA, Shpynov O, Andhey PS, Arthur L, Swain A, Esaulova E, Brioschi S, Shchukina I, Kerndl M, Bambouskova M, Yao Z, Laha A, Zaitsev K, Burdess S, Gillfilan S, Stewart SA, Colonna M, Artyomov MN. Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK⁺ CD8⁺ T Cells as Conserved Hallmark of Inflammaging. Immunity. 2021 Jan 12;54(1):99-115.e12. doi: 10.1016/j.immuni.2020.11.005. Epub 2020 Dec 2. PMID: 33271118. https://pubmed.ncbi.nlm.nih.gov/33271118/

Mogilenko DA, Shchukina I, Artyomov MN. Immune ageing at single-cell resolution. Nat Rev Immunol. 2021 Nov 23:1–15. doi: 10.1038/s41577-021-00646-4. Epub ahead of print. PMID: 34815556; PMCID: PMC8609266. https://pubmed.ncbi.nlm.nih.gov/34815556/

Itaconate: the poster child of metabolic reprogramming in macrophage function. O’Neill LAJ1, Artyomov MN2. Nat Rev Immunology, 2019

MHC-II neoantigens shape tumour immunity and response to immunotherapy. Alspach E, Lussier DM, Miceli AP, Kizhvatov I, DuPage M, Luoma AM, Meng W, Lichti CF, Esaulova E, Vomund AN, Runci D, Ward JP, Gubin MM, Medrano RFV, Arthur CD, White JM, Sheehan KCF, Chen A, Wucherpfennig KW, Jacks T, Unanue ER, Artyomov MN, Schreiber RD. Nature. 2019

Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis. Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, Korenfeld D, Mathyer ME, Kim H, Huang LH, Duncan D, Bregman H, Keskin A, Santeford A, Apte RS, Sehgal R, Johnson B, Amarasinghe GK, Soares MP, Satoh T, Akira S, Hai T, de Guzman Strong C, Auclair K, Roddy TP, Biller SA, Jovanovic M, Klechevsky E, Stewart KM, Randolph GJ, Artyomov MN. Nature. 2018 Apr 18.

High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy. Gubin MM, Esaulova E, Ward JP, Malkova ON, Runci D, Wong P, Noguchi T, Arthur CD, Meng W, Alspach E, Medrano RFV, Fronick C, Fehlings M, Newell EW, Fulton RS, Sheehan KCF, Oh ST, Schreiber RD, Artyomov MN. Cell 2018

Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. Lampropoulou V, Sergushichev A, Bambouskova M, Nair S, Vincent EE, Loginicheva E, Cervantes-Barragan L, Ma X, Huang SC, Griss T, Weinheimer CJ, Khader S, Randolph GJ, Pearce EJ, Jones RG, Diwan A, Diamond MS, Artyomov MN. Cell Metab. 2016 Jul 12;24(1):158-66

Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. Jha AK, Huang SC, Sergushichev A, Lampropoulou V, Ivanova Y, Loginicheva E, Chmielewski K, Stewart KM, Ashall J, Everts B, Pearce EJ, Driggers EM, Artyomov MN. Immunity. 2015 Mar 17;42(3):419-30.

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Gubin MM, Zhang X, Schuster H, Caron E, Ward JP, Noguchi T, Ivanova Y, Hundal J, Arthur CD, Krebber WJ, Mulder GE, Toebes M, Vesely MD, Lam SS, Korman AJ, Allison JP, Freeman GJ, Sharpe AH, Pearce EL, Schumacher TN, Aebersold R, Rammensee HG, Melief CJ, Mardis ER, Gillanders WE, Artyomov MN, Schreiber RD. Nature. 2014 Nov 27;515(7528):577-81.