Mark A. Zaydman, MD, PhD

Assistant Professor, Pathology & Immunology

 

Education

  • BSE, Biomedical Engineering (Summa Cum Laude): Case Western Reserve University, Cleveland, Ohio (2007)
  • MD, Washington University School of Medicine, St. Louis, Missouri (2016)
  • PhD, Biomedical Engineering: Washington University in St. Louis, St. Louis, MO (2016)
  • Residency, Clinical Pathology: Barnes Jewish Hospital (2019)

Subspecialization

  • Clinical Pathology

Recognition

  • Presidential Scholarship Award, Case Western Reserve University (2003-2007)
  • Alumni Association Scholarship Award, Case Western Reserve University (2004-2007)
  • Deans Honor List, Case Western Reserve University (2003-2006)
  • Outstanding Sophomore Award, Case School of Engineering, Case Western Reserve University (2005)
  • Outstanding Junior Award, Case School of Engineering, Case Western Reserve University (2006)
  • Undergraduate Research Fellowship, American Heart Association (2006)
  • Chairman Award, Department of Biomedical Engineering, Case Western Reserve University (2007)
  • Best Talk Award, Medical Scientist Training Program, Annual Retreat, Washington University in St. Louis (2011)
  • Predoctoral Research Fellowship, American Heart Association (2011)
  • Best Poster Award, Department of Biochemistry and Biophysics, Annual Retreat, Washington University in St. Louis (2013)
  • T32 Appointment, NIH Training Grant, Washington University in St. Louis (2013-2014) Best Poster Award (Predoctoral Category), School of Medicine, Cardiovascular Research Day, Washington University in St. Louis (2013)
  • Spencer T. and Ann W. Olin Fellowship, “For past achievement and the promise of a distinguished career in the biomedical sciences”, Medical Scientist Training Program, Washington University in St. Louis (2015)
  • Best Trainee Oral Presentation Award, Division of Lab and Genomic Medicine, Grand Rounds, Washington University in St. Louis (2017)
  • Paul. E. Strandjord Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists (2017, 2019, 2020)
  • Distinguished Abstract Award, American Association for Clinical Chemistry, Annual Meeting (2019)
  • William Roberts Young Investigator Award with Distinction, Academy of Clinical Laboratory Physicians and Scientists (2021)

Clinical Interests

  • Clinical informatics
  • Clinical decision support
  • Analytics Laboratory test utilization

Research Interests

  • Quantitative systems modeling
  • Bioinformatics
  • Emergent functions of biological systems
  • Multiscale modeling of complex system behavior

Publications

Li Y, Zaydman MA, Wu D, et al. KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity. Proc Natl Acad Sci U S A. 2011;108(22):9095‐9100. doi:10.1073/pnas.1100872108
Zaydman MA, Silva JR, Delaloye K, et al. Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening. Proc Natl Acad Sci U S A. 2013;110(32):13180‐13185. doi:10.1073/pnas.1305167110
Zaydman MA, Kasimova MA, McFarland K, et al. Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel. Elife. 2014;3:e03606. Published 2014 Dec 23. doi:10.7554/eLife.03606
Kasimova MA, Zaydman MA, Cui J, Tarek M. PIP₂-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6. Sci Rep. 2015;5:7474. Published 2015 Jan 6. doi:10.1038/srep07474
Brestoff JR, Zaydman MA, Scott MG, Gronowski AN. “Diagnosis of red meat allergy with antigen-specific IgE tests in serum” Journal of Allergy and Clinical Immunology. Aug 2017; Vol 140(2) 608-610. doi: 10.1016/j.jaci.2017.01.032
Brestoff JR, Tesfazghi MT, Zaydman MA, Jackups R, Kim BS, Scott MG, Gronowski AN, Grossman BJ. “The B antigen protects against the development of red meat allergy” The Journal of Allergy and Clinical Immunology: In Practice. Sep 2018; Vol 6(5) 1790-1791. doi: 10.1016/j.jaip.2018.02.010
Zaydman MA, Brestoff JR, Gronowski AM. “Kinetic Approach Extends the Analytical Measurement Range and Corrects Antigen Excess in Homogeneous Turbidimetric Immunoassays” The Journal of Applied Laboratory Medicine, Volume 4, Issue 2, 1 September 2019, Pages 214–223. doi: 10.1373/jalm.2019.029256
Hou P, Kang PW, Kongmeneck AD, Yang N-D, Liu Y, Shi J, Xu X, White KMF, Zaydman MA, Kasimova MA, Seebohm G, Zhong L, Zou X, Tarek M, Cui J. Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation. Nat Commun 11, 676 (2020). doi: 10.1038/s41467-020-14406-w
Bramley JC, Yenkin AL, Zaydman MA, DiAntonio A, Milbrandt JD, Buchser WJ. Domain-centric database to uncover structure of minimally characterized viral genomes. Sci Data 7, 202 (2020). doi: 10.1038/s41597-020-0536-1
Zaydman MA, Brestoff JR, and Jackups R. Using information theory to optimize a diagnostic threshold to match physician-ordering practice. Journal of Biomedical Informatics 117 103756 doi: https://doi.org/10.1016/j.jbi.2021.103756

Assistant
Julie Shafferkoetter
+1 (314) 362-3186
shafferkoetterj@wustl.edu