Kilannin Krysiak, PhD

Division

• Genomic & Molecular Pathology

Additional Titles

• Associate Medical Director, Cytogenomics and Molecular Pathology Laboratory

Education

• BS: Molecular and Cellular Biology – University of Illinois Urbana-Champaign (2006)
• PhD: Molecular Genetics and Genomics – Washington University in Saint Louis (2014)
• Fellowship: Laboratory Genetics and Genomics – Washington University School of Medicine (2020)

Recognition

• Cancer Genomics Consortium Annual Meeting, featured presentation, 2019
• Melbourne Genomics Health Alliance Expert in Residence, 2019
• Internationa Society of Biocuration Microgrant, 2018
• 10th International Biocuration Conference, poster award, 2017
• NCI/NIH Ruth L. Kirschstein National Research Service Award, 2012
• Special Emphasis Pathway in Cancer Biology Predoctoral Fellowship, 2009

Clinical Interests

• Clinical Genetics and Genomics
• Cytogenetics
• Clinical Informatics

Board Certifications

• American Board of Medical Genetics and Genomics, Diplomate in Laboratory Genetics and Genomics

Research Interests

Dr. Krysiak’s research interests focus on making genetic testing more accessible and clinically useful. She is involved in the development and improvement of both the accessibility of and standards for cancer variant interpretations. Another part of her work focuses on the genomics of hematologic malignancies, particularly B-cell lymphomas.

Selected Publications

K. Krysiak, JF. Tibbitts, J. Shao, T. Liu, M. Ndonwi, MJ. Walter. “Reduced levels of Hspa9 attenuate Stat5 activation in mouse B cells.” Exp Hematol. 2015 Apr;43(4):319-30.

K. Krysiak, F. Gomez, BS. White, M. Matlock, CA. Miller, L. Trani, CC. Fronick, RS. Fulton, F. Kreisel, AF. Cashen, KR. Carson, MM. Berrien-Elliott, NL. Bartlett, M. Griffith, OL. Griffith and TA. Fehniger. “Recurrent Somatic Mutations Affecting B-Cell Receptor Signaling Pathway Genes in Follicular Lymphoma.” Blood. 2017 Jan 26;129(4):473-483.

M. Griffith*, NC. Spies*, K. Krysiak*, JF. McMichael, AC. Coffman, AM. Danos, BJ. Ainscough, CA. Ramirez, DT. Rieke, L. Kujan, EK. Barnell, AH. Wagner, ZL. Skidmore, A. Wollam, CJ. Liu, MR. Jones, RL. Bilski, R. Lesurf, YY. Feng, NM. Shah, M. Bonakdar, L. Trani, M. Matlock, A. Ramu, KM. Campbell, GC. Spies, AP. Graubert, K. Gangavarapu, JM. Eldred, DE. Larson, JR. Walker, BM. Good, C. Wu, AI. Su, R. Dienstmann, A. Margolin, D. Tamborero, N. Lopez-Bigas, SJM. Jones, R. Bose, DH. Spencer, LD. Wartman, RK. Wilson, ER. Mardis, OL. Griffith. “CIViC: A knowledgebase for expert-crowdsourcing the clinical interpretation of variants in cancer.” Nat Gen. 2017 Jan 31;49(2):170-174. *these authors contributed equally to this work

AH. Wagner, B. Walsh, G. Mayfield, D. Tamborero, D. Sonkin, K. Krysiak, J. Pons, RP. Duren, J. Gao, J. McMurry, S. Patterson, C. Del Vecchio Fitz, BA. Pitel, OU. Sezerman, K. Ellrott, JL. Warner, DT. Rieke, T. Aittokallio, E. Cerami, D. Ritter, LM. Schriml, RR. Freimuth, M. Haendel, G. Raca, S. Madhavan, M. Baudis, JS. Beckmann, R. Dienstmann, D. Chakravarty, XS. Li, S. Mockus, O. Elemento, N. Schultz, N. Lopez-Bigas, M. Lawler, J. Goecks, M. Griffith, OL. Griffith, AA. Margolin; Variant Interpretation for Cancer Consortium. “A harmonized meta-knowledgebase of somatic clinical interpretations of cancer genomic variants.” Nat. Gen. 2020 Apr;52(4):448-457.

K. Uguen*, K. Krysiak*, S. Audebert-Bellanger, S. Redon, C. Benech, E. Viora-Dupont, F. Tran Mau-Them, S. Rondeau, I. Elsharkawi, JL. Granadillo, J. Neidich, C. Azevedo Soares, N. Tkachenko, SM. Amudhavalli, K. Engleman, A. Boland, JF. Deleuze, S. Bezieau, S. Odent, A. Toutain, D. Bonneau, B. Gilbert-Dussardier, L. Faivre, M. RIO, C. Le Marechal, C. Ferec, E. Repnikova, Y. Cao. “Heterozygous HMGB1 loss-of-function variants are associated with developmental delay and microcephaly.” Clinical Genetics. 2021. Oct;100(4):386-395. *these authors contributed equally to this work

P. Horak, M. Griffith, A. Danos, BA. Pitel, S. Madhavan, X. Liu, C. Chow, H. Williams, L. Carmody, L. Barrow-Laing, D. Rieke, S. Kreutzfeldt, A. Stenzinger, D. Tamborero, M. Benary, PS. Rajagopal, CM. Ida, H. Lesmana, L. Satgunaseelan, JD. Merker, M. Tolstorukov, PV. Campregher, JL. Warner, S. Rao, M. Natesan, H. Shen, J. Venstrom, S. Roy, K. Tao, R. Kanagal, X. Xu, DI. Ritter, K. Pagel, K. Krysiak, A. Dubuc, YM. Akkari, XS. Li, J. Lee, I. King, G. Raca, AH. Wagner, MM. Li, SE. Plon, S. Kulkarni, OL. Griffith, D. Chakravarty, D. Sonkin. “Standards for the Classification of Pathogenicity of Somatic Variants in Cancer (Oncogenicity): Joint Recommendations of Clinical Genome Resource (ClinGen) and Cancer Genomics Consortium (CGC).” Genet in Med. 2022 May;24(5):986-998.

A. Chiorean, K. Farncombe, S. Delong, V. Andric, S. Ansar, C. Chan, K. Clark, A. Danos, Y. Gao, R. Giles, A. Goldengerg, P. Jani, K. Krysiak, L. Kujan, S. Macpherson, E. Maher, L. McCoy, Y. Salama, J. Saliba, L. Sheta, M. Griffith, OL. Griffith, L. Erdman, A. Ramani. “Large scale genotype- and phenotype-driven machine learning in Von Hippel-Lindau disease.” Hum Mutat. 2022 Sep;43(9):1268-1285.

K. Krysiak*, AM. Danos*, S. Kiwala, JF. McMichael, AC. Coffman, EK. Barnell, L. Sheta, J. Saliba, CJ. Grisdale, L. Kujan, S. Pema, J. Lever, NC. Spies, A. Chiorean, DT. Rieke, KA. Clark, P. Jani, H. Takahashi, P. Horak, DI. Ritter, X. Zhou, BJ. Ainscough, S. Delong, M. Lamping, AR. Marr, BV. Li, WH. Lin, P. Terraf, Y. Salama, K. Campbell, KM. Farncombe, J. Ji, X. Zhao, X. Xu, R. Kanagal-Shamanna, KC. Cotto, ZL. Skidmore, JR. Walker, J. Zhang, A. Milosavljevic, RY. Patel, RH. Giles, RH. Kim, LM. Schriml, ER. Mardis, SJM. Jones, G. Raca, S. Rao, S. Madhavan, AH. Wagner, OL. Griffith, M. Griffith. “A community approach to the cancer-variant-interpretation bottleneck.” Nat Cancer. 2022 May;3(5):522-525. *these authors contributed equally to this work

K. Krysiak*, AM. Danos, J. Saliba, JF. McMichael, AC. Coffman, S. Kiwala, EK. Barnell, L. Sheta, CJ. Grisdale, L. Kujan, S. Pema, J. Lever, S. Ridd, NC. Spies, V. Andric, A. Chiorean, DT. Rieke, KA. Clark, C. Reisle, AC. Venigalla, M. Evans, P. Jani, H. Takahashi, A. Suda, P. Horak, DI. Ritter, X. Zhou, BJ. Ainscough, S. Delong, C. Kesserwan, M. Lamping, H. Shen, AR. Marr, MH Hoang, K. Singhal, M. Khanfar, BV. Li, WH. Lin, P. Terraf, LB. Corson, Y. Salama, KM. Campbell, KM. Farncombe, J. Ji, X. Zhao, X. Xu, R. Kanagal-Shamanna, I. King, KC. Cotto, ZL. Skidmore, JR. Walker, J. Zhang, A. Milosavljevic, RY. Patel, RH. Giles, RH. Kim, LM. Schriml, ER. Mardis, SJM. Jones, G. Raca, S. Rao, S. Madhavan, AH. Wagner, M. Griffith, OL. Griffith. “CIViCdb 2022: evolution of an open-access cancer variant interpretation knowledgebase.” Nucleic Acids Res. 2023 Jan 6;51(D1):D1230-D1241. *these authors contributed equally to this work

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Assistant:
Dani Salazar
314-362-2975
sdaniela@wustl.edu