Jacqueline Payton, MD, PhD

Research Interests

The overarching goal of my research program is to elucidate regulatory mechanisms in the immune system, with a focus on infection and malignancy. The foundation of our work is the discovery of novel pathogenic gene regulatory processes, which we experimentally test using molecular, cellular, and animal models to dissect underlying mechanisms and identify potential therapeutic strategies. Throughout these studies, we apply cutting edge multi-omics approaches and develop innovative bioinformatic tools to reveal novel gene regulatory processes^1-4. As a molecular pathologist, I develop and optimize clinical molecular assays for precision medicine approaches to diagnosis and disease monitoring. My translational and clinical research thus incorporates diverse approaches from molecular pathology, informatics, immunology, and systems biology.

DBBS Affiliation

• Biomedical Informatics and Data Science

• Cancer Biology

• Molecular Genetics and Genomics

• Molecular Microbiology and Microbial Pathogenesis