Igor Smirnov, DVM

Division

• Immunobiology

Education

• DVM: Moscow State Academy of Veterinary Medicine and Biotechnology, Moscow, Russian Federation (1986-1993)

Research Interests

My main interest is in developing animal models of traumatic and degenerative injuries of the nervous system to assess the role of the immune system during normal brain function, after an injury, and during the course of a neurodegenerative diseases.

Selected Publications

Bolte AC, Hurt ME, Smirnov I, Kovacs MA, McKee CA, Natale N, Ennerfelt HE, Frost EL, Lammert CE, Kipnis J, Lukens JR. “Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis” Nat Commun. 2020, 11(1):4524. doi: 10.1038/s41467-020-18113-4.

Da Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison RC, Kingsmore KM, Contarino C, Onengut-Gumuscu S, Farber, Raper D, Viar KE, Powell RD, Baker W, Dabhi N, Bai R, Cao R, Hu S, Rich S, Munson JM, Lopes MB, Overall CC, Acton ST, Kipnis J. “Functional aspects of meningeal lymphatics in aging and Alzheimer’s disease.”. Nature. 2018, 560(7717):185-191. doi: 10.1038/s41586-018-0368-8.

Louveau A, Herz J, Alme MN, Salvador AF, Dong MQ, Viar KE, Herod SG, Knopp J, Setliff JC, Lupi AL, Da Mesquita S, Frost EL, Gaultier A, Harris TH, Cao R, Hu S, Lukens JR, Smirnov I, Overall CC, Oliver G, Kipnis J. “CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature”. Nat Neurosci. 2018, 21(10):1380-1391. doi: 10.1038/s41593-018-0227-9.

Norris GT, Smirnov I, Filiano AJ, Shadowen HM, Cody KR, Thompson JA, Harris TH, Gaultier A, Overall CC, Kipnis J. “Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury”. J Exp Med. 2018, 215(7):1789-1801. doi: 10.1084/jem.20172244.

Cronk JC, Filiano AJ, Louveau A, Marin I, Marsh R, Ji E, Goldman DH, Smirnov I, Geraci N, Acton S, Overall CC, Kipnis J.” Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia”. J Exp Med. 2018, 215(6):1627-1647. doi: 10.1084/jem.20180247.

Cronk JC, Herz J, Kim TS, Louveau A, Moser EK, Sharma AK, Smirnov I, Tung KS, Braciale TJ, Kipnis J. “Influenza A induces dysfunctional immunity and death in MeCP2-overexpressing mice.” JCI Insight. 2017, 2(2): e88257. doi: 10.1172/jci.insight.88257.