Eric J. Huang, MD, PhD

Eric J. Huang, MD, PhD

Edward Mallinckrodt Professor and Chair, Department of Pathology & Immunology
Pathologist-in-Chief, Barnes-Jewish Hospital

Division

  • Anatomic & Molecular Pathology
  • Neuropathology

Education

  • MD, National Taiwan University (1979-1986)
  • PhD, Weill Cornell Graduate School of Medical Sciences & Sloan-Kettering Institute (1993)
  • Residency, Department of Pathology, University of California San Francisco (1993-1995)
  • Fellowship (Neuropathology), Department of Pathology, University of California San Francisco (1995-1997)
  • Postdoctoral Fellowship, Howard Hughes Medical Institute & University of California San Francisco (1997-2000)

Board Certifications

  • American Board of Pathology (Anatomic Pathology), 1997
  • American Board of Pathology (Neuropathology), 1997

Recognition

  • Frank Lappin Horsfall, Jr. Fellowship (Memorial Sloan-Kettering Cancer Center), 1990-1991
  • Vincent du Vigneaud Award of Excellence (Weill Cornell Graduate School of Medical Sciences), 1991
  • Postdoctoral Research Fellowship for Physicians (Howard Hughes Medical Institute), 1997-2000
  • Weil Award (AANP Annual Meetings), 1998
  • Presidential Early Career Award for Scientists and Engineers (PECASE), 2000-2005
  • Independent Scientist Award (NINDS/NIH), 2002-2007
  • Mid-career Investigator Award in Mouse Pathobiology (NCRR/NIH), 2009-2015
  • Chair, GRC on Molecular & Cellular Neurobiology, 2014
  • The DeArmond Lecture (AANP Annual Meeting), 2016
  • The Stowell Lecture, Dept of Pathology, UC Davis, 2017
  • Keynote Speaker, 27th International Complement Workshop, 2018
  • Mentoring Award, UCSF BMS Graduate Program, 2019
  • Organizer, Keystone Symposium on Neurodegenerative Diseases, 2021
  • Award of Distinction, Weill Cornell Graduate School of Medical Sciences, 2021
  • Academician, Academia Sinica, Taipei, Taiwan, 2024

Clinical Interests

  • Autopsy neuropathology

Research Interests

  • Molecular and cellular mechanisms of neural development and neurodegeneration

Affiliations

  • Division of Biology & Biomedical Sciences

Selected Publications

PubMed Search
Chen J, Crouch EE, Zawadzki ME, Jacobs KA, Mayo LN, Choi JJ, Lin PY, Shaikh S, Tsui J, Gonzalez-Granero S, Waller S, Kelekar A, Kang G, Valenzuela EJ, Birrueta JO, Diafos LN, Wedderburn-Pugh K, Di Marco B, Xia W, Han CZ, Coufal NG, Glass CK, Fancy SPJ, Alfonso J, Kriegstein AR, Oldham MC, Garcia-Verdugo JM, Kutys ML, Lehtinen MK, Combes AJ, Huang EJ. Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain. Nature Neurosci 2024 Sept 30, doi: 10.1038/s41593-024-01769-2, PMID: 39349662.
Marsan E, Velmeshev D, Ramsey A, Patel RK, Zhang J, Koontz M, Andrews MG, de Majo M, Mora C, Blumenfeld J, Li AN, Spina S, Grinberg LT, Seeley W, Miller BL, Ullian EM, Krummel MF, Kriegstein A, Huang EJ. Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations. J Clin Invest. 2023 Mar 15;133(6):e164919. doi: 10.1172/JCI164919. PMID: 36602862; PMCID: PMC10014110.
Crouch EE, Bhaduri A, Andrews MG, Cebrian-Silla A, Diafos LN, Birrueta JO, Wedderburn-Pugh K, Valenzuela EJ, Bennett NK, Eze UC, Sandoval-Espinosa C, Chen J, Mora C, Ross JM, Howard CE, Gonzalez-Granero S, Lozano JF, Vento M, Haeussler M, Paredes MF, Nakamura K, Garcia-Verdugo JM, Alvarez-Buylla A, Kriegstein AR, Huang EJ. Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain. Cell. 2022 Sep 29;185(20):3753-3769.e18. doi: 10.1016/j.cell.2022.09.004. PMCID: PMC9550196.
Paredes MF, Mora C, Flores-Ramirez Q, Cebrian-Silla A, Del Dosso A, Larimer P, Chen J, Kang G, Gonzalez Granero S, Garcia E, Chu J, Delgado R, Cotter JA, Tang V, Spatazza J, Obernier K, Lozano JF, Vento M, Scott J, Studholme C, Nowakowski TJ, Kriegstein AR, Oldham MC, Hasenstaub A, Garcia-Verdugo JM, Alvarez-Buylla A, Huang EJ. Nests of dividing neuroblasts sustain interneuron production for the developing human brain. Science 375, eabk2346, 2022. Doi: 10.1126/science.abk2346. PMCID: PMC8887556.
Zhang J, Velmeshev D, Hashimoto K, Huang HY, Hofmann JW, Shi X, Chen J, Leidal AM, Dishart JG, Cahill MK, Kelley KW, Liddelow SA, Seeley WW, Miller BL, Walther TC, Farese RV, Jr, Taylor JP, Ullian EM, Huang B, Debnath J, Wittmann T, Kriegstein AR, Huang EJ. Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. Nature. 2020 Dec;588(7838):459-465. PMID: 32866962, PMCID: PMC7746606.
Kao AW, McKay A, Singh PP, Brunet A, Huang EJ. Progranulin, lysosomal regulation and neurodegenerative disease. Nature Rev Neurosci. 2017 Jun;18(6):325-333. PMID: 28435163, PMCID: PMC6040832.
Paredes MF, James D, Gil-Perotin S, Kim H, Cotter JA, Ng C, Sandoval K, Rowitch DH, Xu D, McQuillen PS, Garcia-Verdugo JM, Huang EJ, Alvarez-Buylla A. Extensive migration of young neurons into the infant human frontal lobe. Science. 2016 Oct 7;354(6308). pii: aaf7073. PMCID: PMC5436574. (*Co-corresponding author)
Lui H, Zhang J, Makinson SR, Cahill MK, Kelley KW, Huang HY, Shang Y, Oldham MC, Martens LH, Gao FY, Coppola G, Sloan SA, Hsieh CL, Kim CC, Bigio EH, Weintraub S, Mesulam MM, Rademakers R, Mackenzie IR, Seeley WW, Karydas A, Miller BL, Borroni B, Ghidoni R, Farese RV, Paz JT, Barres BA, Huang EJ. Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation. Cell. 2016 May 5;165(4):921-35. PMID: 27114033, PMCID: PMC4860138.

Kevin Shaw

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k.shaw@wustl.edu
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