Eric J. Duncavage, MD

Eric J. Duncavage, MD

Professor, Pathology & Immunology
Division Chief, Genomic and Molecular Pathology

 

Division

  • Genomic & Molecular Pathology

Additional Titles

  • Division chief, Genomic and Molecular Pathology

Education

  • Hematopathology Fellow: University of Utah/ARUP lab, Salt Lake City, UT (2009-2010)
  • Molecular Genetic Pathology Fellow: Washington University, St. Louis, MO (2008-2009)
  • Resident Physician, Anatomic and Clinical Pathology: Washington University/Barnes-Jewish Hospital, St. Louis, MO (2004-2008)
  • Medical Degree: University of Tennessee College of Medicine, Memphis, TN (1999-2004)
  • Cum Laude, Majors in Physics and Chemistry: Vanderbilt University, Nashville, TN (1994-1998)
  • Tennessee Honors Diploma: Brentwood High School, Brentwood, TN (1990-1994)

Board Certifications

  • Board Certified in Anatomic and Clinical Pathology
  • Board Certified in Molecular Pathology
  • Board Certified in Hematopathology
  • Board Certified in Clinical Informatics
  • NY State Certificate of Qualification (Histology and Molecular)

Recognition

  • Harry Hill Departmental Research Grant, University of Utah, 2009
  • College of American Pathologists (CAP) Research Training Grant, 2009
  • Pulmonary Pathology Society Trainee Research Award, USCAP 2009
  • American Medical Association Resident Research Grant, 2008
  • CAP Fall Informatics Meeting (APIII) Travel Grant, 2007
  • CAP Spring Informatics Meeting Travel Grant, 2007
  • University of Tennessee Alumni Achievement Research Award, 2004
  • Howard Hughes Medical Institute Predoctoral Fellowship, 2001
  • NIH Summer Medical Student Research, Fellowship Recipient, 2000
  • Honorable Mention–Tennessee Biomedical Research Fair, 1998

Clinical Interests

  • Hematopathology
  • Molecular Genetic Pathology

Research Interests

Dr. Duncavage is a professor in the Department of Pathology and Immunology at WashU Medicine in St. Louis, MO and is a member of the Siteman Cancer Center. He currently serves as the director of Genomic and  Molecular Pathology Division and is the former director of the hematopathology section.  Dr. Duncavage is board certified in anatomic pathology, clinical pathology, molecular pathology, hematopathology, and clinical informatics.  His clinical practice includes sign out of blood, bone marrow, lymph nodes, and molecular diagnostics cases. As the director of molecular oncology, Dr. Duncavage oversees molecular testing in the regulated CAP/CLIA environment including the design and implementation of cutting-edge assays such as MyeloSeq®-HD, a first to market UMI-based NGS assay for the detection of measurable residual disease in myeloid neoplasms, and ChromoSeq®, a first to market comprehensive WGS-based assay for myeloid neoplasms. Dr. Duncavage’s research is focused on understanding the biology of myeloid neoplasms such as MDS and AML and developing better clinical diagnostics using sequencing-based approaches. This work is funded through several NIH and foundation awards and has resulted in multiple high-profile publications.

Selected Publications

Rosenbaum, Jason N; Bloom, Ryan; Forys, Jason T; Hiken, Jeff; Armstrong, Jon R; Branson, Julie; McNulty, Samantha; Velu, Priya D; Pepin, Kymberlie; Abel, Haley; Genomic heterogeneity of ALK fusion breakpoints in non-small-cell lung cancer. Modern Pathology. Volume 31, 5; pages 791-808, 2018, Nature Publishing Group.
Duncavage, Eric J; Jacoby, Meagan A; Chang, Gue Su; Miller, Christopher A; Edwin, Natasha; Shao, Jin; Elliott, Kevin; Robinson, Joshua; Abel, Haley; Fulton, Robert S; Mutation clearance after transplantation for myelodysplastic syndrome. New England Journal of Medicine. Volume 379, 11; pages 1028-1041, 2018, Massachusetts Medical Society.
Christopher, Matthew J; Petti, Allegra A; Rettig, Michael P; Miller, Christopher A; Chendamarai, Ezhilarasi; Duncavage, Eric J; Klco, Jeffery M; Helton, Nicole M; O’Laughlin, Michelle; Fronick, Catrina C; Immune escape of relapsed AML cells after allogeneic transplantation. New England Journal of Medicine. Volume 379, 24; pages 2330-2341, 2018, Massachusetts Medical Society.
Li, Marilyn M; Datto, Michael; Duncavage, Eric J; Kulkarni, Shashikant; Lindeman, Neal I; Roy, Somak; Tsimberidou, Apostolia M; Vnencak-Jones, Cindy L; Wolff, Daynna J; Younes, Anas; Standards and guidelines for the interpretation and reporting of sequence variants in cancer: a joint consensus recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists. The Journal of Molecular Diagnostics. Volume 19, 1; 2017. Elsevier
Welch, John S; Petti, Allegra A; Miller, Christopher A; Fronick, Catrina C; O’Laughlin, Michelle; Fulton, Robert S; Wilson, Richard K; Baty, Jack D; Duncavage, Eric J; Tandon, Bevan; TP53 and decitabine in acute myeloid leukemia and myelodysplastic syndromes. New England Journal of Medicine. Volume 375, 21; pages 2023-2036, 2016. Massachusetts Medical Society.
Klco, Jeffery M; Miller, Christopher A; Griffith, Malachi; Petti, Allegra; Spencer, David H; Ketkar-Kulkarni, Shamika; Wartman, Lukas D; Christopher, Matthew; Lamprecht, Tamara L; Helton, Nicole M; Association between mutation clearance after induction therapy and outcomes in acute myeloid leukemia. JAMA. Volume 314, 8; pages 811-822, 2015. American Medical Association.
Abel, Haley J; Al-Kateb, Hussam; Cottrell, Catherine E; Bredemeyer, Andrew J; Pritchard, Colin C; Grossmann, Allie H; Wallander, Michelle L; Pfeifer, John D; Lockwood, Christina M; Duncavage, Eric J; Detection of gene rearrangements in targeted clinical next-generation sequencing. The Journal of Molecular Diagnostics. Volume 16, 4; pages 405-417, 2014. Elsevier.
Spencer, David H; Abel, Haley J; Lockwood, Christina M; Payton, Jacqueline E; Szankasi, Philippe; Kelley, Todd W; Kulkarni, Shashikant; Pfeifer, John D; Duncavage, Eric J; Detection of FLT3 internal tandem duplication in targeted, short-read-length, next-generation sequencing data. The Journal of Molecular Diagnostics. Volume 15, 1; pages 81-93, 2013. Elsevier.
Spencer, David H; Sehn, Jennifer K; Abel, Haley J; Watson, Mark A; Pfeifer, John D; Duncavage, Eric J; Comparison of clinical targeted next-generation sequence data from formalin-fixed and fresh-frozen tissue specimens. The Journal of Molecular Diagnostics. Volume 15, 5; pages 623-633, 2013. Elsevier.
Duncavage, Eric J; Abel, Haley J; Szankasi, Philippe; Kelley, Todd W; Pfeifer, John D; Targeted next-generation sequencing of clinically significant gene mutations and translocations in leukemia. Modern Pathology. Volume 25, 6; pages 795-804, 2012. Nature Publishing Group.

Assistant:
Dani Salazar
314-362-2975
sdaniela@wustl.edu