Claudia Han, PhD
Assistant Professor, Pathology and Immunology
- Phone: 314-273-2288
- Email: claudiah@nospam.wustl.edu
Division
- Immunobiology
Additional Titles
- Assistant Professor, Center for Brain Immunology and Glia
Education
- BA in Biological Sciences: Cornell University
- PhD: University of Virginia School of Medicine
Professional Recognition
- BRAIN Initiative K99/R00 Awardee, 2022
- Irvington Postdoctoral Fellowship, CRI, 2018-2021
Research Statement
Our interest lies in elucidating the function of various brain macrophages in neuropathology and the molecular mechanisms driving these phenotypes. We utilize a variety of techniques including genomics, stem cell modeling and genetic mouse models.
Publications
| Han CZ, Li RZ, Hansen E, Trescott S, Fixsen BR, Nguyen CT, Mora CM, Spann NJ, Bennett HR, Poirion O, Buchanan J, Warden AS, Xia B, Schlachetzki JCM, Pasillas MP, Preissl S, Wang A, O’Connor C, Shriram S, Kim R, Schafer D, Ramirez G, Challacombe J, Anavim SA, Johnson A, Gupta M, Glass IA; Birth Defects Research Laboratory; Levy ML, Haim SB, Gonda DD, Laurent L, Hughes JF, Page DC, Blurton-Jones M, Glass CK, Coufal NG. Human microglia maturation is underpinned by specific gene regulatory networks. Immunity. 2023 Sep 12;56(9):2152-2171.e13. doi: 10.1016/j.immuni.2023.07.016. Epub 2023 Aug 14. PMID: 37582369; PMCID: PMC10529991. |
| Fixsen BR, Han CZ, Zhou Y, Spann NJ, Saisan P, Shen Z, Balak C, Sakai M, Cobo I, Holtman IR, Warden AS, Ramirez G, Collier JG, Pasillas MP, Yu M, Hu R, Li B, Belhocine S, Gosselin D, Coufal NG, Ren B, Glass CK. SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity. Nat Immunol. 2023 Jul;24(7):1188-1199. doi: 10.1038/s41590-023-01528-8. Epub 2023 Jun 15. PMID: 37322178; PMCID: PMC10307637. |
| Nott A, Holtman IR, Coufal NG, Schlachetzki JCM, Yu M, Hu R, Han CZ, Pena M, Xiao J, Wu Y, Keulen Z, Pasillas MP, O’Connor C, Nickl CK, Schafer ST, Shen Z, Rissman RA, Brewer JB, Gosselin D, Gonda DD, Levy ML, Rosenfeld MG, McVicker G, Gage FH, Ren B, Glass CK. Brain cell type-specific enhancer-promoter interactome maps and disease–risk association. Science. 2019 Nov 29;366(6469):1134-1139. doi: 10.1126/science.aay0793. Epub 2019 Nov 14. PMID: 31727856; PMCID: PMC7028213. |
| Han CZ, Juncadella IJ, Kinchen JM, Buckley MW, Klibanov AL, Dryden K, Onengut-Gumuscu S, Erdbrügger U, Turner SD, Shim YM, Tung KS, Ravichandran KS. Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation. Nature. 2016 Nov 24;539(7630):570-574. doi: 10.1038/nature20141. Epub 2016 Nov 7. PMID: 27820945; PMCID: PMC5799085. |
Assistants:
Tracy Duckett
314-273-2288
duckettt@wustl.edu
Randi Lee
314-273-1733
Lee.r@wustl.edu
BJC-IOH Room 8602