Changqing (Cathy) Ma, MD, PhD

Division

• Anatomic & Molecular Pathology

Education

• MB, Beijing Medical University, Beijing, China
• PhD, Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA
• Residency, Washington University School of Medicine, St. Louis, MO
• Fellowship, Gastrointestinal and Liver Pathology, Johns Hopkins University School of Medicine, Baltimore, MD

Subspecialties

• Gastrointestinal, pancreatobiliary, and liver pathology

Board Certification

• The American Board of Pathology (ABP) Certification in Anatomic Pathology (AP) and Clinical Pathology (CP)

Clinical Interests

• Gastrointestinal pathology
• Pancreatobiliary pathology
• Liver pathology

Research Interests

The overarching goal of my research is to harness genetics in studying GI inflammatory and neoplastic diseases.

Selected Publications

Ma C, Lowenthal BM, and Pai RK. SATB2 is superior to CDX2 in distinguishing signet ring cell carcinoma of the upper gastrointestinal tract and lower gastrointestinal tract. Am J Surg Pathol. 2018, 42(12):1715-1722. Corresponding author. PMID: 30212392

Gozález I, Goyal B, Xia MD, Pai RK, and Ma C. DNA mismatch repair deficiency but not ARID1A loss is associated with improved prognosis in small intestinal adenocarcinoma. Human Pathol. 2019, 85:18-26. PMID: 30381262

Ma C, Olevian D, Miller C, Herbst C, Jayachandran P, Kozak MM, Chang DT, and Pai RK. SATB2 and CDX2 are prognostic biomarkers in DNA mismatch repair protein deficient colon cancer. Mod Pathol. 2019, 32(8):1217-1231. PMID: 30962505

Ma C, Henn P, Miller C, Herbst C, Hartman DJ, and Pai RK. Loss of SATB2 expression is a biomarker of inflammatory bowel disease-associated colorectal dysplasia and adenocarcinoma. Am J Surg Pathol. 2019, 43(10):1314-1322. PMID: 31318711

Lowenthal BM, Nason KS, Pennathur A, Luketich JD, Pai RK, Davison JM, and Ma C. Loss of ARID1A expression is associated with DNA mismatch repair protein deficiency and favorable prognosis in advanced stage surgically resected esophageal adenocarcinoma. Hum Pathol. 2019, 94:1-10. PMID: 31655170

Villatoro TM, Ma C, and Pai RK. SWI / SNF nucleosome complex-deficient colorectal carcinomas have distinct clinicopathologic features. Hum Pathol. 2020, 99:53-61. PMID: 32222462

Trinh VQ, Shi C, and Ma C. Gastric neuroendocrine tumors from long-term proton pump inhibitor users are indolent tumors with good prognosis. Histopathology. 2020, 77(6):865-876. PMID: 32702178

Farhat L, Hartman DJ, Ma C, Celebrezze J, Medich D, Bahary N, Frank M, Pantanowitz L, Pai RK. Intratumoral budding and automated CD8-positive T-cell density in pre-treatment biopsies can predict response to neoadjuvant therapy in rectal adenocarcinoma. Mod Pathol. 2021, 34(1):171-183. PMID: 32661298

Setia N, Wang C, Lager A, Maron S, Shroff S, Arndt N, Peterson B, Kupfer S, Ma C, Misdraji J, Catenacci D, and Hart J. Morphologic and molecular analysis of early-onset gastric cancer. Cancer. 2021, 127(1):103-114. PMID: 33048355

Ma C, Storer C, Chandran U, LaFramboise WA, Frank M, Hartman DJ, Pantanowitz L, Haritunians T, Head R, and Liu TC. Crohn’s disease-associated ATG16L1 T300A genotype is associated with improved survival in gastric cancer. EbioMedicine. 2021, 67:103347. Co-corresponding author. PMID: 33906066

Alpert L, …, Ma C (author number 8), …, Gonzalez R. Gastrointestinal stromal tumors (GISTs) arising in uncommon locations: clinicopathologic features and risk assessment of esophageal, colonic, and appendiceal GISTs. Mod Pathol. 2022, 35(4):554-563. PMID: 34702994

Ruzinova MB, Ma C, Brunt EM, Goss CW, Vachharajani N, Chapman WC, Liu TC. SOX9 Expression is superior to other stem cell markers K19 and EpCAM in predicting prognosis in hepatocellular carcinoma. Am J Surg Pathol. 2023, 47(1):1-11. PMID: 36322988

Kim DH, Wang Y, Jung H, Field RL, Zhang X, Liu TC, Ma C, Fraser JS, Brestoff JR, Van Dyken SJ. A type 2 immune circuit in the stomach controls mammalian adaptation to dietary chitin. Science. 2023, 381(6662):1092-1098. PMID: 37676935

Gonzalez RS, La Rosa S, Ma C, Polydorides AD, Shi C, Yang Z, Cox B, Karamchandani DM. Debating deposits, redux: substantial interobserver agreement exists in distinguishing tumor deposits from nodal metastases in small bowel neuroendocrine tumors. Arch Pathol Lab Med. 2024, 148(5):581-587. PMID: 37639446

Sutton KA, He M, Ma C, Liu TC, Faubion WA, Hoffmann J, Linneman L, Rodriguez C, Holtz LR. Non-invasive markers of inflammation and protein loss augment diagnosis of pediatric celiac disease. Clin Transl Gastroenterol. 2024, 15(5):e00695. PMID: 38483287

Hu S, …, Ma C (author number 15), …, Xue Y. Clinicopathologic features of gastrointestinal tract Langerhans cell histiocytosis. Mod Pathol. 2024 Jun 17. PMID: 38897453

Ma C, Haritunians T, Gremida AK, Syal G, Shah J, Yang S, Ramos Del Aguila de Rivers C, Storer CE, Chen L, Mengesha E, Mujukian A, Hanna M, Fleshner P, Binion DG, VanDussen KL, Stappenbeck TS, Head RD, Ciorba MA, McGovern DPB, Liu TC. Ileal Paneth cell phenotype is a cellular biomarker for pouch complications in ulcerative colitis. J Crohns Colitis. 2024 Jul 2. PMID: 38953127

Hung CT, Ma C, Panda SK, Trsan T, Hodel M, Frein J, Foster A, Sun S, Wu HT, Kern J, Mishra R, Jain U, Ho YC, Colonna M, Stappenbeck TS, Liu TC. Western diet reduces small intestinal intraepithelial lymphocytes via FXR-Interferon pathway. Mucosal Immunol. 2024 Jul 9. PMID: 38992433

Kashima H, Fischer A, Veronese-Paniagua DA, Gazit VA, Ma C, YanY, Levin MS, Madison BB, Rubin DC. A novel CRISPR/Cas9-mediated mouse model of colon carcinogenesis. Cell Mol Gastroenterol Hepatol. 2024 Aug 9. PMID: 39128652

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Assistant
Lisa Schreiber
lisa.schreiber@wustl.edu
Office: 314-273-4843
Fax: 314-747-2663
BJCIH Room 3422