Chang Liu, MD, PhD

Division

• Laboratory & Genomic Medicine

Additional Titles

• Medical Director, Barnes-Jewish Hospital HLA Laboratory
• Attending Physician, Barnes-Jewish Hospital Transfusion Medicine service
• Director, Histocompatibility and Immunogenetics Fellowship

Education

• MD: Peking Union Medical College, Bejing, China (2004)
• PhD, Cell & Developmental Biology: Vollum Institute, Oregon Health and Science University; Portland, OR (2010)
• Residency, Clinical Pathology: Washington University School of Medicine; St. Louis, MO (2014)
• Fellowship, Transfusion Medicine: Washington University School of Medicine; St. Louis, MO (2014)
• Fellowship, Histocompatibility and Immunogenetic: Barnes-Jewish Hospital/Washington University School of Medicine, Department of Pathology and Immunology (2016)

Board Certifications

• American Board of Pathology, Clinical Pathology, 2014
• American Board of Pathology, Blood Banking and Transfusion Medicine, 2014
• American Society for Histocompatibility and Immunogenetics, Laboratory Director, 2016

Recognition

• Heme Scholar, Clinical Hematology Research Career Development Program at Washington University in St. Louis, 2016
• Best poster award, Resident Research Day, Department of Pathology and Immunology, Washington University School of Medicine, 2014
• Abstract Achievement Award, the 53rd and 54th Annual Meeting of American Society of Hematology, 2012
• AABB-Fenwal Transfusion Medicine Fellow Scholarship Award, the 65th Annual Meeting of AABB, 2012
• Best grand round presentation award, Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, 2011
• Paul E. Strandjord Young Investigator Award, the 46th Annual Meeting of Academy of Clinical Laboratory Physicians and Scientists, 2011
• Vertex Scholar, Vertex Pharmaceuticals and Oregon Health & Science University, 2009

Clinical Interests

• HLA testing
• Pretransfusion testing
• Antibody-mediated rejection
• Alloimmunization after blood transfusion and organ transplantation

Research Interests

Methodology development in HLA typing and serology testing; HLA epitope mismatch and transplant outcome; novel therapies for HLA sensitization and antibody-mediated rejection; HLA and disease association

Selected Publications

Aisihaer X, Guo H, Liu C. Efficient production of soluble class II HLA-DQ complex stabilized by interchain disulfide bond. J Biol Chem. 2024 Aug 7:107652. doi: 10.1016/j.jbc.2024.107652. Epub ahead of print. PMID: 39121997.

Hughes AEO, Montgomery MC, Liu C, Weimer ET. Allele-specific quantification of human leukocyte antigen transcript isoforms by nanopore sequencing. Front Immunol. 2023 Aug 18;14:1199618. doi: 10.3389/fimmu.2023.1199618. PMID: 37662944; PMCID: PMC10471969.

Webber AM, Bradstreet TR, Wang X, Guo H, Nelson CA, Fremont DH, Edelson BT, Liu C. Antigen-guided depletion of anti-HLA antibody-producing cells by HLA-Fc fusion proteins. Blood. 2022 Oct 20;140(16):1803-1815. doi: 10.1182/blood.2022016376. PubMed [citation] PMID: 36070233, PMCID: PMC9837442

Liu C, Yang X, Duffy BF, Hoisington-Lopez J, Crosby M, Porche-Sorbet R, Saito K, Berry R, Swamidass V, Mitra RD. High-resolution HLA typing by long reads from the R10.3 Oxford nanopore flow cells. Hum Immunol. 2021 Apr;82(4):288-295. doi:10.1016/j.humimm.2021.02.005. Epub 2021 Feb 19. PubMed [citation] PMID: 33612390

Liu C. A long road/read to rapid high-resolution HLA typing: The nanopore perspective. Hum Immunol. 2021 Jul;82(7):488-495. doi:10.1016/j.humimm.2020.04.009. Epub 2020 May 1. Review. PubMed [citation] PMID:32386782, PMCID: PMC7606350

Liu C, Duffy BF, Weimer ET, Montgomery MC, Jennemann JE, Hill R, Phelan D, Lay L, Parikh BA. Performance of a multiplexed amplicon-based next-generation sequencing assay for HLA typing. PLoS One. 2020 Apr 23;15(4):e0232050. doi:10.1371/journal.pone.0232050. eCollection 2020. PubMed [citation] PMID: 32324777, PMCID: PMC7179861

Zhang R, Duffy BF, Lange V, Eby CS, Liu C. Association between the HLA-DRB103:01-DQB102:01 haplotype and PF4/heparin antibodies. Blood Adv. 2019 Oct 22;3(20):3136-3142. doi:10.1182/bloodadvances.2019000311. No abstract available. PubMed [citation] PMID: 31648318, PMCID: PMC6849947

Rimando J, Slade M, DiPersio JF, Westervelt P, Gao F, Liu C, Romee R. HLA epitope mismatch in haploidentical transplantation is associated with decreased relapse and delayed engraftment. Blood Adv. 2018 Dec 26;2(24):3590-3601. doi:10.1182/bloodadvances.2018025437. PubMed [citation] PMID: 30563883, PMCID:PMC6306877

Liu C, Xiao F, Hoisington-Lopez J, Lang K, Quenzel P, Duffy B, Mitra RD. Accurate Typing of Human Leukocyte Antigen Class I Genes by Oxford Nanopore Sequencing. J Mol Diagn. 2018 Jul;20(4):428-435. doi: 10.1016/j.jmoldx.2018.02.006. Epub 2018 Apr 3. PubMed [citation] PMID: 29625249, PMCID: PMC6039791

Liu C, Yang X, Duffy B, Mohanakumar T, Mitra RD, Zody MC, Pfeifer JD. ATHLATES: accurate typing of human leukocyte antigen through exome sequencing. Nucleic Acids Res. 2013 Aug;41(14):e142. doi: 10.1093/nar/gkt481. Epub 2013 Jun 8. PubMed [citation] PMID: 23748956, PMCID: PMC3737559

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Shelley Cuervo
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