Brian Edelson, MD, PhD

Assistant Professor, Pathology & Immunology

Additional Titles

  • Course Director, First Year Immunology

Education

  • BS: Brown University, Providence RI (1995)
  • PhD, MD: Washington University School of Medicine, St. Louis, MO (2004)
  • Residency, Clinical Pathology: Barnes-Jewish Hospital, St. Louis, MO (2009)
  • Postdoctoral Work: Washington University School of Medicine, St. Louis, MO (2010)

Board Certifications

  • Diplomate, Missouri State Board of Registration for the Healing Arts
  • American Board of Pathology, Clinical Pathology

Clinical Interests

  • Immunology

Research Interests

My laboratory is focused on two areas of immunology. First, we are interested in understanding how autoreactive T cells mediate autoimmune disease, particularly in multiple sclerosis (MS) and its mouse model, experimental autoimmune encephalomyelitis (EAE). We focus on how cytokine expression is regulated in autoreactive T cells in a cell-intrinsic manner through the action of transcription factors, and how these cytokines mediate disease pathogenesis. We are particularly interested in how T cell expression of granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin-10 (IL-10) is regulated, and how these cytokines act on cells of the innate immune system during autoimmune disease.

My laboratory’s work in this area led to our discovery that the transcription factor Bhlhe40 regulates cytokine production by CD4+ T cells. Second, we are interested in understanding the development, heterogeneity, and function of monocytes, macrophages, and dendritic cells during immune responses. We use a variety of gene-deficient mice to analyze how specific monocyte, macrophage, and dendritic cell subsets carry out their non-redundant roles during autoimmunity and infection. We employ the mouse model of Listeria monocytogenes infection in many of these experiments.

DBBS Graduate Program Affiliation

  • Immunology
  • Molecular Microbiology and Microbial Pathogenesis

Publications

Pub Med Search

Huynh, J.P., Lin, C.-C., Kimmey, J.M., Jarjour, N.N., Schwarzkopf, E.A., Bradstreet, T.R., Shchukina, I., Shpynov, O., Weaver, C.T., Taneja, R., Artyomov, M.N., Edelson, B.T.*, Stallings, C.L*. (2018) Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection. J Exp Med. 2018 Jul 2;215(7):1823-1838. PMCID: PMC6028511 *co-corresponding authors.  Abstract
Lin, C.-C., Edelson, B.T. (2017) New insights into the role of IL-1β in experimental autoimmune encephalomyelitis and multiple sclerosis. J. Immunol. 198(12), 4553-4560. PMCID: PMC5509030   Abstract
Lin, C.-C., Bradstreet, T.R., Schwarzkopf, E.A., Jarjour, N.N., Chou, C., Archambault, A.S., Sim, J., Zinselmeyer, B.H., Carrero, J.A., Wu, G.F., Taneja, R., Artyomov, M.N., Russell, J.H., Edelson, B.T. (2016) IL-1-induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation. J. Exp. Med. 213(2), 251-271. PMCID: PMC4749922    Abstract
Lin, C.-C., Bradstreet, T.R., Schwarzkopf, E.A., Sim, J., Carrero, J.A., Chou, C., Cook, L.E., Egawa, T., Taneja, R., Murphy, T.L., Russell, J.H., Edelson, B.T. (2014) Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation. Nat. Commun. 5:3551. PMCID: PMC4016562   Abstract
Edelson, B.T., Bradstreet, T.R., KC, W., Hildner, K., Herzog, J.W., Sim, J., Russell, J.H., Murphy, T.L., Unanue, E.R., Murphy, K.M. (2011) Batf3-dependent CD11blow/- peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization. PLoS ONE. 6(10), e25660. PMCID: PMC3196467  Abstract
Edelson, B.T., Bradstreet, T.R., Hildner, K., Carrero, J.A., Frederick, K.E., KC, W., Belizaire, R., Aoshi, T., Schreiber, R.D., Miller, M.J., Murphy, T.L., Unanue, E.R., Murphy, K.M. (2011). CD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes. Immunity. 35(2), 236-248. PMCID: PMC3172670  Abstract
Edelson, B.T., KC, W., Juang, R., Kohyama, M., Benoit, L.A., Klekotka, P.A., Moon, C., Albring, J.C., Ise, W., Michael, D.G., Bhattacharya, D., Stappenbeck, T.S., Holtzman, M.J., Sung, S.J., Murphy, T.L., Hildner, K., Murphy, K.M. (2010). Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells. J. Exp. Med. 207(4), 823-836. PMCID: PMC2856032  Abstract

Assistant
Randi Lee
314-273-1733
Lee.r@wustl.edu

Lab Phone: 314-362-4428