Aayushi Uberoi, PhD

Aayushi Uberoi, PhD

Assistant Professor, Pathology & Immunology

Division

  • Laboratory and Genomic Medicine

Education

  • B.Tech (Hons): SRM School of Engineering, SRM University, Chennai, India (2011)
  • Ph.D. (Cancer Biology): University of Wisconsin-Madison, U.S.A. (2017)

Recognition

  • Society of Investigative Dermatology Type II Innovator Award (2024)
  • Thermo Fisher Scientific-Applied Biosciences 40th Anniversary:40 Innovative scientists worldwide (2023)
  • National Institutes of Health K99/R00: Pathway to Independence Award (2022-Present)
  • Career Development Award, Dermatology Foundation (2021)
  • Awesome Games Done Quick Fellow of Prevent Cancer Foundation (2020-2021)
  • Young Investigator Award, Wound Healing Society (2020)
  • Joshua Neimark Research Award, American Association for Advancement of Science (2016)
  • Dr. Hargobind Khorana Award by the Indo-US Science and Technology Forum (2010)
  • Research fellow, Indian Academy of Sciences, Govt. of India (2009)
  • Research fellow, Jawaharlal Nehru Centre for Advanced Scientific Research (2008)

Lab Website

Research Statement

The skin provides the first line of defense for all vertebrates. An effective skin barrier is essential to life and protects the underlying organs from dehydration, inflammation, environmental exposure, and infections. The skin houses the skin microbiome which is unique and distinct in its composition and plays a critical role in educating the skin barrier defenses. My lab’s research program aims to identify molecular and biochemical mechanisms that mediate microbial symbiosis with host skin. In this context we are interested in understanding how microbiome impacts skin barrier repair and regeneration in state of homeostasis and disease (e.g., chronic wounds, atopic dermatitis and cancer).

Selected Publications

PubMed Search
Campbell AE, McCready-Vangi AR, Uberoi A, Murga-Garrido SM, Lovins VM, White EK, Pan JT, Knight SAB, Morgenstern AR, Bianco C, Planet PJ, Gardner SE, Grice EA. Variable staphyloxanthin production by Staphylococcus aureus drives strain-dependent effects on diabetic wound-healing outcomes. Cell Rep. 2023 Oct 31;42(10):113281. doi: 10.1016/j.celrep.2023.113281. Epub 2023 Oct 19. PubMed PMID: 37858460; PubMed Central PMCID: PMC10680119.
Sutter CH, Azim S, Wang A, Bhuju J, Simpson AS, Uberoi A, Grice EA, Sutter TR. Ligand Activation of the Aryl Hydrocarbon Receptor Upregulates Epidermal Uridine Diphosphate Glucose Ceramide Glucosyltransferase and Glucosylceramides. J Invest Dermatol. 2023 Oct;143(10):1964-1972.e4. doi: 10.1016/j.jid.2023.03.1662. Epub 2023 Mar 31. PubMed PMID: 37004877; PubMed Central PMCID: PMC10529782.
Wei M, Flowers L, Knight SAB, Zheng Q, Murga-Garrido S, Uberoi A, Pan JT, Walsh J, Schroeder E, Chu EW, Campbell A, Shin D, Bradley CW, Duran-Struuck R, Grice EA. Harnessing diversity and antagonism within the pig skin microbiota to identify novel mediators of colonization resistance to methicillin-resistant Staphylococcus aureus. mSphere. 2023 Aug 24;8(4):e0017723. doi: 10.1128/msphere.00177-23. Epub 2023 Jul 5. PubMed PMID: 37404023; PubMed Central PMCID: PMC10449522.
White EK, Uberoi A, Pan JT, Ort JT, Campbell AE, Murga-Garrido SM, Harris JC, Bhanap P, Wei M, Robles NY, Gardner SE, Grice EA. Wound microbiota-mediated correction of matrix metalloproteinase expression promotes re-epithelialization of diabetic wounds. bioRxiv. 2023 Jun 30;. doi: 10.1101/2023.06.30.547263. PubMed PMID: 37425836; PubMed Central PMCID: PMC10327199.
Flowers L, Campbell A, Uberoi A. Cutibacterium acnes evolution: One pore at a time. Cell Host Microbe. 2022 Feb 9;30(2):144-146. doi: 10.1016/j.chom.2022.01.007. PubMed PMID: 35143764.
Wei T, Grace M, Uberoi A, Romero-Masters JC, Lee D, Lambert PF, Munger K. The Mus musculus Papillomavirus Type 1 E7 Protein Binds to the Retinoblastoma Tumor Suppressor: Implications for Viral Pathogenesis. mBio. 2021 Aug 31;12(4):e0227721. doi: 10.1128/mBio.02277-21. Epub 2021 Aug 31. PubMed PMID: 34465025; PubMed Central PMCID: PMC8406179.
Uberoi A, Bartow-McKenney C, Zheng Q, Flowers L, Campbell A, Knight SAB, Chan N, Wei M, Lovins V, Bugayev J, Horwinski J, Bradley C, Meyer J, Crumrine D, Sutter CH, Elias P, Mauldin E, Sutter TR, Grice EA. Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor. Cell Host Microbe. 2021 Aug 11;29(8):1235-1248.e8. doi: 10.1016/j.chom.2021.05.011. Epub 2021 Jul 1. PubMed PMID: 34214492; PubMed Central PMCID: PMC8364505.
Yu L, Majerciak V, Xue XY, Uberoi A, Lobanov A, Chen X, Cam M, Hughes SH, Lambert PF, Zheng ZM. Mouse papillomavirus type 1 (MmuPV1) DNA is frequently integrated in benign tumors by microhomology-mediated end-joining. PLoS Pathog. 2021 Aug;17(8):e1009812. doi: 10.1371/journal.ppat.1009812. eCollection 2021 Aug. PubMed PMID: 34343212; PubMed Central PMCID: PMC8362953.
Torres AD, Spurgeon ME, Bilger A, Blaine-Sauer S, Uberoi A, Buehler D, McGregor SM, Ward-Shaw E, Lambert PF. The human papillomavirus 16 E5 gene potentiates MmuPV1-Dependent pathogenesis. Virology. 2020 Feb;541:1-12. doi: 10.1016/j.virol.2019.12.002. Epub 2019 Dec 5. PubMed PMID: 31826841; PubMed Central PMCID: PMC7024000.
Wang W, Uberoi A, Spurgeon M, Gronski E, Majerciak V, Lobanov A, Hayes M, Loke A, Zheng ZM, Lambert PF. Stress keratin 17 enhances papillomavirus infection-induced disease by downregulating T cell recruitment. PLoS Pathog. 2020 Jan;16(1):e1008206. doi: 10.1371/journal.ppat.1008206. eCollection 2020 Jan. PubMed PMID: 31968015; PubMed Central PMCID: PMC6975545.

Assistant’s information:
Ellen Lockett
Ellen.l@wustl.edu
314-362-3056
Office Location: CSRB 7739B