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Jacqueline Payton, MD, PhD

Assistant Professor, Pathology & Immunology

Fax314-362-8888

Emailjpayton@wustl.edu

Additional Titles

  • Medical Director, Molecular Diagnostics Laboratory
  • Director, Clinical Pathology Physician Scientist Training Program

Related Links

Education

  • BS: Bradley University, Peoria, IL (1996)
  • PhD: University of Illinois Urbana-Champaign, Urbana, IL (2002)
  • Genetic Epidemiology Certificate Program: Washington University, St. Louis, MO (2007)
  • Clinical Pathology Residency: Washington University and Barnes-Jewish Hospital, St. Louis, MO (2008)

Board Certifications

  • Diplomate, American Board of Pathology, Clinical Pathology, 2008

Recognition

  • Distinguished Investigator Award, Washington University School of Medicine, 2016
  • International Assoc. for Comparative Research on Leukemia & Related Diseases Travel Award, 2009
  • College of American Pathologists Foundation Research Scholar Award, 2008
  • Paul E. Strandjord Young Investigator Award, Academy of Clinical Laboratory Physicians & Scientists, 2007
  • University of Illinois at Chicago College of Medicine Charles Spencer Williamson Award, Internal Medicine, 2004
  • Pediatrics Award, University of Illinois at Chicago College of Medicine at Urbana-Champaign, 2004
  • American Medical Women’s Association Janet M. Glasgow Memorial Citation, University of Illinois at Chicago College of Medicine at Urbana-Champaign, 2004
  • Medical Scholars Program Certificate, University of Illinois at Chicago College of Medicine at Urbana-Champaign, 2004
  • MD with Honors, Alpha Omega Alpha Medical Honor Society, elected as a Junior, University of Illinois at Chicago College of Medicine at Urbana-Champaign, 2004
  • Scholar Award from P.E.O. Sisterhood, a philanthropic educational organization, 2003
  • Daniel K. and Frances A. Bloomfield Fellowship, University of Illinois at Chicago College ofMedicine at Urbana-Champaign Medical Scholars Program, 2003
  • Otto Saphir Award for Excellence in Pathology, University of Illinois at Chicago College of Medicine, 2003
  • American Federation for Aging Research Scholarship, 2002
  • Developmental Psychobiology and Neurobiology Training Grant, University of Illinois at Urbana-Champaign, 1999
  • Paul D. Doolen Graduate Scholarship, Alternate, 1998
  • Harry J. Diffenbaugh Fellowship, 1997

  • Howard Hughes Predoctoral Fellowship Honorable Mention, 1997

  • Enhancement Scholarship, University of Illinois at Chicago College of Medicine at Urbana-Champaign Medical Scholars Program, 1996

  • Summa Cum Laude, Bradley University, Peoria, IL, 1996

  • Winner, Science Division, Bradley University Research Symposium, Peoria, IL, 1996

  • Outstanding Senior in Biology and Academic Wall of Fame, Bradley University, Peoria, IL, 1996

  • National Merit Scholarship, Bradley University, Peoria, IL, 1992-1996

Clinical Interests

  • Molecular Pathology

Research Interests

The Payton Lab is a “damp” lab that integrates -omics discovery via bioinformatic analysis of large datasets with cellular and molecular experimental models to elucidate novel regulatory mechanisms. Our research focuses on the roles of non-coding regulatory elements in promoting cellular transformation and cancer, specifically in Non-Hodgkin Lymphoma. Using chromatin profiling, we identified novel enhancers that are recurrently altered in primary NHL tumors and perturb the expression of genes involved in cellular transformation (Koues et al, Immunity, 2015). We also demonstrated that mutations in enhancers alter their function by abrogating transcription factor binding and reducing target gene transcription.

In parallel studies, we are developing therapeutic approaches that specifically target lymphoma-altered enhancers for epigenetic reversal (Luo et al, 2016). While examining these NHL enhancers, we discovered an enrichment of novel and annotated long non-coding RNAs (lncRNA) with altered activity in lymphoma B cells. The Payton lab is investigating these lncRNAs, in order to elucidate novel mechanisms by which they regulate or modulate lymphomagenic pathways. Our ultimate goal is to identify novel pathways and regulatory elements that may be future therapeutic targets in hematologic malignancy.

DBBS Affiliation:

  • Molecular Genetics and Genomics Program

Publications

Pub Med Search


Assistant:

Jennifer Schwierjohn

314-362-3056

j.schwierjohn@wustl.edu