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Jack Ladenson, PhD

Jack H. Ladenson, PhD

Oree M. Carroll and Lillian B. Ladenson Professor of Clinical Chemistry, Pathology & Immunology
Co-Medical Director, Clinical Chemistry

Phone314-454-8436

Fax314-362-5208

Emailladenson@wustl.edu

Additional Titles

  • Professor, Medicine

Education

  • BS: Pennsylvania State University, University Park, PA (1964)
  • PhD in Analytical Chemistry with Professor William C. Purdy: University of Maryland, College Park, MD (1971)
  • Post-doctoral training in Clinical Chemistry with George N. Bowers, Jr., MD, Robert B. McComb, PhD and Robert W. Burnett, PhD: Hartford Hospital, Hartford, CT (1970-1972)

Board Certifications

  • Certified in Clinical Chemistry by the American Board of Clinical Chemistry - 1974

Recognition

  • 1989 American Association for Clinical Chemistry Award for Outstanding Contributions in Education
  • 1990 Certificate of Honor – New Jersey Section – American Association for Clinical Chemistry
  • 1994 Distinguished Scientist Award, Clinical Ligand Assay Society
  • 1994 Outstanding Contributions to Clinical Chemistry Award, American Association for Clinical Chemistry
  • 1994 Manitoba Society of Clinical Chemists Lectureship Award
  • 1994 Bernard Gerulat Memorial Award of the New Jersey Section, AACC
  • 1999 Gerald T. Evans Award of the Academy of Clinical Laboratory Physicians and Scientists
  • 2002 American Association for Clinical Chemistry Award for Outstanding Contributions to Clinical Chemistry in a Selected Area of Research
  • 2003 Distinguished Service Award – Washington University Medical Center Alumni Association
  • 2003 Presidential Citation from Susan Evans, Ph.D., President of The American Association for Clinical Chemistry (AACC) for Pathologists Overseas work in developing countries
  • 2004 Cotlove Award Lecturer – Academy of Clinical Laboratory Physicians and Scientists (ACLPS)
  • 2005 IFCC/Bayer Wishinsky Award for Distinguished International Service
  • 2006 Mentor of the Year Award of the Academic Women’s Network of Washington University School of Medicine
  • 2010 WUSM Distinguished Community Service Award
  • 2010 Inaugural Recipient of the Chancellor’s Award for Innovation and Entrepreneurship
  • 2011 Norman P. Kubasik Lectureship Award

Clinical Interests

  • Clinical Chemistry

Research Interests

My laboratory has long been interested in the development of rapid, accurate techniques for the diagnosis and/or prognosis of human disease and the enhancement of basic or clinical research. Our previous work concerned the diagnosis of myocardial infarction (MI). A monoclonal antibody specific to the creatine kinase-MB (CK-MB) isoenzyme was developed which does not react with CK-BB, CK-MM or mitochondrial CK. This antibody is now widely utilized in virtually all commercially available assays for CK-MB. The work was extended to the development of the first and still most widely utilized assays for Troponin I and myoglobin. We have also developed a monoclonal antibody to calmodulin, a highly conserved protein throughout animal species and plants which has proved to be a very useful reagent for research investigations. Our current work involves the development and validation of assays to improve the diagnosis of renal damage and the diagnosis and prognosis of neurodegerative disease such as Alzheimer’s.

For the last twenty years, I have run the clinical pathology programs for Pathologists Overseas, an organization whose mission is to help improve and provide affordable pathology and clinical laboratory services to under-served patients worldwide. This has lead to a variety of short-term projects, as well as long-term projects in the countries of Eritrea and Bhutan. These efforts, sustained by volunteers, have the goal of upgrading laboratory services, upgrading the training of laboratory personnel, extending laboratory testing to regional hospitals, clinician education, and helping to develop standardized national laboratory systems.

Service to the Department

2003 – 2008 Interim Director, Division of Laboratory Medicine

Diagnostic Expertise

  • Clinical Chemistry
  • Biomarkers
  • Laboratory Medicine in developing countries

Publications

Pub Med Search

Tarawneh R, Head D, Allison S, Buckles V, Fagan AM, Ladenson JH, Morris JC, Holtzman DM.Cerebrospinal Fluid Markers of Neurodegeneration and Rates of Brain Atrophy in Early Alzheimer Disease. JAMA Neurol, 2015; 72: 656-65 Abstract
Gaut JP, Crimmins DL, Ohlendorf MF, Lockwood CM, Griest TA, Brada NA, Hoshi M, Sato B, Hotchkiss RS, Jain S, Ladenson JH. Development of an Immunoassay for the Kidney-Specific Protein myo-Inositol Oxygenase; a Potential Biomarker of Acute Kidney Injury. Clin Chem 60(5):747-757, 2014 Abstract
Kester Mi, Teunissen CE, Crimmins DL, Herries EM, Ladenson JH, Schelten P, van der Flier WM, Morris JC, Holtzman DM, Fagan AM.  Neurogranin as A CSF biomarker for synaptic loss in symptomatic Alzheimer’s disease.  JAMA Neurol 72(11): 1275-80. 2015 Abstract
Sutphen CL, Jasielec MS, Shah AR, Macy EM, Xiong C, Vlassenko AG, Benzinger TSL, Stoops EEJ, Vanderstichele HMJ, Brix B, Darby HD, Vandijck MLJ, Ladenson JH, Morris JC, Holtzman DM, Fagan AM.  Longitudinal cerebrospinal fluid biomarker changes in preclinical Alzheimer Disease during middle age.  JAMA Neurol 72(9): 1029-42. 2015 Abstract
Kester Mi, Teunissen CE, Sutphen C. Herries Em, Ladenson JH, Xiong C, et al.  Cerebrospinal fluid VILIP-1 and YKL-40, candidate biomarkers to diagnose, predict and monitor Alzheimer’s disease in a memory clinic cohort.  Alzheimer’s Res Ther 7(1): 59. 2015 Abstract
Fagan AM, Xiong C, Jasielec MS, Bateman RJ, Goate AM, Benzinger TLS, Ghetti B, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Salloway S, Schofield PR, Sperling RA, Marcus D, Cairns NJ, Buckles VD, Ladenson JH, Morris JC, Holtzman DM. Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimers Disease. Science Translational Medicine 6(226):226ra30, 2014 Abstract
Tarawneh R, Lee JM, Ladenson JH, Morris JC, Holtzman DM. CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease. Neurology 78:709-19, 2012 Abstract
Rifai N, Diamandis EP, Lo YMD, Kricka LJ, Wilding P, Ladenson JH, Wittwer CT. Advancing Laboratory Medicine through Innovation: A Tale of Six Inventors. Clin Chem 58:502-10, 2012 Abstract
Tarawneh R, D. Visinin-like protein-1: Diagnostic and prognostic biomarker in Alzheimer disease. Ann Neurol 70:274-85, 2011 Abstract
Ladenson, JH. Troponin I, The Story. Clin Chem 56:482-483, 2010 Abstract
Lee JM, Blennow K, Andreasen N, Laterza O, Modur V, Olander J, Gao F, Ohlendorf M, Ladenson JH. The brain injury biomarker VLP-1 is increased in the cerebrospinal fluid of Alzheimer disease patients. Clin Chem 54:1617-1623, 2008 Abstract
Ladenson JH. A personal history of markers of myocyte injury [myocardial infarction]. Clinica Chimica Acta 381(1):3-8, 2007 Abstract
Scott MG, Morin S, Hock KG, Seyoum M, Ladenson JH. Establishing a simple and sustainable quality assurance program and clinical chemistry services in Eritrea. Clin Chem 53(11):1945-1953, 2007 Abstract
Windus DW, Ladenson JH, Merrins CK, Seyoum M, Windus D, Morin S, et al. Impact of a multidisciplinary intervention for diabetes in Eritrea. Clin Chem 53(11):1954-1959, 2007 Abstract
Laterza OF, Modur VR, Crimmins DL, Olander JV, Landt Y, Lee JM, Ladenson JH. Identification of novel brain biomarkers. Clin Chem: 52:1713-1721, 2006 Abstract
Ladenson RC, Crimmins DL, Landt Y, Ladenson JH. Isolation and characterization of a thermally stable recombinant anti-caffeine heavy-chain antibody fragment. Anal Chem 78:4501-4508, 2006 Abstract
Rosalki SB, Roberts R, Katus HA, Giannitsis E, Ladenson JH. Cardiac biomarkers for detection of myocardial infarction: Perspectives from past to present. Clin Chem 50:2205-2213, 2004 Abstract
Ladenson JH, Scott MG, Klarkowski D, Seyoum M. The Use of a Major Medical Center Clinical Laboratory as a Reference Laboratory for a Developing Country. Clin Chem 49:162-166, 2003 Abstract
Adams III, JE, Bodor GS, Dàvila-Roman VG, Delmez JA, Apple FS, Ladenson JH, Jaffe AS.Cardiac troponin-I: a marker with high specificity for cardiac injury. Circulation 88:101-10, 1993 Abstract
Bodor GS, Porter S, Landt Y, Ladenson JH. Development of monoclonal antibodies for an assay of cardiac troponin-I and preliminary results in suspected cases of myocardial infarction. Clin Chem 38:2203-2214, 1992 Abstract
Silva DP, Landt Y, Porter SE, Ladenson JH. Development and application of monoclonal antibodies to human cardiac myoglobin in a rapid fluorescence immunoassay. Clin Chem 37:1356-1364, 1991 Abstract
Vaidya HC, Maynard Y, Ladenson JH. Direct measurement of creatine kinase-MB activity in serum after extraction with a monoclonal antibody specific to the MB isoenzyme.  Clin Chem 32: 657-63, 1986 Abstract


Assistant
Ann Winn
314-454-8436
awinn@wustl.edu

Office Location: BJC-IH Building, Room 4418