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Eynav Klechevsky, PhD

Eynav Klechevsky, PhD

Assistant Professor, Pathology & Immunology

Phone314-286-0897

Emaileklechevsky@wustl.edu

Research Interests

The ability to distinguish between physiological and pathogenic antigens and to make decisions about how to respond to particular pathogens or a disease condition signifies a properly functioning adaptive immune system. Dendritic cells (DCs), a diverse family of antigen presenting cells, are required to explain how these specific responses are initiated and controlled. Our work on the immune system is focused on the biology of DCs in humans. Using cellular and molecular techniques we are examining the specializations that make DC subsets so adept at detecting inflammatory signals, and driving different modules of acquired immune responses. The role that individual DC subsets provide in directing adaptive immunity is also critical to our understanding human disease, and guides us in identifying new principles and practices that would hopefully lead to new treatments for some of the challenging human diseases.

DBBS Graduate Program Affiliation

  • Immunology
  • Computational and Systems Biology Program
  • Molecular Microbiology and Microbial Pathogenesis

Publications

Pub Med Search

Artyomov, M.N.*, Munk, A.*, Gorvel, L., Korenfeld, D., Cella, M., Tung, T., Klechevsky, E.. Modular expression analysis reveals functional conservation between human Langerhans Cells and mouse cross-priming dendritic cells. J Exp Med. 2015 Apr 27, 2015 Abstract
Klechevsky, E.. Human Dendritic Cells – Stars in the Skin. Eur J Immunol., 2013 Abstract
Banchereau, J., Zurawski, S., Thompson-Snipes, L., Blanck, J.P., Clayton, S., Munk, A., Cao, Y., Wang, Z., Khandelwal, S., Hu, J., McCoy, W.H. 4th, Palucka, K.A., Reiter, Y., Fremont, D.H., Zurawski, G., Colonna, M., Shaw, A.S., Klechevsky, E.. Immunoglobulin-like transcript receptors on human dermal CD14+ dendritic cells act as a CD8-antagonist to control cytotoxic T cell priming. Proc Natl Acad Sci USA. Nov 13;109(46):18885-90., 2012 Abstract
Banchereau, J., Thompson-Snipes, L., Zurawski, S., Blanck, J.P., Cao, Y., Clayton, S., Gorvel, J.P., Zurawski, G., Klechevsky, E.. The differential production of cytokines by human Langerhans Cells and dermal CD14+ DCs controls CTL priming. Blood. Jun 14;119(24):5742-9., 2012 Abstract
Ueno H, Klechevsky E, Schmitt N, Ni L, Flamar AL, Zurawski S, Zurawski G, Palucka K, Banchereau J, Oh S.. Targeting human dendritic cell subsets for improved vaccines. Semin Immunol. Feb;23(1):21-7., 2011 Abstract
Klechevsky E, Flamar AL, Cao Y, Blanck JP, Liu M, O. Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR. Blood. Sep 9;116(10):1685-97., 2010 Abstract
Klechevsky E, Liu M, Morita R, Banchereau R, Thompson-Snipes L, Palucka AK, Ueno H, Banchereau J.. Understanding human myeloid dendritic cell subsets for the rational design of novel vaccines. Hum Immunol. May;70(5):281-8., 2009 Abstract
Klechevsky E, Morita R, Liu M, Cao Y, Coquery S, Thompson-Snipes L, Briere F, Chaussabel D, Zurawski G, Palucka AK, Reiter Y, Banchereau J, Ueno H.. Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells. Immunity. Sep 19;29(3):497-510., 2008 Abstract
Ueno H, Klechevsky E, Morita R, Aspord C, Cao T, Matsui T, Di Pucchio T, Connolly J, Fay JW, Pascual V, Palucka AK, Banchereau J.. Dendritic cell subsets in health and disease. Immunol Rev. Oct;219:118-42. Review., 2007 Abstract
Klechevsky E, Kato H, Sponaas AM.. Dendritic cells star in Vancouver. J Exp Med. Jul 4;202(1):5-10., 2005 Abstract


Lab Phone: 314-747-6688
Office Location: BJC-IH Building, Office Suite B 8210