Eynav Klechevsky, PhD

Division

• Immunobiology

Education

• BSc, Molecular Biochemistry (Magna Cum laude), Technion – Israel Institute of Technology, Haifa, Israel
• MSc, awarded during the direct PhD program – Technion – Israel Institute of Technology, Haifa, Israel
• PhD, (excellence direct PhD program) – Immunology Technion – Israel Institute of Technology, Haifa, Israel and The Baylor Institute for Immunology Research; Dallas, TX

Research Lab

• Klechevsky Lab

Twitter Handle

• @klechevskyLab

Research Interests

The ability to distinguish between physiological and pathogenic antigens and to make decisions about how to respond to particular pathogens or a disease condition signifies a properly functioning adaptive immune system. Dendritic cells (DCs), a diverse family of antigen-presenting cells, are required to explain how these specific responses are initiated and controlled. Our work on the immune system is focused on fundamental and translational aspects of dendritic cell biology in healthy tissue, and their aberrant functions and distribution in disease. Leveraging our broad and deep expertise in human immunology, we are addressing using human patient samples and disease models longstanding questions related to basis for the functional specialization of human DC subtypes including, the selective co-receptor and cytokine production during immune responses, T cell skewing, differentiation and involvement in disease. Our work has revealed the discovery of a new inflammatory dendritic cell type and mechanisms we have exploited to enhance immune-based treatment efficiency in cancer and autoimmunity, ultimately with the goal of harnessing these mechanisms for the development of new vaccines and immunotherapies for some of the challenging human diseases.

DBBS Affiliation

• Immunology Program Co-Director
• Cancer Biology Program
• Molecular Microbiology and Microbial Pathogenesis Program
• Computational and Systems Biology Program

Selected Publications

Korenfeld D., Dinkel S., Vogel T.P., Pollack H., Levy J., Leiding J.W., Milner J., Cooper M., Klechevsky E. STAT3 gain-of-function mutations underline deficiency in human non-classical CD16+ monocytes and CD141+ dendritic cells. (2021) J Immunol. 2021 Oct 15;. doi: 10.4049/jimmunol.2000841. DOI: 10.4049/jimmunol.2000841.

Ma F., Hughes T., Teles R., Andrade P., Silva B., Plazyo O., Tsoi L., Do T., Wadsworth M., Oulee A., Ochoa M., Sarno E., Iruela-Arispe ML., Klechevsky E., Bryson B., Shalek A., Bloom B., Gudjonsson J., Pellegrini M. Single Cell and Spatial Transcriptomics Defines the Cellular Architecture of the Antimicrobial Response Network in Human Leprosy Granulomas Nat. Immunol. Nat Immunol. 2021 Jul;22(7):839-850. Epub 2021 Jun 24. Doi: 10.1038/s41590-021-00956-8.

Galani IE, Klechevsky E, Andreakos E. Human and translational immunology in the third millennium: progress, challenges and opportunities. *co-corresponding author Nat Immunol. 2019 Dec;20(12):1568-1573. PMID: 31745346. doi: 10.1038/s41590-019-0543-6.

Korenfeld, D., Gorvel, L., Munk, A., Man, J., Schaffer, A., Tung, T., Mann, C., Klechevsky, E. A type of human skin dendritic cell marked by CD5 is associated with the development of inflammatory skin disease. (2017) JCI Insight. Sep 21;2(18). PMCID: PMC5621884 • DOI: 10.1172/jci.insight.96101.

Gorvel, L., Korenfeld, D., Tung, T., Klechevsky, E. (2017) Dendritic Cell-Derived IL-32α: A Novel Inhibitory Cytokine of NK Cell Function. J Immunol. 199(4):1290-1300. PMCID: PMC5544929 • DOI: 10.4049/jimmunol.1601477.

Artyomov, M.N., Munk, A., Gorvel, L., Korenfeld, D., Cella, M., Tung, T., Klechevsky, E. (2015) Modular expression analysis reveals functional conservation between human Langerhans Cells and mouse cross-priming dendritic cells. J Exp Med. May 4;212(5):743-57. PMCID PMC4419344 • DOI: 10.1084/jem.20131675.

Klechevsky, E. (2015) Functional diversity of human Dendritic Cells (Springer Adv Exp Med Biol. 2015;850:43-54.) DOI: 10.1007/978-3-319-15774-0_4.

Banchereau, J., Zurawski, S., Thompson-Snipes, L., Blanck, J.P., Clayton, S., Munk, A., Cao, Y., Wang, Z., Khandelwal, S., Hu, J., McCoy, W.H. 4th, Palucka, K.A., Reiter, Y., Fremont, D.H., Zurawski, G., Colonna, M., Shaw, A.S., Klechevsky, E. (2012) Immunoglobulin-like transcript receptors on human dermal CD14+ dendritic cells act as a CD8-antagonist to control cytotoxic T cell priming. Proc Natl Acad Sci USA. Nov 13;109(46):18885-90. PMCID PMC3503187 • DOI: 10.1073/pnas.1205785109.

Banchereau, J., Thompson-Snipes, L., Zurawski, S., Blanck, J.P., Cao, Y., Clayton, S., Gorvel, J.P., Zurawski, G., Klechevsky, E. (2012) The differential production of cytokines by human Langerhans Cells and dermal CD14+ DCs controls CTL priming. Blood. Jun; 14;119(24):5742-9. PMCID PMC3382933 • DOI: 10.1182/blood-2011-08-371245.

Klechevsky, E., Morita, R., Liu, M., Cao, Y., Coquery, S., Thompson-Snipes, L., Briere, F., Chaussabel, D., Zurawski, G., Palucka, A.K., Reiter, Y., Banchereau, J. and Ueno, H. (2008) Functional specializations of human epidermal Langerhans Cells and CD14+ dermal dendritic cells. Immunity. Sep; 29(3):497-510. PMCID2688399 DOI: 10.1016/j.immuni.2008.07.013.

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Assistant
Randi Lee
Office: 314.273.1733
Lee.r@wustl.edu